Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton

Primary Cilium Regulates CaV1.2 Expression Through Wnt Signaling

(2014) Brian S. Muntean et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes

(2014) C.L. Thompson et al.   OSTEOARTHRITIS AND CARTILAGE

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury

(2013) Shixuan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cell cycle progression by the repression of primary cilia formation in proliferating cells

(2013) Hidemasa Goto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways

(2013) Changdong Wang et al.   EXPERIMENTAL CELL RESEARCH

Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo

(2013) Kristen L. Lee et al.   FASEB JOURNAL

Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage

(2013) Jerome Irianto et al.   JOURNAL OF BIOMECHANICS

Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia

(2013) Steven Su et al.   NATURE METHODS

The ciliary flow sensor and polycystic kidney disease

(2013) Fruzsina Kotsis et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Surface topography regulates wnt signaling through control of primary cilia structure in mesenchymal stem cells

(2013) R. J. McMurray et al.   Scientific Reports

Mechanically induced osteogenic lineage commitment of stem cells

(2013) Julia C Chen et al.   Stem Cell Research & Therapy

A review of hedgehog signaling in cranial bone development

(2013) Angel Pan et al.   Frontiers in Physiology

TRPV4-associated skeletal dysplasias

(2012) Gen Nishimura et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Kinesin motors and primary cilia

(2012) Kristen J. Verhey et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The intraflagellar transport protein IFT80 is required for cilia formation and osteogenesis

(2012) Shuying Yang et al.   BONE

Mechanosensation and transduction in osteocytes

(2012) Jenneke Klein-Nulend et al.   BONE

Emerging role of primary cilia as mechanosensors in osteocytes

(2012) An M. Nguyen et al.   BONE

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

(2012) Junmin Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Primary cilia elongation in response to interleukin-1 mediates the inflammatory response

(2012) A. K. T. Wann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The extracellular matrix and ciliary signaling

(2012) Tamina Seeger-Nukpezah et al.   CURRENT OPINION IN CELL BIOLOGY

The ciliary pocket

(2012) Alexandre Benmerah   CURRENT OPINION IN CELL BIOLOGY

Cilia in vertebrate development and disease

(2012) E. C. Oh et al.   DEVELOPMENT

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

(2012) Karolin V. Dorn et al.   DEVELOPMENTAL CELL

Bardet–Biedl syndrome

(2012) Elizabeth Forsythe et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes

(2012) Angus K. T. Wann et al.   FASEB JOURNAL

The ciliary Evc/Evc2 complex interacts with Smo and controls Hedgehog pathway activity in chondrocytes by regulating Sufu/Gli3 dissociation and Gli3 trafficking in primary cilia

(2012) Jose A. Caparrós-Martín et al.   HUMAN MOLECULAR GENETICS

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes

(2012) Qihong Zhang et al.   HUMAN MOLECULAR GENETICS

Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia

(2012) N. Qiu et al.   JOURNAL OF CELL SCIENCE

NEK1andDYNC2H1are both involved in short rib polydactyly Majewski type but not in Beemer Langer cases

(2012) Joyce El Hokayem et al.   JOURNAL OF MEDICAL GENETICS

Ift88 regulates Hedgehog signaling,Sfrp5expression, and β-catenin activity in post-natal growth plate

(2012) Ching-Fang Chang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Primary cilia act as mechanosensors during bone healing around an implant

(2012) P. Leucht et al.   MEDICAL ENGINEERING & PHYSICS

Centrosome Fine Ultrastructure of the Osteocyte Mechanosensitive Primary Cilium

(2012) R.E. Uzbekov et al.   MICROSCOPY AND MICROANALYSIS

The BBSome controls IFT assembly and turnaround in cilia

(2012) Qing Wei et al.   NATURE CELL BIOLOGY

The role of primary cilia in the pathophysiology of neural tube defects

(2012) Timothy W. Vogel et al.   Neurosurgical Focus

Chondrocyte primary cilia shorten in response to osmotic challenge and are sites for endocytosis

(2012) D.R. Rich et al.   OSTEOARTHRITIS AND CARTILAGE

Mechanosensing by the Primary Cilium: Deletion of Kif3A Reduces Bone Formation Due to Loading

