Contact system revisited: an interface between inflammation, coagulation, and innate immunity

Deficiency of plasminogen activator inhibitor 2 in plasma of patients with hereditary angioedema with normal C1 inhibitor levels

(2016) Kusumam Joseph et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation

(2015) Eva Göb et al.   ANNALS OF NEUROLOGY

The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis

(2015) K. F. Nickel et al.   BLOOD

Plasma contact system activation drives anaphylaxis in severe mast cell–mediated allergic reactions

(2015) Anna Sala-Cunill et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III

(2015) Jenny Björkqvist et al.   JOURNAL OF CLINICAL INVESTIGATION

Coagulation factor XII protease domain crystal structure

(2015) M. Pathak et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Polyphosphate accelerates factor V activation by factor XIa

(2015) Sharon Choi et al.   THROMBOSIS AND HAEMOSTASIS

Platelet Surface-Associated Activation and Secretion-Mediated Inhibition of Coagulation Factor XII

(2015) Natalia V. Zakharova et al.   PLoS One

Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis

(2014) R. J. Travers et al.   BLOOD

Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency

(2014) M. Zucker et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Single-chain factor XII exhibits activity when complexed to polyphosphate

(2014) R. Engel et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In vivo activation and functions of the protease factor XII

(2014) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

The role of coagulation/fibrinolysis during Streptococcus pyogenes infection

(2014) Torsten G. Loof et al.   Frontiers in Cellular and Infection Microbiology

Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels

(2013) S. Ghosh et al.   BLOOD

Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation

(2013) K. F. Nickel et al.   BLOOD

Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates

(2013) C. Puy et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Plasma kallikrein: the bradykinin-producing enzyme

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Hereditary angioedema: a bradykinin-mediated swelling disorder

(2013) Jenny Björkqvist et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial Cell Permeability during Hantavirus Infection Involves Factor XII-Dependent Increased Activation of the Kallikrein-Kinin System

(2013) Shannon L. Taylor et al.   PLoS Pathogens

In vivo roles of factor XII

(2012) T. Renne et al.   BLOOD

Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa

(2012) P. E. J. VAN DER MEIJDEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Coagulation factor activity and clinical bleeding severity in rare bleeding disorders: results from the European Network of Rare Bleeding Disorders

(2012) F. PEYVANDI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Polyphosphate binds to human von Willebrand factor in vivo and modulates its interaction with glycoprotein Ib

(2012) M. MONTILLA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nucleic acid scavengers inhibit thrombosis without increasing bleeding

(2012) S. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory mechanisms of the plasma contact system

(2012) Coen Maas et al.   THROMBOSIS RESEARCH

Crosstalk of the plasma contact system with bacteria

(2012) Katrin Faye Nickel et al.   THROMBOSIS RESEARCH

Factor XII gene missense mutation Thr328Lys in an Arab family with hereditary angioedema type III

(2011) M. L. Baeza et al.   ALLERGY

Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4

(2011) F. Semeraro et al.   BLOOD

Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding

(2011) A. S. Revenko et al.   BLOOD

Polyphosphate is a cofactor for the activation of factor XI by thrombin

(2011) S. H. Choi et al.   BLOOD

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

(2011) J. Konings et al.   BLOOD

Mast Cells Increase Vascular Permeability by Heparin-Initiated Bradykinin Formation In Vivo

(2011) Chris Oschatz et al.   IMMUNITY

Cleavage of Kininogen and Subsequent Bradykinin Release by the Complement Component: Mannose-Binding Lectin-Associated Serine Protease (MASP)-1

(2011) József Dobó et al.   PLoS One

The procoagulant and proinflammatory plasma contact system

(2011) Thomas Renné   Seminars in Immunopathology

The Plasma Contact System 2.0

(2011) Coen Maas et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Factor XII stimulates ERK1/2 and Akt through uPAR, integrins, and the EGFR to initiate angiogenesis

(2010) G. A. LaRusch et al.   BLOOD

Polyphosphate exerts differential effects on blood clotting, depending on polymer size

(2010) S. A. Smith et al.   BLOOD

Increased coagulation factor VIII, IX, XI and XII activities in non-alcoholic fatty liver disease

(2010) Anna Kotronen et al.   LIVER INTERNATIONAL

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wound healing in hemophilia B mice and low tissue factor mice

(2010) Dougald M. Monroe et al.   THROMBOSIS RESEARCH

Inorganic Polyphosphate: Essential for Growth and Survival

(2009) Narayana N. Rao et al.   Annual Review of Biochemistry

Dual role of collagen in factor XII-dependent thrombus formation

(2009) P. E. J. van der Meijden et al.   BLOOD

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

(2009) Felicitas Müller et al.   CELL

Catalytic Core of a Membrane-Associated Eukaryotic Polyphosphate Polymerase

(2009) M. Hothorn et al.   SCIENCE

Combined cis-regulator elements as important mechanism affecting FXII plasma levels

(2009) Maria Sabater-Lleal et al.   THROMBOSIS RESEARCH

Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin

(2008) Lan G. Coffman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Polyphosphate enhances fibrin clot structure

(2008) S. A. Smith et al.   BLOOD

Reduced thrombin generation increases host susceptibility to group A streptococcal infection

(2008) H. Sun et al.   BLOOD

Novel roles for factor XII-driven plasma contact activation system

(2008) Felicitas Müller et al.   CURRENT OPINION IN HEMATOLOGY

A complete factor XII deficiency does not affect coagulopathy, inflammatory responses, and lethality, but attenuates early hypotension in endotoxemic mice

(2008) T. IWAKI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS