Osteocyte-Mediated Translation of Mechanical Stimuli to Cellular Signaling and Its Role in Bone and Non-bone-Related Clinical Complications

Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation

(2019) Vikte Lionikaite et al.   FASEB JOURNAL

Pro-inflammatory Cytokines and Osteocytes

(2019) Miao Zhou et al.   Current Osteoporosis Reports

Mechanical regulation of bone formation and resorption around implants in a mouse model of osteopenic bone

(2019) Zihui Li et al.   Journal of the Royal Society Interface

miR-29b-3p regulated osteoblast differentiation via regulating IGF-1 secretion of mechanically stimulated osteocytes

(2019) Qiangcheng Zeng et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Exercise Alleviates Osteoporosis in Rats with Mild Chronic Kidney Disease by Decreasing Sclerostin Production

(2019) Hung-Wei Liao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sclerostin and WNT‐5a gingival protein levels in chronic periodontitis and health

(2019) Georgios S. Chatzopoulos et al.   JOURNAL OF PERIODONTAL RESEARCH

Osteocytes and mechanical loading: The Wnt connection

(2019) Whitney A. Bullock et al.   Orthodontics & Craniofacial Research

Bone and heart health in chronic kidney disease

(2019) Aline Martin   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Connexin43 enhances Wnt and PGE2-dependent activation of β-catenin in osteoblasts

(2019) Aditi Gupta et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Integrins in Osteocyte Biology and Mechanotransduction

(2019) Ivor P. Geoghegan et al.   Current Osteoporosis Reports

The osteocyte: A multifunctional cell within the bone

(2019) F.G.F. Tresguerres et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

The biogenesis, biology and characterization of circular RNAs

(2019) Lasse S. Kristensen et al.   NATURE REVIEWS GENETICS

Recombinant sclerostin antagonizes effects of ex vivo mechanical loading in trabecular bone and increases osteocyte lacunar size

(2018) M. Kogawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

OUP accepted manuscript

(2018)   BIOINFORMATICS

Prednisolone treatment reduces the osteogenic effects of loading in mice

(2018) I. Bergström et al.   BONE

Primary cilia proteins: ciliary and extraciliary sites and functions

(2018) Kiet Hua et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling

(2018) Yu-Heng V. Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Skeletal changes during and after spaceflight

(2018) Laurence Vico et al.   Nature Reviews Rheumatology

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

(2018) Steve Stegen et al.   Nature Communications

β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

(2018) Yukiko Kitase et al.   Cell Reports

Mechanically induced autophagy is associated with ATP metabolism and cellular viability in osteocytes in vitro

(2018) Bingbing Zhang et al.   Redox Biology

Mechanically-Loaded Breast Cancer Cells Modify Osteocyte Mechanosensitivity by Secreting Factors That Increase Osteocyte Dendrite Formation and Downstream Resorption

(2018) Wenbo Wang et al.   Frontiers in Endocrinology

Mechanically stimulated osteocytes reduce the bone-metastatic potential of breast cancer cells in vitro by signaling through endothelial cells

(2018) Yu-Heng Vivian Ma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pulsed electromagnetic fields regulate osteocyte apoptosis, RANKL/OPG expression, and its control of osteoclastogenesis depending on the presence of primary cilia

(2018) Pan Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies

(2018) Sonia Vallet et al.   Pharmaceutics

Supraphysiological loading induces osteocyte-mediated osteoclastogenesis in a novel in vitro model for bone implant loosening

(2017) Anna Fahlgren et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway

(2017) Xi Chen et al.   Molecular Medicine Reports

Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

(2017) Karl J. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Osteocytes regulate osteoblast differentiation and osteoclast activity through Interleukin-6 under mechanical loading

(2017) Zhichao Hao et al.   RSC Advances

Aging, Osteocytes, and Mechanotransduction

(2017) Haniyeh Hemmatian et al.   Current Osteoporosis Reports

Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease

(2017) Michelle M. McDonald et al.   Current Osteoporosis Reports

Effect of Osteocyte-Ablation on Inorganic Phosphate Metabolism: Analysis of Bone–Kidney–Gut Axis

(2017) Osamu Fujii et al.   Frontiers in Endocrinology

The impact of microgravity on bone in humans

(2016) Daniela Grimm et al.   BONE

Low intensity vibration mitigates tumor progression and protects bone quantity and quality in a murine model of myeloma

(2016) Gabriel M. Pagnotti et al.   BONE

T-Type voltage-sensitive calcium channels mediate mechanically-induced intracellular calcium oscillations in osteocytes by regulating endoplasmic reticulum calcium dynamics

(2016) Genevieve N. Brown et al.   BONE

Systemic Inflammation Affects Human Osteocyte-Specific Protein and Cytokine Expression

