Genetically Modified Pigs as Organ Donors for Xenotransplantation

40 Days Survival after Orthotopic Cardiac Xenotransplantation of Multi-Transgenic Pig Hearts in a Pig-to-Baboon Model with CD40mAb or CD40L Costimulation Blockade and Xenograft Preservation using “Steens” Cold Blood Cardioplegia Perfusion

(2017) Paolo Brenner et al.   TRANSPLANTATION

Prolonged Survival of Pig Skin on Baboons After Administration of Pig Cells Expressing Human CD47

(2017) Aseda A. Tena et al.   TRANSPLANTATION

Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury

(2017) Christopher T. Laird et al.   XENOTRANSPLANTATION

The potentiating effect of hTFPI in the presence of hCD47 reduces the cytotoxicity of human macrophages

(2017) Sung Han Jung et al.   XENOTRANSPLANTATION

Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts

(2017) Hayato Iwase et al.   XENOTRANSPLANTATION

A Bridge to Somewhere

(2016) Jigesh A. Shah et al.   ANNALS OF SURGERY

Silencing Porcine CMAH and GGTA1 Genes Significantly Reduces Xenogeneic Consumption of Human Platelets by Porcine Livers

(2016) James Russell Butler et al.   TRANSPLANTATION

Efficient production of biallelicGGTA1knockout pigsbycytoplasmic microinjection of CRISPR/Cas9 into zygotes

(2016) Bjoern Petersen et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

(2015) H. E. Ahrens et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

(2015) Jose L. Estrada et al.   XENOTRANSPLANTATION

Current status of pig heart xenotransplantation

(2015) Muhammad M. Mohiuddin et al.   International Journal of Surgery

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system

(2014) Tang Hai et al.   CELL RESEARCH

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Thrombin Generation and Platelet Activation in a Xenogenic Lung Perfusion Model Determine Survival of GalTKO.hCD46 Lungs

(2013) L. Burdorf et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

The suppression of inflammatory macrophage-mediated cytotoxicity and proinflammatory cytokine production by transgenic expression of HLA-E

(2013) Akira Maeda et al.   TRANSPLANT IMMUNOLOGY

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

Regulation of human platelet aggregation by genetically modified pig endothelial cells and thrombin inhibition

(2013) Hayato Iwase et al.   XENOTRANSPLANTATION

Transgenic swine: Expression of human CD39 protects against myocardial injury

(2012) Debra G. Wheeler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The usefulness and limitations of the diabetic macaque model in evaluating long-term porcine islet xenograft survival

(2012) Melanie L. Graham et al.   XENOTRANSPLANTATION

B-Cell Depletion Extends the Survival of GTKO.hCD46Tg Pig Heart Xenografts in Baboons for up to 8 Months

(2011) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Therapeutic issues in the treatment of vascularized xenotransplants using gal-knockout donors in nonhuman primates

(2011) Burcin Ekser et al.   Current Opinion in Organ Transplantation

Coagulopathy in α-galactosyl transferase knockout pulmonary xenotransplants

(2011) Errol L. Bush et al.   XENOTRANSPLANTATION

Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation

(2011) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Potential value of human thrombomodulin and DAF expression for coagulation control in pig-to-human xenotransplantation

(2010) Yuko Miwa et al.   XENOTRANSPLANTATION

The vascular and coagulation issues in xenotransplantation

(2009) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs

(2009) Jagdeece Ramsoondar et al.   XENOTRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Heme Oxygenase-1 and the Vascular Bed: From Molecular Mechanisms to Therapeutic Opportunities

(2008) Agnieszka Loboda et al.   ANTIOXIDANTS & REDOX SIGNALING

Recombinant porcine endogenous retroviruses (PERV-A/C): a new risk for xenotransplantation?

(2008) Joachim Denner   ARCHIVES OF VIROLOGY