Article
Physics, Fluids & Plasmas
Misha Perepelitsa, Ilya Timofeyev, Patrick Murphy, Oleg A. Igoshin
Summary: This study develops a model to describe the alignment behavior of self-propelled rods, and derives the evolution equation for the kinetic density function using a set of microscopic-level rules. The results show that the alignment based on purely physical collisions is less robust.
Article
Biochemistry & Molecular Biology
Kevin Michael Creamer, Heather Jill Kolpa, Jeanne Bentley Lawrence
Summary: The study finds that most RNA in nuclear chromatin is repeat-rich, non-coding, and derived predominantly from introns of nascent transcripts, which co-distributes with scaffold proteins and affects chromatin compaction. This indicates that long nascent transcripts play a dynamic structural role in promoting the open architecture of active chromosome territories.
Article
Biology
Sangyoon J. Han, Evgenia Azarova, Austin J. Whitewood, Alexia Bachir, Edgar Guttierrez, Alex Groisman, Alan R. Horwitz, Benjamin T. Goult, Kevin M. Dean, Gaudenz Danuser
Summary: The study reveals the crucial role of concurrent recruitment of talin and vinculin in early integrin-based nascent adhesions, which is essential for the maturation of NAs. Specifically, the function of the R8 domain in talin is identified as important for NA maturation, affecting vinculin binding and recruitment rates.
Article
Chemistry, Multidisciplinary
Katherine C. Elbert, Thi Vo, Deborah Oh, Harshit Bharti, Sharon C. Glotzer, Christopher B. Murray
Summary: Self-assembly is a popular approach to control the formation of complex, multicomponent materials. By designing specific structures and leveraging solvent evaporation dynamics, nanocrystals can be organized into ordered structures.
Article
Cell Biology
Caroline S. Cencer, Jennifer B. Silverman, Leslie M. Meenderink, Evan S. Krystofiak, Bryan A. Millis, Matthew J. Tyska
Summary: This study reveals that during epithelial cell differentiation, nascent microvilli are stabilized at the cell margins through the formation of transjunctional intermicrovillar adhesion complexes (IMACs). This finding provides insights into the assembly of apical specializations in various epithelial systems.
DEVELOPMENTAL CELL
(2023)
Article
Physics, Multidisciplinary
Kuang Liu, Alison E. Patteson, Edward J. Banigan, J. M. Schwarz
Summary: This study shows that the dynamics of chromosomes and nuclear shape in the cell nucleus come from motor activity, with a model of an active, cross-linked Rouse chain identifying the physical mechanisms. System-sized motions require both motor activity and cross-links, with contractile motors enhancing chromosome dynamics. Nuclear shape fluctuations are dependent on factors such as motor strength, cross-linking, and chromosome-lamina binding.
PHYSICAL REVIEW LETTERS
(2021)
Article
Cell Biology
Laura Hakanpaa, Amr Abouelezz, An-Sofie Lenaerts, Seyda Culfa, Michael Algie, Jenny Barlund, Pekka Katajisto, Harvey McMahon, Leonardo Almeida-Souza
Summary: Hakanpaa et al. discovered that reticular adhesions are formed at flat clathrin lattices, a process inhibited by fibronectin and its receptor integrin alpha 5 beta 1. This novel adhesion assembly mechanism is involved in cell migration and reveals a unique crosstalk between cell-matrix adhesions.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Physical
Timothee Vignaud, Calina Copos, Christophe Leterrier, Mauricio Toro-Nahuelpan, Qingzong Tseng, Julia Mahamid, Laurent Blanchoin, Alex Mogilner, Manuel Thery, Laetitia Kurzawa
Summary: This study reveals the mechanical impact of interconnected actomyosin bundles on the production and distribution of traction forces within cells. Experimental and modeling results show that these bundles are embedded in a continuous and contractile network, and the propagation of their contraction throughout the cell is dependent on this embedding. The mechanism of stress fibre assembly through the coalescence of actin filaments in the cell cortex enables the transmission of mechanical forces throughout the entire cell.
Article
Business
Xiaohui Shi, Feng Li, Pattarin Chumnumpan
Summary: This study explores the emergence and development of innovation platforms in nascent industries, using the example of the U.K.'s TRTG industry. Four key capabilities – innovation leverage, market exploration, quality control, and appropriation – are identified as crucial for successful platform development. The article also discusses how firms can redefine their boundaries to deploy these capabilities effectively.
