Comparative Pro-cognitive and Neurochemical Profiles of Glycine Modulatory Site Agonists and Glycine Reuptake Inhibitors in the Rat: Potential Relevance to Cognitive Dysfunction and Its Management

The GlyT1 Inhibitor Bitopertin Ameliorates Allodynia and Hyperalgesia in Animal Models of Neuropathic and Inflammatory Pain

(2018) Anja Armbruster et al.   Frontiers in Molecular Neuroscience

Potential and Challenges for the Clinical Use of d-Serine As a Cognitive Enhancer

(2018) Gerson D. Guercio et al.   Frontiers in Psychiatry

The Discrimination Ratio derived from Novel Object Recognition tasks as a Measure of Recognition Memory Sensitivity, not Bias

(2018) Magali H. Sivakumaran et al.   Scientific Reports

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory

(2017) M Amin Khan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

D-Cycloserine Ameliorates Autism-Like Deficits by Removing GluA2-Containing AMPA Receptors in a Valproic Acid-Induced Rat Model

(2017) Han-Fang Wu et al.   MOLECULAR NEUROBIOLOGY

Ketamine and its metabolite (2R,6R)-hydroxynorketamine induce lasting alterations in glutamatergic synaptic plasticity in the mesolimbic circuit

(2017) N Yao et al.   MOLECULAR PSYCHIATRY

Ketamine enhances structural plasticity in mouse mesencephalic and human iPSC-derived dopaminergic neurons via AMPAR-driven BDNF and mTOR signaling

(2017) L Cavalleri et al.   MOLECULAR PSYCHIATRY

Involvement of neuronal and glial activities in control of the extracellular d -serine concentrations by the AMPA glutamate receptor in the mouse medial prefrontal cortex

(2017) Sayuri Ishiwata et al.   NEUROCHEMISTRY INTERNATIONAL

Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex

(2017) D.M. Bortz et al.   NEUROPHARMACOLOGY

Negative Symptom Interventions in Youth at Risk of Psychosis: A Systematic Review and Network Meta-analysis

(2017) Daniel J Devoe et al.   SCHIZOPHRENIA BULLETIN

Blood levels of D-amino acid oxidase vs. D-amino acids in reflecting cognitive aging

(2017) Chieh-Hsin Lin et al.   Scientific Reports

Sodium Benzoate, a D-Amino Acid Oxidase Inhibitor, Added to Clozapine for the Treatment of Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial

(2017) Chieh-Hsin Lin et al.   BIOLOGICAL PSYCHIATRY

D-cycloserine improves synaptic transmission in an animal mode of Rett syndrome

(2017) Elisa S. Na et al.   PLoS One

The involvement ofN-methyl-d-aspartate receptor (NMDAR) subunit NR1 in the pathophysiology of schizophrenia

(2016) Peijun Ju et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

GLYX-13 (rapastinel) ameliorates subchronic phencyclidine- and ketamine-induced declarative memory deficits in mice

(2016) Lakshmi Rajagopal et al.   BEHAVIOURAL BRAIN RESEARCH

Enhancement of Psychosocial Treatment With D-Cycloserine: Models, Moderators, and Future Directions

(2016) Michael W. Otto et al.   BIOLOGICAL PSYCHIATRY

Asc-1 Transporter Regulation of Synaptic Activity via the Tonic Release of d-Serine in the Forebrain

(2016) Hagit Sason et al.   CEREBRAL CORTEX

D-cycloserine in Schizophrenia: New Strategies for Improving Clinical Outcomes by Enhancing Plasticity

(2016) Donald Goff   Current Neuropharmacology

The dopamine D 3 -preferring D 2 /D 3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia

(2016) David J.G. Watson et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia

(2016) Philip LR Gaskin et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

True alignment of preclinical and clinical research to enhance success in CNS drug development: a review of the current evidence

(2016) Pascal JD Goetghebeur et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders

(2016) Mark J Millan et al.   JOURNAL OF PSYCHOPHARMACOLOGY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Altering the course of schizophrenia: progress and perspectives

(2016) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers

(2016) Carsten Hofmann et al.   PSYCHOPHARMACOLOGY

The NMDA receptor ‘glycine modulatory site’ in schizophrenia: d-serine, glycine, and beyond

(2015) Darrick T Balu et al.   CURRENT OPINION IN PHARMACOLOGY

Inhibition of glycine transporter 1: The yellow brick road to new schizophrenia therapy?

