Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Molecular scissors and their application in genetically modified farm animals

(2015) Bjoern Petersen et al.   TRANSGENIC RESEARCH

Transgenic Expression of Human CD46 on Porcine Endothelium

(2015) Anjan K. Bongoni et al.   TRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Recent investigations into pig antigen and anti-pig antibody expression

(2015) Guerard W. Byrne et al.   International Journal of Surgery

Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing

(2014) Xiaoping Li et al.   CELL RESEARCH

Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus

(2014) Shun Li et al.   PLoS One

Successful Serial Recloning in the Mouse over Multiple Generations

(2013) Sayaka Wakayama et al.   Cell Stem Cell

Production of Multiple Transgenic Yucatan Miniature Pigs Expressing Human Complement Regulatory Factors, Human CD55, CD59, and H-Transferase Genes

(2013) Young-Hee Jeong et al.   PLoS One

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

(2013) Deug-Nam Kwon et al.   Scientific Reports

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Analyses of pig genomes provide insight into porcine demography and evolution

(2012) Martien A. M. Groenen et al.   NATURE

Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

(2012) Simon Leuchs et al.   PLoS One

Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs

(2012) Hye-Jung Yeom et al.   PLoS One

Expression of Human Thrombomodulin on the Endothelium of Pig Xenograft Donors

(2012) A. Wuensch et al.   TRANSPLANTATION

Human CD55 Expression Blocks Hyperacute Rejection and Restricts Complement Activation in Gal Knockout Cardiac Xenografts

(2012) Christopher G.A. McGregor et al.   TRANSPLANTATION

The effect of Gal expression on pig cells on the human T-cell xenoresponse

(2012) Tyler Wilhite et al.   XENOTRANSPLANTATION

Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β

(2011) Anita Ignatius et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear Transfer

(2011) Wei Deng et al.   PLoS One

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

(2011) J. Hauschild et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoregulation Effect by Overexpression of Heme Oxygenase-1 on Cardiac Xenotransplantation

(2011) Z. Shen et al.   TRANSPLANTATION PROCEEDINGS

Genetically-modified pig mesenchymal stromal cells: xenoantigenicity and effect on human T-cell xenoresponses

(2011) Mohamed Ezzelarab et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Combined Gene Therapy with Hypoxia-Inducible Factor-1α and Heme Oxygenase-1 for Therapeutic Angiogenesis

(2010) Suk Ho Bhang et al.   TISSUE ENGINEERING PART A

Structural characterization of α1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies

(2010) Mette Diswall et al.   XENOTRANSPLANTATION

Antibody-mediated xenograft injury: Mechanisms and protective strategies

(2009) Richard N. Pierson   TRANSPLANT IMMUNOLOGY

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Standard karyotype of the domestic pig

(2008) Ingemar Gustavsson   HEREDITAS

Development and Validation of a Highly Efficient Protocol of Porcine Somatic Cloning Using Preovulatory Embryo Transfer in Peripubertal Gilts

(2008) Björn Petersen et al.   Cloning Stem Cells