Article
Biology
Sen Zhao, Zebin Chen, Taiyang Li, Qing Sun, Huijie Leng, Bo Huo
Summary: This study investigated the characteristics of fluid flow at different scales in cancellous bone in rat femurs, as well as the effects of osteoporosis and loading frequency. The results showed that the wall fluid shear stress (FSS) around osteocytes exhibited a linear relationship with loading frequency and was smaller in the osteoporotic group. This study provides important insights into bone remodeling under cyclic loading and the development of strategies for osteoporosis treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Robert T. Brady, Fergal J. O'Brien, David A. Hoey
Summary: Bone is a dynamic organ that can adapt its structure through the release of soluble factors by osteocytes. The study investigated the role of composition and dimensionality in directing Sost expression in MLO-Y4 cells and found that culture in hydroxyapatite-containing collagen scaffolds enhanced Sost expression compared to traditional in vitro culture. The study also showed that the novel culture system responded to fluid flow stimulation. Overall, this study presents a novel culture system for the MLO-Y4 osteocyte cell line and provides valuable insights into Sost expression in bone cells.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Anushree Dwivedi, Patrick A. Kiely, David A. Hoey
Summary: Bone is a common site for breast cancer metastasis, with mechanically stimulated osteocytes releasing factors that enhance cancer cell proliferation and migration. The secretome of mechanically activated osteocytes contains specific cytokines that potentially drive breast cancer metastasis to bone.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Alice L. Bouchard, Chrisanne Dsouza, Catherine Julien, Maximilian Rummler, Marie-Helene Gaumond, Nicolas Cermakian, Bettina M. Willie
Summary: The study shows that the adaptive response of bone to mechanical loading is regulated by circadian rhythms, with circadian clocks controlling the expression of specific genes in bone tissue, impacting bone morphology and function.
Article
Engineering, Biomedical
Xi Chen, Yasuko Moriyama, Yoko Takemura, Maho Rokuta, Yasunori Ayukawa
Summary: This study aimed to evaluate the influence of estrogen deficiency and mechanical loading on bone around osseointegrated dental implants in a rat jaw model. The results showed that estrogen deficiency could affect the long-term stability of implants, while mechanical loading could attenuate the negative effects of estrogen deficiency on bone formation and osseointegration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie
Summary: This study found that mechanical loading can enhance bone mass, prevent osteolytic destruction, and inhibit the growth and dissemination of multiple myeloma cells in mice. These findings suggest that physical stimuli may serve as an anabolic treatment for osteolytic bone destruction in patients with multiple myeloma.
ACTA BIOMATERIALIA
(2021)
Article
Biology
Dezhi Zhao, Manuel A. Riquelme, Teja Guda, Chao Tu, Huiyun Xu, Sumin Gu, Jean X. Jiang
Summary: This study demonstrates the critical role of osteocytic Cx43 hemichannels in the anabolic function of bone in response to mechanical loading. Inhibition of hemichannels impeded the response of osteoblast activity and bone formation to mechanical loading, suggesting that targeting osteocytic Cx43 hemichannels could be a potential therapeutic strategy for bone loss and osteoporosis.
Article
Endocrinology & Metabolism
Xiaohan Lai, Rebecca Chung, Yihan Li, Xiaowei Sherry Liu, Liyun Wang
Summary: The study used a multiscale poroelastic modeling technique to investigate the effects of lactation on the physicochemical environment and mechanosensing of osteocytes in murine tibiae. The results showed that lactation-induced LCS expansion and PCM reduction promoted solute transport and osteocyte mechanosensing, while higher loading frequency and sparser PCM enhanced flow-mediated mechanosensing and nutrient transport.
Article
Medicine, General & Internal
Daniel Brian Shropshire, Francisca M. Acosta, Kun Fang, Jaime Benavides, Lu-Zhe Sun, Victor X. Jin, Jean X. Jiang
Summary: This study uncovered a correlation between ATP paracrine signaling genes and bone metastasis in ER+ breast and prostate cancers, with higher levels of ENTPD1, NT5E, and ADORA3 in bone metastasis tissues. The study also demonstrated the potential therapeutic targets for cancer bone metastasis through extracellular ATP degradation and adenosine receptor signaling.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Bai Zhang, Xueyi Li, Kai Tang, Ying Xin, Guanshuo Hu, Yufan Zheng, Keming Li, Cunyu Zhang, Youhua Tan
Summary: Tumor cells with the ability to adhere to specific organ endothelium exhibit enhanced metastatic tropism to that target organ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chengyu Yang, Yang Liu, Ziyan Wang, Minmin Lin, Chao Liu
Summary: Controlled anabolic mechanical loading enhances bone formation mainly through Type H vessels in a S1Pr1-dependent manner.
Article
Engineering, Biomedical
Jianhua Zhang, Julia Griesbach, Marsel Ganeyev, Anna-Katharina Zehnder, Peng Zeng, Gian Nutal Schaedli, Anke de Leeuw, Yuxiao Lai, Marina Rubert, Ralph Mueller
Summary: The study reveals that mechanical stimulation can promote the formation of 3D bioprinted bone organoids, and long-term mechanical loading is necessary for increasing the density and stiffness of the organoids, as well as promoting osteoblast differentiation.