(2016) Janak L. Pathak et al.   CALCIFIED TISSUE INTERNATIONAL

Role of vinculin in cellular mechanotransduction

(2016) Wolfgang H. Goldmann   CELL BIOLOGY INTERNATIONAL

Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism

(2016) Julia C. Chen et al.   FASEB JOURNAL

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

(2016) Jesus Delgado-Calle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading

(2016) Marta Maycas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of Wnt Signaling by Mechanical Loading Is Impaired in the Bone of Old Mice

(2016) Nilsson Holguin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanical Stress Regulates Bone Metabolism Through MicroRNAs

(2016) Yu Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteoblast-derived VEGF regulates osteoblast differentiation and bone formation during bone repair

(2016) Kai Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

PTH signaling mediates perilacunar remodeling during exercise

(2016) Joseph D. Gardinier et al.   MATRIX BIOLOGY

Primary cilia are not calcium-responsive mechanosensors

(2016) M. Delling et al.   NATURE

The Role of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblast Response to Microgravity: Mechanistic Implications for Osteoporosis Development

(2016) Anne Camirand et al.   PLoS One

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

(2016) Zeynep Seref-Ferlengez et al.   PLoS One

Dynamic fluid flow induced mechanobiological modulation of in situ osteocyte calcium oscillations

(2015) Minyi Hu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction

(2015) Jia-Ning Zhang et al.   BONE

In vivo mechanical loading rapidly activates β-catenin signaling in osteocytes through a prostaglandin mediated mechanism

(2015) N. Lara-Castillo et al.   BONE

Bone's responses to mechanical loading are impaired in type 1 diabetes

(2015) Ashutosh Parajuli et al.   BONE

Mechanical Loading Reduces Inflammation-Induced Human Osteocyte-to-Osteoclast Communication

(2015) Janak L. Pathak et al.   CALCIFIED TISSUE INTERNATIONAL

Fine-tuned ATP signals are acute mediators in osteocyte mechanotransduction

(2015) Tina M. Kringelbach et al.   CELLULAR SIGNALLING

The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytesin Vitro

(2015) Jordan M. Spatz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage

(2015) Chao Liu et al.   JOURNAL OF BIOMECHANICS

MiR-494-3p induced by compressive force inhibits cell proliferation in MC3T3-E1 cells

(2015) Yuki Iwawaki et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

microRNA-103a Functions as a Mechanosensitive microRNA to Inhibit Bone Formation Through Targeting Runx2

(2015) Bin Zuo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of the Parathyroid Hormone Type 1 Receptor (PTH1R) as a Mechanosensor in Osteocyte Survival

(2015) Marta Maycas et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Differential sclerostin and parathyroid hormone response to exercise in boys and men

(2015) B. Falk et al.   OSTEOPOROSIS INTERNATIONAL

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CIRI: an efficient and unbiased algorithm for de novo circular RNA identification

(2015) Yuan Gao et al.   GENOME BIOLOGY

Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

(2014) Xue Yuan et al.   Annals of the New York Academy of Sciences

Integrin αv in the mechanical response of osteoblast lineage cells

(2014) Keiko Kaneko et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nascent Adhesions: From Fluctuations to a Hierarchical Organization

(2014) Zhiqi Sun et al.   CURRENT BIOLOGY

Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

(2014) Alyson Morse et al.   JOURNAL OF BONE AND MINERAL RESEARCH

VEGF Receptor 2 (VEGFR2) Activation Is Essential for Osteocyte Survival Induced by Mechanotransduction

(2014) Luis F. de Castro et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IL-6 Alters Osteocyte Signaling toward Osteoblasts but Not Osteoclasts

(2014) A.D. Bakker et al.   JOURNAL OF DENTAL RESEARCH

Inflammatory factors in the circulation of patients with active rheumatoid arthritis stimulate osteoclastogenesis via endogenous cytokine production by osteoblasts

(2014) J. L. Pathak et al.   OSTEOPOROSIS INTERNATIONAL

Biomechanical Aspects of the Muscle-Bone Interaction

(2014) Keith G. Avin et al.   Current Osteoporosis Reports

Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity

(2013) K.-H. William Lau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inactivation of Lrp5 in osteocytes reduces Young's modulus and responsiveness to the mechanical loading

(2013) Liming Zhao et al.   BONE

Nitric Oxide is Involved in the Down-regulation of SOST Expression Induced by Mechanical Loading

(2013) Jesús Delgado-Calle et al.   CALCIFIED TISSUE INTERNATIONAL

Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway

(2013) Zhaohong Wang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading

(2013) Da Jing et al.   FASEB JOURNAL

Primary cilia respond to fluid shear stress and mediate flow-induced calcium deposition in osteoblasts

