Evolution of sialic acids: Implications in xenotransplant biology

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Antibody glycoengineering strategies in mammalian cells

(2018) Qiong Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Malaria

(2018) Elizabeth A Ashley et al.   LANCET

Are the decrease in circulating anti-α1,3-Gal IgG and the lower content of galactosyl transferase A1 in the microbiota of patients with multiple sclerosis a novel environmental risk factor for the disease?

(2018) Emmanuel Montassier et al.   MOLECULAR IMMUNOLOGY

Fcγ Receptor Function and the Design of Vaccination Strategies

(2017) Stylianos Bournazos et al.   IMMUNITY

Are humans prone to autoimmunity? Implications from evolutionary changes in hominin sialic acid biology

(2017) Ajit Varki   JOURNAL OF AUTOIMMUNITY

Production of α1,3-galactosyltransferase and cytidine monophosphate-N-acetylneuraminic acid hydroxylase gene double-deficient pigs by CRISPR/Cas9 and handmade cloning

(2017) Hanchao GAO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Anti-Gal and Anti-Neu5Gc Responses in Nonimmunosuppressed Patients After Treatment With Rabbit Antithymocyte Polyclonal IgGs

(2017) Apolline Salama et al.   TRANSPLANTATION

The Immunoregulatory Roles of Antibody Glycosylation

(2017) Madeleine F. Jennewein et al.   TRENDS IN IMMUNOLOGY

The role of sialic acids in the immune recognition of xenografts

(2017) Beth M. French et al.   XENOTRANSPLANTATION

Glycan microarray reveal induced IgGs repertoire shift against a dietary carbohydrate in response to rabbit anti-human thymocyte therapy

(2017) Ron Amon et al.   Oncotarget

Evolution of host adaptation in the Salmonella typhoid toxin

(2017) Xiang Gao et al.   Nature Microbiology

Biological roles of glycans

(2016) Ajit Varki   GLYCOBIOLOGY

Human risk of diseases associated with red meat intake: Analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid

(2016) Frederico Alisson-Silva et al.   MOLECULAR ASPECTS OF MEDICINE

Human antibody recognition of xenogeneic antigens (NeuGc and Gal) on porcine heart valves: could genetically modified pig heart valves reduce structural valve deterioration?

(2016) Whayoung Lee et al.   XENOTRANSPLANTATION

Characterization of immunogenic Neu5Gc in bioprosthetic heart valves

(2016) Eliran Moshe Reuven et al.   XENOTRANSPLANTATION

Sialic acids in cancer biology and immunity

(2015) Oliver M T Pearce et al.   GLYCOBIOLOGY

Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation

(2015) Bruce S. Bochner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival

(2015) Grégoire Couvrat-Desvergnes et al.   JOURNAL OF CLINICAL INVESTIGATION

The immunological barriers to xenotransplantation

(2015) M. Vadori et al.   TISSUE ANTIGENS

Recent investigations into pig antigen and anti-pig antibody expression

(2015) Guerard W. Byrne et al.   International Journal of Surgery

Xenograft bioprosthetic heart valves: Past, present and future

(2015) Rizwan A. Manji et al.   International Journal of Surgery

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Glycans in immune recognition and response

(2014) Ron Amon et al.   CARBOHYDRATE RESEARCH

Host Adaptation of a Bacterial Toxin from the Human Pathogen Salmonella Typhi

(2014) Lingquan Deng et al.   CELL

Distribution of Non-Gal Antigens in Pig Cornea

(2014) David Cohen et al.   CORNEA

Diversity in structure and functions of antibody sialylation in the Fc

(2014) T Shantha Raju et al.   CURRENT OPINION IN BIOTECHNOLOGY

Changes in polysialic acid expression on myeloid cells during differentiation and recruitment to sites of inflammation: Role in phagocytosis

(2014) Nicholas M Stamatos et al.   GLYCOBIOLOGY

Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses

(2014) P. M. Drake et al.   JOURNAL OF IMMUNOLOGY

Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies

(2014) O. M. T. Pearce et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A red meat-derived glycan promotes inflammation and cancer progression

