IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

Akt1 regulates phosphorylation and osteogenic activity of Dlx3

(2012) You Hee Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling

(2012) Barbara Peruzzi et al.   Nature Communications

Selective Signaling by Akt1 Controls Osteoblast Differentiation and Osteoblast-Mediated Osteoclast Development

(2011) A. Mukherjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis

(2010) Benoit Le Goff et al.   JOINT BONE SPINE

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

(2010) Shigeru Kotake et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role of mitogen-activated protein kinase in osteoblast differentiation

(2010) Fu-Hsiung Lin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Bone vascularization and trabecular bone formation are mediated by PKBalpha/Akt1 in a gene-dosage-dependent manner: In vivo and ex vivo MRI

(2010) Katrien Vandoorne et al.   MAGNETIC RESONANCE IN MEDICINE

Rapid and sustained improvement in bone and cartilage turnover markers with the anti–interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: Results from a substudy of the multicenter double-blind, placebo-controlled trial of tocilizumab in inadequate responders to methotrexate alone

(2009) Patrick Garnero et al.   ARTHRITIS AND RHEUMATISM

Selective Signaling by Akt2 Promotes Bone Morphogenetic Protein 2-Mediated Osteoblast Differentiation

(2009) A. Mukherjee et al.   MOLECULAR AND CELLULAR BIOLOGY

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

(2009) T. Matsushita et al.   MOLECULAR AND CELLULAR BIOLOGY

Interleukin-6 Inhibits Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclastogenesis by Diverting Cells into the Macrophage Lineage: Key Role of Serine727Phosphorylation of Signal Transducer and Activator of Transcription 3

(2008) Laurence Duplomb et al.   ENDOCRINOLOGY

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA