GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders

Specificity protein 4 (Sp4) regulates the transcription of AMPA receptor subunit GluA2 (Gria2)

(2014) Anusha Priya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Transcription factor Sp4 regulates expression of nervous wreck 2 to control NMDAR1 levels and dendrite patterning

(2014) Xinxin Sun et al.   Developmental Neurobiology

Developing treatments for cognitive deficits in schizophrenia: The challenge of translation

(2014) JW Young et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Relationship Between Glycine Transporter 1 Inhibition as Measured with Positron Emission Tomography and Changes in Cognitive Performances in Nonhuman Primates

(2014) S A Castner et al.   NEUROPSYCHOPHARMACOLOGY

Amotivation in Schizophrenia: Integrated Assessment With Behavioral, Clinical, and Imaging Measures

(2014) Daniel H. Wolf et al.   SCHIZOPHRENIA BULLETIN

The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology

(2014) Bruce N. Cuthbert   World Psychiatry

Specificity protein 4 functionally regulates the transcription of NMDA receptor subunits GluN1, GluN2A, and GluN2B

(2013) Anusha Priya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Isolation rearing effects on probabilistic learning and cognitive flexibility in rats

(2013) Nurith Amitai et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Anhedonia, avolition, and anticipatory deficits: Assessments in animals with relevance to the negative symptoms of schizophrenia

(2013) Samuel A. Barnes et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Reduced expression of SP1 and SP4 transcription factors in peripheral blood mononuclear cells in first-episode psychosis

(2013) Montserrat Fusté et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia

(2013) Athina Markou et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia

(2013) Baohu Ji et al.   PLoS One

Increased distractor vulnerability but preserved vigilance in patients with schizophrenia: Evidence from a translational Sustained Attention Task

(2013) Elise Demeter et al.   SCHIZOPHRENIA RESEARCH

Reverse translation of the rodent 5C-CPT reveals that the impaired attention of people with schizophrenia is similar to scopolamine-induced deficits in mice

(2013) J W Young et al.   Translational Psychiatry

Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research

(2013) A Der-Avakian et al.   Translational Psychiatry

Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: a roadmap for preclinical development

(2013) Dean T. Acheson et al.   Frontiers in Neuroscience

Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test

(2012) Jared W. Young et al.   BEHAVIOURAL BRAIN RESEARCH

Pharmacogenomics and Personalized Medicine in Neuropsychiatry

(2012) Francis J. McMahon et al.   NEURON

Revised associative inference paradigm confirms relational memory impairment in schizophrenia.

(2012) Kristan Armstrong et al.   NEUROPSYCHOLOGY

Glycine Transporter-1 Inhibition Preceding Extinction Training Inhibits Reacquisition of Cocaine Seeking

(2012) Cindy Achat-Mendes et al.   NEUROPSYCHOPHARMACOLOGY

Consideration of species differences in developing novel molecules as cognition enhancers

(2012) Jared W. Young et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

CNTRICS final animal model task selection: Control of attention

(2012) C. Lustig et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Poster #222 DELAYED “EUREKA” OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR KNOCKOUT MICE IN A PROBABILISTIC REVERSAL LEARNING PARADIGM

(2012) Jared W. Young et al.   SCHIZOPHRENIA RESEARCH

The glycine reuptake inhibitor Org24598 and acamprosate reduce ethanol intake in the rat; tolerance development to acamprosate but not to Org24598

(2011) Helga H. Lidö et al.   ADDICTION BIOLOGY

The transcription factor SP4 is reduced in postmortem cerebellum of bipolar disorder subjects: control by depolarization and lithium

(2011) Raquel Pinacho et al.   BIPOLAR DISORDERS

Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice

(2011) J. W. Young et al.   GENES BRAIN AND BEHAVIOR

Neural correlates of relational and item-specific encoding during working and long-term memory in schizophrenia

(2011) John D. Ragland et al.   NEUROIMAGE

CNTRICS Final Biomarker Selection: Control of Attention

(2011) S. J. Luck et al.   SCHIZOPHRENIA BULLETIN

CNTRICS Imaging Biomarkers Final Task Selection: Long-Term Memory and Reinforcement Learning

(2011) J. D. Ragland et al.   SCHIZOPHRENIA BULLETIN

Confirmed rare copy number variants implicate novel genes in schizophrenia

(2010) Gloria W.C. Tam et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Action of Modafinil—Increased Motivation Via the Dopamine Transporter Inhibition and D1 Receptors?

(2010) Jared W. Young et al.   BIOLOGICAL PSYCHIATRY

Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders

(2010) Xianjin Zhou et al.   HUMAN MOLECULAR GENETICS

Rethinking Mental Illness

(2010) Thomas R. Insel   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant

(2010) Tai-Xiang Xu et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study of recurrent early-onset major depressive disorder

(2010) J Shi et al.   MOLECULAR PSYCHIATRY

Altered probabilistic learning and response biases in schizophrenia: Behavioral evidence and neurocomputational modeling.

(2010) James A. Waltz et al.   NEUROPSYCHOLOGY

Serotonin Modulates Sensitivity to Reward and Negative Feedback in a Probabilistic Reversal Learning Task in Rats

(2010) Andrea Bari et al.   NEUROPSYCHOPHARMACOLOGY

Enhancement of Attentional Performance by Selective Stimulation of α4β2* nAChRs: Underlying Cholinergic Mechanisms

(2010) William M Howe et al.   NEUROPSYCHOPHARMACOLOGY

A Reverse-Translational Study of Dysfunctional Exploration in Psychiatric Disorders

(2009) William Perry et al.   ARCHIVES OF GENERAL PSYCHIATRY

Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators

(2009) Erin C. Dowd et al.   BIOLOGICAL PSYCHIATRY

The 5-Choice Continuous Performance Test: Evidence for a Translational Test of Vigilance for Mice

(2009) Jared W. Young et al.   PLoS One

Transcription Factor SP4 Is a Susceptibility Gene for Bipolar Disorder

(2009) Xianjin Zhou et al.   PLoS One

Reward Processing in Schizophrenia: A Deficit in the Representation of Value

(2008) J. M. Gold et al.   SCHIZOPHRENIA BULLETIN