(2014) Annie N. Samraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation

(2014) Apolline Salama et al.   XENOTRANSPLANTATION

Erythrocytes from GGTA1/CMAH knockout pigs: implications for xenotransfusion and testing in non-human primates

(2014) Zheng-Yu Wang et al.   XENOTRANSPLANTATION

Hormesis in cancer immunology

(2014) Oliver MT Pearce et al.   OncoImmunology

Aiming at the sweet side of cancer: Aberrant glycosylation as possible target for personalized-medicine

(2013) Vered Padler-Karavani   CANCER LETTERS

Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates

(2013) Vered Padler-Karavani et al.   FASEB JOURNAL

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

Missing links in multiple sclerosis etiology. A working connecting hypothesis

(2013) Jean-Paul Soulillou   MEDICAL HYPOTHESES

Structure and function of the Salmonella Typhi chimaeric A2B5 typhoid toxin

(2013) Jeongmin Song et al.   NATURE

LC–MS Analysis of Polyclonal Human Anti-Neu5Gc Xeno-Autoantibodies Immunoglobulin G Subclass and Partial Sequence Using Multistep Intravenous Immunoglobulin Affinity Purification and Multienzymatic Digestion

(2012) Qiaozhen Lu et al.   ANALYTICAL CHEMISTRY

CD33-related siglecs as potential modulators of inflammatory responses

(2012) Paul R. Crocker et al.   Annals of the New York Academy of Sciences

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Red Meat Consumption and Mortality

(2012) Qi Sun   ARCHIVES OF INTERNAL MEDICINE

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Regulation of the metastatic cell phenotype by sialylated glycans

(2012) Matthew J. Schultz et al.   CANCER AND METASTASIS REVIEWS

Biomedical Differences Between Human and Nonhuman Hominids: Potential Roles for Uniquely Human Aspects of Sialic Acid Biology

(2011) Nissi M. Varki et al.   Annual Review of Pathology-Mechanisms of Disease

Human Xeno-Autoantibodies against a Non-Human Sialic Acid Serve as Novel Serum Biomarkers and Immunotherapeutics in Cancer

(2011) V. Padler-Karavani et al.   CANCER RESEARCH

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway

(2011) Robert M. Anthony et al.   NATURE

Induced Anti-Non Gal Antibodies in Human Xenograft Recipients

(2011) Uri Galili   TRANSPLANTATION

A plethora of Plasmodium species in wild apes: a source of human infection?

(2011) Julian C. Rayner et al.   TRENDS IN PARASITOLOGY

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Evolutionary Forces Shaping the Golgi Glycosylation Machinery: Why Cell Surface Glycans Are Universal to Living Cells

(2011) A. Varki   Cold Spring Harbor Perspectives in Biology

Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus

(2010) Renata Micha et al.   CIRCULATION

The Initial Immune Reaction to a New Tumor Antigen Is Always Stimulatory and Probably Necessary for the Tumor's Growth

(2010) Richmond T. Prehn   Clinical & Developmental Immunology

A Novel Role for the IgG Fc Glycan: The Anti-inflammatory Activity of Sialylated IgG Fcs

(2010) Robert M. Anthony et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

(2010) Darius Ghaderi et al.   NATURE BIOTECHNOLOGY

The Sialome—Far More Than the Sum of Its Parts

(2010) Miriam Cohen et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Polysialic acid and activity-dependent synapse remodeling

(2010) Luca Bonfanti et al.   Cell Adhesion & Migration

Basic and Clinical Immunology of Siglecs

(2009) Stephan von Gunten et al.   Annals of the New York Academy of Sciences

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

(2009) T. Pham et al.   BLOOD

Determination of glycosylation sites and site-specific heterogeneity in glycoproteins

(2009) Hyun Joo An et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Human-specific evolution of sialic acid targets: Explaining the malignant malaria mystery?

(2009) A. Varki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The origin of malignant malaria

(2009) S. M. Rich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

(2008) V. Padler-Karavani et al.   GLYCOBIOLOGY

Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression

(2008) M. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polysialic acid in the plasticity of the developing and adult vertebrate nervous system

(2007) Urs Rutishauser   NATURE REVIEWS NEUROSCIENCE