(2012) Sara Temiyasathit et al.   PLoS One

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Primary cilium-dependent sensing of urinary flow and paracrine purinergic signaling

(2012) Helle A. Praetorius et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Wnt Signaling in Bone Development and Disease: Making Stronger Bone with Wnts

(2012) J. B. Regard et al.   Cold Spring Harbor Perspectives in Biology

Orientation of Primary Cilia of Articular Chondrocytes in Three-Dimensional Space

(2011) Cornelia E. Farnum et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells

(2011) David A. Hoey et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base

(2011) María Pacheco et al.   BONE

Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

(2011) Stefano Zanotti et al.   CALCIFIED TISSUE INTERNATIONAL

Primary cilia and organogenesis: is Hedgehog the only sculptor?

(2011) Evangelia Tasouri et al.   CELL AND TISSUE RESEARCH

Architecture and function of IFT complex proteins in ciliogenesis

(2011) Michael Taschner et al.   DIFFERENTIATION

Conditional deletion of Pkd1 in osteocytes disrupts skeletal mechanosensing in mice

(2011) Zhousheng Xiao et al.   FASEB JOURNAL

Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia

(2011) J. B. Wallingford et al.   GENES & DEVELOPMENT

The emerging face of primary cilia

(2011) Norann A. Zaghloul et al.   GENESIS

An Ift80 mouse model of short rib polydactyly syndromes shows defects in hedgehog signalling without loss or malformation of cilia

(2011) Suzanne Rix et al.   HUMAN MOLECULAR GENETICS

The mechanics of the primary cilium: An intricate structure with complex function

(2011) David A. Hoey et al.   JOURNAL OF BIOMECHANICS

Downregulation of PKD1 by shRNA results in defective osteogenic differentiation via cAMP/PKA pathway in human MG-63 cells

(2011) Ni Qiu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TMJ Development and Growth Require Primary Cilia Function

(2011) T. Kinumatsu et al.   JOURNAL OF DENTAL RESEARCH

PDGF in bone formation and regeneration: New insights into a novel mechanism involving MSCs

(2011) Arnold I. Caplan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter

(2011) Carlos E de Andrea et al.   JOURNAL OF PATHOLOGY

Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization

(2011) Maria-Grazia Ascenzi et al.   JOURNAL OF THEORETICAL BIOLOGY

Soluble levels of cytosolic tubulin regulate ciliary length control

(2011) Neeraj Sharma et al.   MOLECULAR BIOLOGY OF THE CELL

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

(2011) Madeline A. Lancaster et al.   NATURE CELL BIOLOGY

Ciliogenesis: building the cell's antenna

(2011) Hiroaki Ishikawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis

(2011) C.-F. Chang et al.   OSTEOARTHRITIS AND CARTILAGE

Intraflagellar transport: a new player at the immune synapse

(2011) Francesca Finetti et al.   TRENDS IN IMMUNOLOGY

Bone Development: Overview of Bone Cells and Signaling

(2011) Anna Teti   Current Osteoporosis Reports

Role of the polycytin-primary cilia complex in bone development and mechanosensing

(2010) Z.S. Xiao et al.   Annals of the New York Academy of Sciences

Osteocyte primary cilium and its role in bone mechanotransduction

(2010) Sara Temiyasathit et al.   Annals of the New York Academy of Sciences

Mesenchymal Stem Cells as Therapeutics

(2010) Biju Parekkadan et al.   Annual Review of Biomedical Engineering

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

Mechanisms for osteogenic differentiation of human mesenchymal stem cells induced by fluid shear stress

(2010) Liyue Liu et al.   Biomechanics and Modeling in Mechanobiology

The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells

(2010) Daniel J. Kelly et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Mechanical loading modulates chondrocyte primary cilia incidence and length

(2010) Susan R McGlashan et al.   CELL BIOLOGY INTERNATIONAL

The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment

(2010) Padmaja Tummala et al.   Cellular and Molecular Bioengineering

Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells

(2010) Ronald Y. Kwon et al.   FASEB JOURNAL

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

The primary cilium at a glance

(2010) P. Satir et al.   JOURNAL OF CELL SCIENCE

The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia

(2010) A. Molla-Herman et al.   JOURNAL OF CELL SCIENCE

Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma

(2010) Carlos E de Andrea et al.   LABORATORY INVESTIGATION

Functional genomic screen for modulators of ciliogenesis and cilium length

(2010) Joon Kim et al.   NATURE

Kif3a Deficiency Reverses the Skeletal Abnormalities in Pkd1 Deficient Mice by Restoring the Balance Between Osteogenesis and Adipogenesis