(2013) Robin M. Delaine-Smith et al.   FASEB JOURNAL

Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH

(2013) Vaibhav Saini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

(2013) Shoichi Kaneshiro et al.   JOURNAL OF BONE AND MINERAL METABOLISM

In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model

(2013) Maureen E Lynch et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice

(2013) Nicoletta Bivi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mechanosensory responses of osteocytes to physiological forces occur along processes and not cell body and require  V 3 integrin

(2013) M. M. Thi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading

(2012) Takuo Kubota et al.   ACTA ASTRONAUTICA

Mechanical loading prevents the stimulating effect of IL-1β on osteocyte-modulated osteoclastogenesis

(2012) Rishikesh N. Kulkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

(2012) Jessica Kopf et al.   BMC BIOLOGY

Calcium response in osteocytic networks under steady and oscillatory fluid flow

(2012) X. Lucas Lu et al.   BONE

Osteocyte control of osteoclastogenesis

(2012) Charles A. O'Brien et al.   BONE

Osteocyte RANKL: New insights into the control of bone remodeling

(2012) Jinhu Xiong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

(2012) Jordan M Spatz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

Is interaction between age-dependent decline in mechanical stimulation and osteocyte–estrogen receptor levels the culprit for postmenopausal-impaired bone formation?

(2012) R. Sapir-Koren et al.   OSTEOPOROSIS INTERNATIONAL

Mechanosensing by the Primary Cilium: Deletion of Kif3A Reduces Bone Formation Due to Loading

(2012) Sara Temiyasathit et al.   PLoS One

Mechanical Load Modulates the Stimulatory Effect of BMP2 in a Rat Nonunion Model

(2012) Carolin Schwarz et al.   TISSUE ENGINEERING PART A

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

(2011) Chandrasekhar Kesavan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MT1-MMP modulates the mechanosensitivity of osteocytes

(2011) Rishikesh N. Kulkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

(2011) Leanne K. Saxon et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Mechanical Loading Stimulates BMP7, But Not BMP2, Production by Osteocytes

(2011) Ana Santos et al.   CALCIFIED TISSUE INTERNATIONAL

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

(2011) Zhousheng Xiao et al.   FASEB JOURNAL

Hypoxia-inducible Factor-1α Protein Negatively Regulates Load-induced Bone Formation

(2011) Ryan C. Riddle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow

(2011) X Lucas Lu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

(2010) Mohamed A. Kamel et al.   BONE

Mechanical Loading-Related Bone Gain Is Enhanced by Tamoxifen but Unaffected by Fulvestrant in Female Mice

(2010) Toshihiro Sugiyama et al.   ENDOCRINOLOGY

PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling

(2010) Yumie Rhee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

(2010) S. Burra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanosomes Carry a Loaded Message

(2010) J. P. Bidwell et al.   Science Signaling

Attachment of Osteocyte Cell Processes to the Bone Matrix

(2009) L.M. McNamara et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Tumor necrosis factor α and interleukin-1β modulate calcium and nitric oxide signaling in mechanically stimulated osteocytes

(2009) A. D. Bakker et al.   ARTHRITIS AND RHEUMATISM

Early activation of the β-catenin pathway in osteocytes is mediated by nitric oxide, phosphatidyl inositol-3 kinase/Akt, and focal adhesion kinase

(2009) Ana Santos et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effect of dual frequency cyclic compression on matrix deposition by osteoblast-like cells grown in 3D scaffolds and on modulation of VEGF variant expression

(2009) Virginie Dumas et al.   BIOMATERIALS

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Conditional Disruption ofPkd1in Osteoblasts Results in Osteopenia Due to Direct Impairment of Bone Formation

(2009) Zhousheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteocyte calcium signaling response to bone matrix deformation

(2009) Taiji Adachi et al.   JOURNAL OF BIOMECHANICS

Secondary Hyperparathyroidism: Pathophysiology and Treatment

(2009) W. Saliba et al.   Journal of the American Board of Family Medicine

Focal Adhesion Kinase Is Important for Fluid Shear Stress–Induced Mechanotransduction in Osteoblasts

(2008) Suzanne RL Young et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone morphogenetic proteins in tissue engineering: the road from the laboratory to the clinic, part I (basic concepts)

(2008) P. C. Bessa et al.   Journal of Tissue Engineering and Regenerative Medicine

Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts

(2008) C. Sanchez et al.   OSTEOARTHRITIS AND CARTILAGE

Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading

(2007) Lidan You et al.   BONE

The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects

(2006) Joseph E. Zerwekh et al.   JOURNAL OF BONE AND MINERAL RESEARCH