(2015) Philipp Singer et al.   CURRENT PHARMACEUTICAL DESIGN

Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex

(2015) Dominik Strzelecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of glutamate positive modulators on cognitive deficits in schizophrenia: a systematic review and meta-analysis of double-blind randomized controlled trials

(2015) Y Iwata et al.   MOLECULAR PSYCHIATRY

GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders

(2015) Jared W Young et al.   NEUROPSYCHOPHARMACOLOGY

Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia

(2015) Shigeyuki Chaki et al.   PSYCHOPHARMACOLOGY

Adjunctive sarcosine plus benzoate improved cognitive function in chronic schizophrenia patients with constant clinical symptoms: A randomised, double-blind, placebo-controlled trial

(2015) Chun-Yuan Lin et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

d-serine levels in Alzheimer’s disease: implications for novel biomarker development

(2015) C Madeira et al.   Translational Psychiatry

A Trial of D-Cycloserine to Treat Stereotypies in Older Adolescents and Young Adults With Autism Spectrum Disorder

(2014) Maria Urbano et al.   CLINICAL NEUROPHARMACOLOGY

The Novel Object Recognition Test in Rodents in Relation to Cognitive Impairment in Schizophrenia

(2014) Lakshmi Rajagopal et al.   CURRENT PHARMACEUTICAL DESIGN

Astroglial d-serine is the endogenous co-agonist at the presynaptic NMDA receptor in rat entorhinal cortex

(2014) Alex M. Lench et al.   NEUROPHARMACOLOGY

Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat

(2014) Philip LR Gaskin et al.   PSYCHOPHARMACOLOGY

Two grams of sarcosine in schizophrenia – is it too much? A potential role of glutamate- serotonin interaction

(2014) Dominik Strzelecki et al.   Neuropsychiatric Disease and Treatment

Glix 13, a New Drug Acting on Glutamatergic Pathways in Children and Animal Models of Autism Spectrum Disorders

(2014) Annamaria Chiara Santini et al.   Biomed Research International

Effect of Bitopertin, a Glycine Reuptake Inhibitor, on Negative Symptoms of Schizophrenia

(2014) Daniel Umbricht et al.   JAMA Psychiatry

Increasing effects of S-methyl-l-cysteine on the extracellular d-serine concentrations in the rat medial frontal cortex

(2013) Sayuri Ishiwata et al.   AMINO ACIDS

Serine racemase as a prime target for age-related memory deficits

(2013) J.-M. Billard   EUROPEAN JOURNAL OF NEUROSCIENCE

A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min

(2013) Patrizia Voehringer et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

In vitroCharacterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10)

(2013) Jeffrey M. Brown et al.   JOURNAL OF NEUROCHEMISTRY

Neuronal D-Serine and Glycine Release Via the Asc-1 Transporter Regulates NMDA Receptor-Dependent Synaptic Activity

(2013) D. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

(2013) Robert J. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

Towards improved animal models for evaluating social cognition and its disruption in schizophrenia: The CNTRICS initiative

(2013) Mark J. Millan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

NMDA-receptor coagonists in serum, plasma, and cerebrospinal fluid of schizophrenia patients: A meta-analysis of case–control studies

(2013) Annelies Brouwer et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

D-cycloserine in Prelimbic Cortex Reverses Scopolamine-Induced Deficits in Olfactory Memory in Rats

(2013) Marta Portero-Tresserra et al.   PLoS One

The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats

(2013) Allison L. McIntosh et al.   PSYCHOPHARMACOLOGY

The relationship between glycine transporter 1 occupancy and the effects of the glycine transporter 1 inhibitor RG1678 or ORG25935 on object retrieval performance in scopolamine impaired rhesus monkey

(2013) Donnie Eddins et al.   PSYCHOPHARMACOLOGY

Is D-Cycloserine a Prodrug for D-Serine in the Brain?