(2010) Ni Qiu et al.   PLoS One

Ciliary Abnormalities Due to Defects in the Retrograde Transport Protein DYNC2H1 in Short-Rib Polydactyly Syndrome

(2009) Amy E. Merrill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DYNC2H1 Mutations Cause Asphyxiating Thoracic Dystrophy and Short Rib-Polydactyly Syndrome, Type III

(2009) Nathalie Dagoneau et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ellis-van Creveld syndrome and Weyers acrodental dysostosis are caused by cilia-mediated diminished response to hedgehog ligands

(2009) Victor L. Ruiz-Perez et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Polycystins and Primary Cilia: Primers for Cell Cycle Progression

(2009) Jing Zhou   Annual Review of Physiology

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

SnapShot: Intraflagellar Transport

(2009) Douglas G. Cole et al.   CELL

The Pyrophosphate Transporter ANKH is Expressed in Kidney and Bone Cells and Colocalises to the Primary Cilium/Basal Body Complex

(2009) Georgina Carr et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Intraflagellar transport: it's not just for cilia anymore

(2009) Cosima T Baldari et al.   CURRENT OPINION IN CELL BIOLOGY

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

Conditional Disruption ofPkd1in Osteoblasts Results in Osteopenia Due to Direct Impairment of Bone Formation

(2009) Zhousheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of the Primary Cilium Component Polaris in Synchondrosis Development

(2009) T. Ochiai et al.   JOURNAL OF DENTAL RESEARCH

Mutation in IFT80 in a fetus with the phenotype of Verma-Naumoff provides molecular evidence for Jeune-Verma-Naumoff dysplasia spectrum

(2009) D. P. Cavalcanti et al.   JOURNAL OF MEDICAL GENETICS

Cartilage abnormalities associated with defects of chondrocytic primary cilia in Bardet-Biedl syndrome mutant mice

(2009) Anjan P. Kaushik et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

(2009) Francesca Finetti et al.   NATURE CELL BIOLOGY

Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease

(2009) Iben R. Veland et al.   NEPHRON PHYSIOLOGY

Primary Cilia Are Not Required for Normal Canonical Wnt Signaling in the Mouse Embryo

(2009) Polloneal Jymmiel R. Ocbina et al.   PLoS One

Generation of mice with a conditional allele for Ift172

(2009) Paul W. Howard et al.   TRANSGENIC RESEARCH

Mechanotransduction in osteoblast regulation and bone disease

(2009) Katerina K. Papachroni et al.   TRENDS IN MOLECULAR MEDICINE

The Emerging Role of Wnt/PCP Signaling in Organ Formation

(2009) Rodney M. Dale et al.   Zebrafish

The Primary Cilium of Connective Tissue Cells: Imaging by Multiphoton Microscopy

(2008) Eve Donnelly et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Primary cilia in osteoarthritic chondrocytes: From chondrons to clusters

(2008) S.R. McGlashan et al.   DEVELOPMENTAL DYNAMICS

Polycystin-1 Regulates Skeletogenesis through Stimulation of the Osteoblast-specific Transcription FactorRUNX2-II

(2008) Zhousheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osmolarity Influences Chondrocyte Death in Wounded Articular Cartilage

(2008) Anish K Amin et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Wnt and Hedgehog Signaling Pathways in Bone Development

(2008) Timothy F. Day et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

PDGF Receptor β Is a Potent Regulator of Mesenchymal Stromal Cell Function

(2008) Ayano Tokunaga et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Intraflagellar transport motors in cilia: moving along the cell's antenna

(2008) Jonathan M. Scholey   JOURNAL OF CELL BIOLOGY

Regulation of chondrogenesis and chondrocyte differentiation by stress

(2008) Michael J. Zuscik et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanotransduction in Human Bone

(2008) Alexander Scott et al.   SPORTS MEDICINE