Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons

(2015) S. Le Bas-Bernardet et al.   AMERICAN JOURNAL OF TRANSPLANTATION

FR104, an Antagonist Anti-CD28 Monovalent Fab' Antibody, Prevents Alloimmunization and Allows Calcineurin Inhibitor Minimization in Nonhuman Primate Renal Allograft

(2014) N. Poirier et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+T cell responses

(2014) Danya Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

(2014) Muhammad M. Mohiuddin et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

Effects of ASKP1240 Combined With Tacrolimus or Mycophenolate Mofetil on Renal Allograft Survival in Cynomolgus Monkeys

(2014) Lijun Song et al.   TRANSPLANTATION

Porcine Cytomegalovirus Infection Is Associated With Early Rejection of Kidney Grafts in a Pig to Baboon Xenotransplantation Model

(2014) Kazuhiko Yamada et al.   TRANSPLANTATION

Results of Life-Supporting Galactosyltransferase Knockout Kidneys in Cynomolgus Monkeys Using Two Different Sources of Galactosyltransferase Knockout Swine

(2014) Mitsuhiro Sekijima et al.   TRANSPLANTATION

Efficient generation of genetically distinct pigs in a single pregnancy using multiplexed single-guide RNA and carbohydrate selection

(2014) Ping Li et al.   XENOTRANSPLANTATION

Progress in pig-to-non-human primate transplantation models (1998-2013): a comprehensive review of the literature

(2014) David K. C. Cooper et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Immunological Challenges and Therapies in Xenotransplantation

(2014) M. Vadori et al.   Cold Spring Harbor Perspectives in Medicine

An Anti-CD154 Domain Antibody Prolongs Graft Survival and Induces Foxp3+iTreg in the Absence and Presence of CTLA-4 Ig

(2013) D. F. Pinelli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Kidney xenotransplantation

(2013) Peter J. Cowan et al.   KIDNEY INTERNATIONAL

Targeting co-stimulatory pathways: transplantation and autoimmunity

(2013) Mandy L. Ford et al.   Nature Reviews Nephrology

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Identification of human preformed antibody targets in GTKO pigs

(2012) Christopher Burlak et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

CD40-Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates

(2011) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pathologic Characteristics of Transplanted Kidney Xenografts

(2011) A. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons

(2011) S. Le Bas-Bernardet et al.   TRANSPLANTATION PROCEEDINGS

A Phase III Study of Belatacept-based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)

(2010) F. Vincenti et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Inducing CTLA-4-Dependent Immune Regulation by Selective CD28 Blockade Promotes Regulatory T Cells in Organ Transplantation

(2010) N. Poirier et al.   Science Translational Medicine

Identification of New Carbohydrate and Membrane Protein Antigens in Cardiac Xenotransplantation

(2010) Guerard W. Byrne et al.   TRANSPLANTATION

Belatacept and Basiliximab Diminish Human Antiporcine Xenoreactivity and Synergize to Inhibit Alloimmunity

(2009) Juliet A. Emamaullee et al.   TRANSPLANTATION

Proteomic identification of non-Gal antibody targets after pig-to-primate cardiac xenotransplantation

(2008) Guerard W. Byrne et al.   XENOTRANSPLANTATION