(2012) Mao Horio et al.   BIOLOGICAL PSYCHIATRY

5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms

(2012) S Woods et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

(2012) Julie Meffre et al.   EMBO Molecular Medicine

A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease

(2012) Katsuya Harada et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies

(2012) Scott W. Woods et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

The NMDA receptor as a target for cognitive enhancement

(2012) Graham L. Collingridge et al.   NEUROPHARMACOLOGY

Glycine Transporter Type 1 Occupancy by Bitopertin: a Positron Emission Tomography Study in Healthy Volunteers

(2012) Meret Martin-Facklam et al.   NEUROPSYCHOPHARMACOLOGY

A randomized, placebo-controlled laboratory study of the effects of d-cycloserine on craving in cocaine-dependent individuals

(2012) Kimber L. Price et al.   PSYCHOPHARMACOLOGY

D-Cycloserine Facilitates Socially Reinforced Learning in an Animal Model Relevant to Autism Spectrum Disorders

(2011) Meera E. Modi et al.   BIOLOGICAL PSYCHIATRY

Animal models of schizophrenia

(2011) CA Jones et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex

(2011) Pascal Fossat et al.   CEREBRAL CORTEX

Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment

(2011) David J. G. Watson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Simultaneous quantification of d- vs. l-serine, taurine, kynurenate, phosphoethanolamine and diverse amino acids in frontocortical dialysates of freely-moving rats: Differential modulation by N-methyl-d-aspartate (NMDA) and other pharmacological agents

(2011) Alain Gobert et al.   JOURNAL OF NEUROSCIENCE METHODS

Glycine reuptake inhibitor RG1678: A pharmacologic characterization of an investigational agent for the treatment of schizophrenia

(2011) Daniela Alberati et al.   NEUROPHARMACOLOGY

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

From Revolution to Evolution: The Glutamate Hypothesis of Schizophrenia and its Implication for Treatment

(2011) Bita Moghaddam et al.   NEUROPSYCHOPHARMACOLOGY

d-Cycloserine enhances spatial memory in spontaneous place recognition in rats

(2011) Takaaki Ozawa et al.   NEUROSCIENCE LETTERS

Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats

(2011) Makoto Bannai et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

Effects of low-dose d-serine on recognition and working memory in mice

(2011) Patricia Bado et al.   PSYCHOPHARMACOLOGY

Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice

(2010) Karla Kopec et al.   BIOCHEMICAL PHARMACOLOGY

Stereological brain volume changes in post-weaned socially isolated rats

(2010) Katrine Fabricius et al.   BRAIN RESEARCH

Serine racemase deletion disrupts memory for order and alters cortical dendritic morphology

(2010) L. M. DeVito et al.   GENES BRAIN AND BEHAVIOR

The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures

(2010) Mark J. Millan et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects

(2010) M Liem-Moolenaar et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Alterations in Brain Extracellular Dopamine and Glycine Levels Following Combined Administration of the Glycine Transporter Type-1 Inhibitor Org-24461 and Risperidone

(2010) Katalin Nagy et al.   NEUROCHEMICAL RESEARCH

Increased dopaminergic activity in socially isolated rats: An electrophysiological study

(2010) Katrine Fabricius et al.   NEUROSCIENCE LETTERS

d-Serine and a glycine transporter-1 inhibitor enhance social memory in rats

(2010) Toshiharu Shimazaki et al.   PSYCHOPHARMACOLOGY

Pharmacological characterization of social isolation-induced hyperactivity

(2010) Katrine Fabricius et al.   PSYCHOPHARMACOLOGY

The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat

(2010) Caitlin A. Jones et al.   PSYCHOPHARMACOLOGY

Object location memory in mice: Pharmacological validation and further evidence of hippocampal CA1 participation

(2009) Fabrício Luiz Assini et al.   BEHAVIOURAL BRAIN RESEARCH

Impairment in Long-Term Retention of Preference Conditioning in Schizophrenia

(2009) Ellen S. Herbener   BIOLOGICAL PSYCHIATRY

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

(2009) Jared W. Young et al.   PHARMACOLOGY & THERAPEUTICS

Increased dopamine D2Highreceptors in rats reared in social isolation

(2009) Madeleine V. King et al.   SYNAPSE

Blockade of dopamine D3 receptors in frontal cortex, but not in sub-cortical structures, enhances social recognition in rats: Similar actions of D1 receptor agonists, but not of D2 antagonists

(2008) Florence Loiseau et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

(2008) Kenneth W. Perry et al.   NEUROPHARMACOLOGY

Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats

(2008) M.I. Schubert et al.   NEUROSCIENCE

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

(2008) Kevin C.F. Fone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

d-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats

(2007) Jun-ichi Karasawa et al.   BEHAVIOURAL BRAIN RESEARCH

Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and d-serine

(2007) Kenji Hashimoto et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY