Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Gene Editing Technique in Xenotransplantation

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

(2017) Hanchao GAO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Xenotransplantation: Where do we stand in 2016?

(2017)   SWISS MEDICAL WEEKLY

CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing

(2017) Miguel A. Moreno-Mateos et al.   Nature Communications

Generation of complement protein C3 deficient pigs by CRISPR/Cas9-mediated gene targeting

(2017) Wei Zhang et al.   Scientific Reports

CRISPR: gene editing is just the beginning

(2016) Heidi Ledford   NATURE

A CRISPR Way to Block PERVs — Engineering Organs for Transplantation

(2016) Daniel R. Salomon   NEW ENGLAND JOURNAL OF MEDICINE

Silencing porcine genes significantly reduces human-anti-pig cytotoxicity profiles: an alternative to direct complement regulation

(2016) James R. Butler et al.   TRANSGENIC RESEARCH

Modified glycan models of pig-to-human xenotransplantation do not enhance the human-anti-pig T cell response

(2016) James R. Butler et al.   TRANSPLANT IMMUNOLOGY

Silencing the porcine iGb3s gene does not affect Galα3Gal levels or measures of anticipated pig-to-human and pig-to-primate acute rejection

(2016) James R. Butler et al.   XENOTRANSPLANTATION

Efficient production of biallelicGGTA1knockout pigsbycytoplasmic microinjection of CRISPR/Cas9 into zygotes

(2016) Bjoern Petersen et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

Construction of a CRISPR-Cas9 System for Pig Genome Targeting

(2015) Yu-Hsiu Su et al.   ANIMAL BIOTECHNOLOGY

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

Generation ofα-1,3-Galactosyltransferase-Deficient Porcine Embryonic Fibroblasts by CRISPR/Cas9-Mediated Knock-in of a Small Mutated Sequence and a Targeted Toxin-Based Selection System

(2015) M Sato et al.   REPRODUCTION IN DOMESTIC ANIMALS

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Current status of pig heart xenotransplantation

(2015) Muhammad M. Mohiuddin et al.   International Journal of Surgery

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins

(2014) S. Kim et al.   GENOME RESEARCH

Creating Class I MHC–Null Pigs Using Guide RNA and the Cas9 Endonuclease

(2014) Luz M. Reyes et al.   JOURNAL OF IMMUNOLOGY

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts

(2014) Masahiro Sato et al.   XENOTRANSPLANTATION

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

Discovery of the natural anti-Gal antibody and its past and future relevance to medicine

(2013) Uri Galili   XENOTRANSPLANTATION

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs

(2013) Deug-Nam Kwon et al.   Scientific Reports

Xenografted Islet Cell Clusters From INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

(2012) N. Klymiuk et al.   DIABETES

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Generation and Characterization of Human Heme Oxygenase-1 Transgenic Pigs

(2012) Hye-Jung Yeom et al.   PLoS One

Generation of Soluble Human Tumor Necrosis Factor-α Receptor 1-Fc Transgenic Pig

(2011) Bumrae Cho et al.   TRANSPLANTATION

Comparison of immunogenicity and porcine-to-rhesus lamellar corneal xenografts survival between fresh preserved and dehydrated porcine corneas

(2011) Aipeng Li et al.   XENOTRANSPLANTATION

Xenotransplantation-The Future of Corneal Transplantation?

(2010) Hidetaka Hara et al.   CORNEA

Complement activation and coagulation in xenotransplantation

(2009) Peter J Cowan et al.   IMMUNOLOGY AND CELL BIOLOGY

Genetic modification of pigs as organ donors for xenotransplantation

(2009) Nikolai Klymiuk et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?

(2009) A. Varki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Successful cross-breeding of cloned pigs expressing endo-β-galactosidase C and human decay accelerating factor

(2009) Satoko Yazaki et al.   XENOTRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION