Progress in multiple genetically modified minipigs for xenotransplantation in China

Reducing immunoreactivity of porcine bioprosthetic heart valves by genetically-deleting three major glycan antigens, GGTA1/β4GalNT2/CMAH

(2018) Runjie Zhang et al.   Acta Biomaterialia

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

(2018) Fengjuan Liu et al.   MOLECULAR BIOTECHNOLOGY

B4GALNT2 and xenotransplantation: A newly appreciated xenogeneic antigen

(2018) Guerard Byrne et al.   XENOTRANSPLANTATION

Genetically Modified Pigs as Organ Donors for Xenotransplantation

(2017) Magdalena Hryhorowicz et al.   MOLECULAR BIOTECHNOLOGY

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9

(2017) Dong Niu et al.   SCIENCE

Cytokine profiles in Tibetan macaques following α-1,3-galactosyltransferase-knockout pig liver xenotransplantation

(2017) Zhuochao Zhang et al.   XENOTRANSPLANTATION

Initial study of α1,3-galactosyltransferase gene-knockout/CD46 pig full-thickness corneal xenografts in rhesus monkeys

(2017) Xiaojuan Dong et al.   XENOTRANSPLANTATION

Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9, editorial commentary

(2017) Linda Scobie et al.   XENOTRANSPLANTATION

PERV inactivation is necessary to guarantee absence of pig-to-patient PERVs transmission in xenotransplantation

(2017) Marc Güell et al.   XENOTRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

(2015) Hongchen Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

China to halt using executed prisoners’ organs for transplants: a step in the right direction in medical ethics

(2015) Yu-Tao Xiang et al.   JOURNAL OF MEDICAL ETHICS

Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

(2015) L. Yang et al.   SCIENCE

Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein

(2015) Agnes M. Azimzadeh et al.   XENOTRANSPLANTATION

Recent investigations into pig antigen and anti-pig antibody expression

(2015) Guerard W. Byrne et al.   International Journal of Surgery

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status

(2013) Hidetaka Hara et al.   IMMUNOLOGY

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs

(2013) Jige Xin et al.   PLoS One

Protective Effects of Transgenic Human Endothelial Protein C Receptor Expression in Murine Models of Transplantation

(2012) K. F. E. Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The sequence and analysis of a Chinese pig genome

(2012) Xiaodong Fang et al.   GigaScience

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Genetic modifications of pigs for medicine and agriculture

(2011) Jeffrey J. Whyte et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Antibody-mediated xenograft injury: Mechanisms and protective strategies

(2009) Richard N. Pierson   TRANSPLANT IMMUNOLOGY

Distribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation

(2009) Britta Dieckhoff et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

Current cellular immunological hurdles in pig-to-primate xenotransplantation

(2008) Stéphanie Le Bas-Bernardet et al.   TRANSPLANT IMMUNOLOGY

Coagulation dysregulation as a barrier to xenotransplantation in the primate

(2008) Chih Che Lin et al.   TRANSPLANT IMMUNOLOGY

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION