The immunological barriers to xenotransplantation

Bortezomib, C1-Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi-Transgenic GalT-KO Pig Kidney Xenografts in Baboons

(2015) S. Le Bas-Bernardet et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Dual Islet Transplantation Modeling of the Instant Blood-Mediated Inflammatory Reaction

(2015) B. M. Martin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-Term Control of Diabetes in Immunosuppressed Nonhuman Primates (NHP) by the Transplantation of Adult Porcine Islets

(2015) J. S. Shin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Expression of NeuGc on pig heart valves

(2015) Whayoung Lee et al.   XENOTRANSPLANTATION

Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

(2015) Hayato Iwase et al.   XENOTRANSPLANTATION

Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model

(2015) Laura Higginbotham et al.   XENOTRANSPLANTATION

Current achievements and future perspectives in whole-organ bioengineering

(2015) Andrea Peloso et al.   Stem Cell Research & Therapy

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

(2014) A. Tena et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Altered Glycosylation in Donor Mice Causes Rejection of Strain-Matched Skin and Heart Grafts

(2014) H. Gock et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs

(2014) C. Burlak et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Desensitization for solid organ and hematopoietic stem cell transplantation

(2014) Andrea A. Zachary et al.   IMMUNOLOGICAL REVIEWS

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

Defunctioning Polymorphism in the Immunoglobulin G Inhibitory Receptor (FcγRIIB-T/T232) Does not Impact on Kidney Transplant or Recipient Survival

(2014) Menna R. Clatworthy et al.   TRANSPLANTATION

Identification of HLA-A2-restricted immunogenic peptides derived from a xenogenic porcine major histocompatibility complex

(2014) Chan-Su Park et al.   XENOTRANSPLANTATION

Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve grafts

(2014) Angela Barone et al.   XENOTRANSPLANTATION

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen

(2014) Guerard W. Byrne et al.   XENOTRANSPLANTATION

One-Year Heterotopic Cardiac Xenograft Survival in a Pig to Baboon Model

(2013) M. M. Mohiuddin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Lack of CD47 on Donor Hepatocytes Promotes Innate Immune Cell Activation and Graft Loss: A Potential Barrier to Hepatocyte Xenotransplantation

(2013) Nalu Navarro-Alvarez et al.   CELL TRANSPLANTATION

A comparison of the main structures of N-glycans of porcine islets with those from humans

(2013) Shuji Miyagawa et al.   GLYCOBIOLOGY

Identification of the Tetraspanin CD82 as a New Barrier to Xenotransplantation

(2013) S. M. Saleh et al.   JOURNAL OF IMMUNOLOGY

Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts

(2013) L. Scobie et al.   JOURNAL OF IMMUNOLOGY

A lectin microarray study of glycoantigens in neonatal porcine islet-like cell clusters

(2013) Akira Maeda et al.   JOURNAL OF SURGICAL RESEARCH

Fibronectin from alpha 1,3-galactosyltransferase knockout pigs is a xenoantigen

(2013) Ray K. Chihara et al.   JOURNAL OF SURGICAL RESEARCH

Characterisation of the Xenogeneic Immune Response to Microencapsulated Fetal Pig Islet-Like Cell Clusters Transplanted into Immunocompetent C57BL/6 Mice

(2013) Vijayaganapathy Vaithilingam et al.   PLoS One

Expression of Recipient CD47 on Rat Insulinoma Cell Xenografts Prevents Macrophage-Mediated Rejection through SIRPα Inhibitory Signaling in Mice

(2013) Yoshifumi Teraoka et al.   PLoS One

ITIM-dependent negative signaling pathways for the control of cell-mediated xenogeneic immune responses

(2013) Maria-Luisa del Rio et al.   XENOTRANSPLANTATION

Minimal effect of bortezomib in reducing anti-pig antibodies in human leukocyte antigen-sensitized patients: a pilot study

(2013) Hidetaka Hara et al.   XENOTRANSPLANTATION

Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation

(2013) Andrew J. Lutz et al.   XENOTRANSPLANTATION

N-linked glycan profiling of GGTA1/CMAH knockout pigs identifies new potential carbohydrate xenoantigens

(2013) Christopher Burlak et al.   XENOTRANSPLANTATION

B-cell depletion in SLE: clinical and trial experience with rituximab and ocrelizumab and implications for study design

(2013) Venkat Reddy et al.   ARTHRITIS RESEARCH & THERAPY

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis

(2012) T. Kuriyama et al.   BLOOD

Early Islet Damage after Direct Exposure of Pig Islets to Blood: Has Humoral Immunity Been Underestimated?

(2012) Dirk J. Van Der Windt et al.   CELL TRANSPLANTATION

Ectopic expression of murine CD47 minimizes macrophage rejection of human hepatocyte xenografts in immunodeficient mice

(2012) Johan M. Waern et al.   HEPATOLOGY

Multiple Receptors Trigger Human NK Cell-Mediated Cytotoxicity against Porcine Chondrocytes

(2012) R. Sommaggio et al.   JOURNAL OF IMMUNOLOGY

Diagnostic challenges in chronic antibody-mediated rejection

(2012) Evan A. Farkash et al.   Nature Reviews Nephrology

Identification of human preformed antibody targets in GTKO pigs

(2012) Christopher Burlak et al.   XENOTRANSPLANTATION

The effect of Gal expression on pig cells on the human T-cell xenoresponse

(2012) Tyler Wilhite et al.   XENOTRANSPLANTATION

Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs

(2012) Gisella L. Puga Yung et al.   XENOTRANSPLANTATION

Rationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity

(2012) Henrik E Mei et al.   ARTHRITIS RESEARCH & THERAPY

Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials

(2011) Bryan N. Brown et al.   Acta Biomaterialia

Islet Xenotransplantation Using Gal-Deficient Neonatal Donors Improves Engraftment and Function

(2011) P. Thompson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Pathologic Characteristics of Transplanted Kidney Xenografts

(2011) A. Shimizu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation

(2011) Guerard W. Byrne et al.   XENOTRANSPLANTATION

First quantitative assay of alpha-Gal in soft tissues: Presence and distribution of the epitope before and after cell removal from xenogeneic heart valves

(2010) F. Naso et al.   Acta Biomaterialia

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD47 Is Required for Suppression of Allograft Rejection by Donor-Specific Transfusion

(2010) H. Wang et al.   JOURNAL OF IMMUNOLOGY

Human Leukocyte Transmigration Across Galα(1,3)Gal-Negative Porcine Endothelium Is Regulated by Human CD18 and CD99

(2010) Mårten K. J. Schneider et al.   TRANSPLANTATION

Determination of the precursor frequency and the reaction intensity of xenoreactive human T lymphocytes

(2010) Hiroyuki Tahara et al.   XENOTRANSPLANTATION

Structural characterization of α1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies

(2010) Mette Diswall et al.   XENOTRANSPLANTATION

Investigation of potential carbohydrate antigen targets for human and baboon antibodies

(2010) Peter Yeh et al.   XENOTRANSPLANTATION

Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies

(2010) Nabin B. Basnet et al.   XENOTRANSPLANTATION

Results of Gal-Knockout Porcine Thymokidney Xenografts

(2009) A. D. Griesemer et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Long-Term Controlled Normoglycemia in Diabetic Non-Human Primates After Transplantation with hCD46 Transgenic Porcine Islets

(2009) D. J. van der Windt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cell Sheet-Based Myocardial Tissue Engineering: New Hope for Damaged Heart Rescue

(2009) Tatsuya Shimizu et al.   CURRENT PHARMACEUTICAL DESIGN

Qualitative and quantitative comparison ofN-glycans between pig endothelial and islet cells by high-performance liquid chromatography and mass spectrometry-based strategy

(2009) Yun-Gon Kim et al.   JOURNAL OF MASS SPECTROMETRY

Human monoclonal HLA antibodies reveal interspecies crossreactive swine MHC class I epitopes relevant for xenotransplantation

(2009) Arend Mulder et al.   MOLECULAR IMMUNOLOGY

A Porcine-Derived Acellular Dermal Scaffold That Supports Soft Tissue Regeneration: Removal of Terminal Galactose-α-(1,3)-Galactose and Retention of Matrix Structure

(2009) Hui Xu et al.   TISSUE ENGINEERING PART A

Pig-to-nonhuman primate islet xenotransplantation

(2009) Bernhard J. Hering et al.   TRANSPLANT IMMUNOLOGY

The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients

(2009) Mohamed Ezzelarab et al.   TRANSPLANTATION

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Anticarbohydrate Antibody Repertoires in Patients Transplanted with Fetal Pig Islets Revealed by Glycan Arrays

(2008) O. Blixt et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IgG deposition and activation of the classical complement pathway involvement in the activation of human granulocytes by decellularized porcine heart valve tissue

(2008) Fabienne Bastian et al.   BIOMATERIALS

Dissecting the instant blood-mediated inflammatory reaction in islet xenotransplantation

(2008) Masafumi Goto et al.   XENOTRANSPLANTATION

Identification of an anti-idiotypic antibody that defines a B-cell subset(s) producing xenoantibodies in primates

(2007) Jacqueline Fischer-Lougheed et al.   IMMUNOLOGY