JOURNAL OF MANAGEMENT
(2021)
Article
Multidisciplinary Sciences
Sangram Kadam, Kiran Kumari, Vinoth Manivannan, Shuvadip Dutta, Mithun K. K. Mitra, Ranjith Padinhateeri
Summary: The authors provide a quantitative description of chromatin as bead-spring polymers, predicting the 3D size of chromatin beads and quantifying their stretchability, bendability, and softness. They systematically coarse-grain chromatin using Micro-C data and derive essential quantities for polymer representation. They also challenge the prevailing notion by showing that chromatin beads must be considered soft particles that can overlap, and in doing so, they derive an effective inter-bead soft potential and quantify an overlap parameter. Additionally, they analyze bond lengths and bond angles to gain insights into chromatin folding and local bendability.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Andrew D. Doyle, Daniel J. Sykora, Gustavo G. Pacheco, Matthew L. Kutys, Kenneth M. Yamada
Summary: The study reveals that fibroblasts and mesenchymal cancer cells utilize a cellular contractile mechanism to migrate in 3D collagen gels, with varying 3D migration cycles between cell types. It is essential for efficient directional cell migration to maintain prestrain and anterior contractions, which require myosin IIA. Epithelial cancer and endothelial cells show little sustained prestrain or anterior contractions, suggesting a different mechanism for migration.
DEVELOPMENTAL CELL
(2021)
Article
Multidisciplinary Sciences
Peng Zhang, Wenzhang Dou, Huaping Liu
Summary: This paper proposes two hierarchical data structures for flowchart design, which significantly reduce storage space, improve traversal efficiency, and resolve the problem of nesting between sub-charts compared to traditional graph data structures.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Timo Krueger, Ivan Maryshev, Erwin Frey
Summary: Topological defects play a central role in the formation and organization of various biological systems. In this paper, agent-based simulations are used to study phase-separated active nematics and the formation of -1/2 defects. The authors investigate the morphology and characteristics of these defects, as well as observe and characterize lateral arc-like structures separating from nematic bands. The study also introduces a hydrodynamic theory that explains the emergence of defects and arcs.
Article
Cell Biology
Isabel N. Goronzy, Sofia A. Quinodoz, Joanna W. Jachowicz, Noah Ollikainen, Prashant Bhat, Mitchell Guttman
Summary: Mammalian genomes are organized into A/B compartments, and transcription occurs within B compartments with multiple active genes colocalizing. Genes proximal to nucleoli can also undergo transcription. This study provides important insights into the relationship between genome structure and transcription.
Review
Nanoscience & Nanotechnology
Rui Zhang, Ali Mozaffari, Juan J. de Pablo
Summary: Active liquid crystals, with their inherent structural anisotropy, exhibit long-range order and topological defects. This Review discusses both natural and synthetic active liquid crystals, exploring their autonomous behavior as well as potential applications.
NATURE REVIEWS MATERIALS
(2021)
Review
Cell Biology
Zhiqi Sun, Shengzhen S. Guo, Reinhard Fassler
JOURNAL OF CELL BIOLOGY
(2016)
Article
Cell Biology
Zhiqi Sun, Hui-Yuan Tseng, Steven Tan, Fabrice Senger, Laetitia Kurzawa, Dirk Dedden, Naoko Mizuno, Anita A. Wasik, Manuel Thery, Alexander R. Dunn, Reinhard Faessler
NATURE CELL BIOLOGY
(2016)
Review
Cell Biology
Nan-Peng Chen, Zhiqi Sun, Reinhard Faessler
CURRENT OPINION IN CELL BIOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Jingyi Gong, Zhiqi Sun, Peng Li
CURRENT OPINION IN LIPIDOLOGY
(2009)
Article
Cell Biology
Zhiqi Sun, Reinhard Faessler
GENES & DEVELOPMENT
(2012)
Article
Biochemistry & Molecular Biology
Zongqian Nian, Zhiqi Sun, Luxin Yu, Shen Yon Toh, Jianli Sang, Peng Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Cell Biology
Jingyi Gong, Zhiqi Sun, Lizhen Wu, Wenyi Xu, Nicole Schieber, Dijin Xu, Guanghou Shui, Hongyuan Yang, Robert G. Parton, Peng Li
JOURNAL OF CELL BIOLOGY
(2011)
Article
Cell Biology
Herbert B. Schiller, Michaela-Rosemarie Hermann, Julien Polleux, Timothee Vignaud, Sara Zanivan, Caroline C. Friedel, Zhiqi Sun, Aurelia Raducanu, Kay-E. Gottschalk, Manuel Thery, Matthias Mann, Reinhard Faessler
NATURE CELL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Zhiqi Sun, Jingyi Gong, Han Wu, Wenyi Xu, Lizhen Wu, Dijin Xu, Jinlan Gao, Jai-wei Wu, Hongyuan Yang, Maojun Yang, Peng Li
NATURE COMMUNICATIONS
(2013)
Article
Cell Biology
Zhiqi Sun, Mercedes Costell, Reinhard Faessler
NATURE CELL BIOLOGY
(2019)
Article
Chemistry, Physical
Patrizia M. Spoerri, Nico Strohmeyer, Zhiqi Sun, Reinhard Faessler, Daniel J. Mueller