Article
Biochemistry & Molecular Biology
Lisa Y. Lawson, Nicole Migotsky, Christopher J. Chermside-Scabbo, John T. Shuster, Kyu Sang Joeng, Roberto Civitelli, Brendan Lee, Matthew J. Silva
Summary: Mechanical loading stimulates bone formation, and the Wnt signaling pathway plays a crucial role in the skeletal response to loading. Specifically, Wnt1 mediates the mechano-adaptive response to loading.
Article
Cell Biology
Menglu Huang, Hong Liu, Lei Zhu, Xinle Li, Jie Li, Shuang Yang, Daquan Liu, Xiaomeng Song, Hiroki Yokota, Ping Zhang
Summary: This study demonstrates that mechanical loading significantly protects tumor-invaded bone by regulating the fate of bone marrow-derived cells, alleviating breast cancer-associated bone metastasis. In obese mice, mechanical loading reduces obesity-associated bone degradation, suppresses osteoclastogenesis, and promotes osteogenesis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Stefaan W. Verbruggen, Anuphan Sittichokechaiwut, Gwendolen C. Reilly
Summary: The purpose of this review is to provide an overview of osteocytes and the primary cilium, discussing their role in osteocyte mechanosensing. Recent findings suggest that osteocytes are the primary mechanosensing cells in bone tissue, with the primary cilium serving as a key mechanosensing mechanism. However, more research is needed to understand the specific molecular mechanisms governed by the primary cilium in osteocytes.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Cell & Tissue Engineering
Maureen E. Lynch, Aaron E. Chiou, Min Joon Lee, Stephen C. Marcott, Praveen V. Polamraju, Yeonkyung Lee, Claudia Fischbach
TISSUE ENGINEERING PART A
(2016)
Article
Biotechnology & Applied Microbiology
L. E. Barney, L. E. Jansen, S. R. Polio, S. Galarza, M. E. Lynch, S. R. Peyton
CURRENT OPINION IN CHEMICAL ENGINEERING
(2016)
Article
Multidisciplinary Sciences
Frank He, Aaron E. Chiou, Hyun Chae Loh, Maureen Lynch, Bo Ri Seo, Young Hye Song, Min Joon Lee, Rebecca Hoerth, Emely L. Bortel, Bettina M. Willie, Georg N. Duda, Lara A. Estroff, Admir Masic, Wolfgang Wagermaier, Peter Fratzl, Claudia Fischbach
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biotechnology & Applied Microbiology
Boyuan Liu, Suyue Han, Brandon P. Hedrick, Yahya Modarres-Sadeghi, Maureen E. Lynch
BIOTECHNOLOGY AND BIOENGINEERING
(2018)
Review
Pharmacology & Pharmacy
Maureen E. Lynch, Claudia Fischbach
ADVANCED DRUG DELIVERY REVIEWS
(2014)
Review
Engineering, Biomedical
David W. Infanger, Maureen E. Lynch, Claudia Fischbach
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 15
(2013)
Article
Endocrinology & Metabolism
Maureen E. Lynch, Russell P. Main, Qian Xu, Thomas L. Schmicker, Mitchell B. Schaffler, Timothy M. Wright, Marjolein C. H. van der Meulen
Article
Physiology
Maureen E. Lynch, Russell P. Main, Qian Xu, Daniel J. Walsh, Mitchell B. Schaffler, Timothy M. Wright, Marjolein C. H. van der Meulen
JOURNAL OF APPLIED PHYSIOLOGY
(2010)
Article
Biophysics
Russell P. Main, Maureen E. Lynch, Marjolein C. H. van der Meulen
JOURNAL OF BIOMECHANICS
(2010)
Article
Endocrinology & Metabolism
Maureen E. Lynch, Daniel Brooks, Sunish Mohanan, Min Joon Lee, Praveen Polamraju, Kelsey Dent, Lawrence J. Bonassar, Marjolein C. H. van der Meulen, Claudia Fischbach
JOURNAL OF BONE AND MINERAL RESEARCH
(2013)
Article
Biology
Russell P. Main, Maureen E. Lynch, Marjolein C. H. van der Meulen
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Engineering, Biomedical
Maximilian Rummler, Fani Ziouti, Alice L. Bouchard, Andreas Brandl, Georg N. Duda, Bjarne Bogen, Andreas Beilhack, Maureen E. Lynch, Franziska Jundt, Bettina M. Willie
Summary: This study found that mechanical loading can enhance bone mass, prevent osteolytic destruction, and inhibit the growth and dissemination of multiple myeloma cells in mice. These findings suggest that physical stimuli may serve as an anabolic treatment for osteolytic bone destruction in patients with multiple myeloma.
ACTA BIOMATERIALIA
(2021)
Article
Robotics
Teresa A. Kent, Suhan Kim, Gabriel Kornilowicz, Wenzhen Yuan, Mitra J. Z. Hartmann, Sarah Bergbreiter
Summary: The development of whisker-based sensing systems faces challenges in scaling the number of whiskers while maintaining a simple interface, and in detecting various stimuli that biological whiskers can sense. The design presented here uses a camera to measure whisker rotations, with whiskers magnetically attached to an elastomer skin for scalability and reconfigurability. Direct contact and airflow can be measured by the relative motion between each whisker and the skin, with an algorithm developed to distinguish inertial forces from airflow and contact.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2021)