Mechanical Load Increases in Bone Formation via a Sclerostin-Independent Pathway

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Paradoxical Sost gene expression response to mechanical unloading in metaphyseal bone

(2013) Brandon R. Macias et al.   BONE

Serum Dickkopf 1 Levels in Sclerostin Deficiency

(2013) A. H. van Lierop et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

(2012) Jordan M Spatz et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Sclerostin Increases in Healthy Adult Men during Bed Rest

(2012) J. M. Spatz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Conditional disruption of IGF-I gene in type 1α collagen-expressing cells shows an essential role of IGF-I in skeletal anabolic response to loading

(2011) Chandrasekhar Kesavan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

(2011) Asiri R. Wijenayaka et al.   PLoS One

Role of Endocrine and Paracrine Factors in the Adaptation of Bone to Mechanical Loading

(2011) Joanna S. Price et al.   Current Osteoporosis Reports

Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells

(2010) Astrid Liedert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancellous bone adaptation to tibial compression is not sex dependent in growing mice

(2010) Maureen E. Lynch et al.   JOURNAL OF APPLIED PHYSIOLOGY

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

(2010) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss

(2010) Agostino Gaudio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor α and disuse

(2009) Gul Zaman et al.   BONE

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice

(2009) Ina Kramer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin in Mineralized Matrices and van Buchem Disease

(2009) R.L. van Bezooijen et al.   JOURNAL OF DENTAL RESEARCH

Localization ofSOST/sclerostin in cementocytesin vivoand in mineralizing periodontal ligament cellsin vitro

(2009) A. Jäger et al.   JOURNAL OF PERIODONTAL RESEARCH

The high bone mass phenotype of Sost deficient mice is characterized by progressive increase in bone thickness, mineralization and predicted cortical bone strength in a gene dosage unrelated manner

(2008) Ina Kramer et al.   BONE

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Mass Is Preserved and Cancellous Architecture Altered Due to Cyclic Loading of the Mouse Tibia After Orchidectomy

(2008) J Christopher Fritton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH