Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of ‘schizophrenia-like’ behaviour in the rat

Hippocampal NMDA receptor blockade impairs CREB phosphorylation in amygdala after contextual fear conditioning

(2013) Cesar Augusto de Oliveira Coelho et al.   HIPPOCAMPUS

A “double hit” murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus

(2013) Javier Gilabert-Juan et al.   NEUROBIOLOGY OF DISEASE

The impact of adolescent social isolation on dopamine D2 and cannabinoid CB1 receptors in the adult rat prefrontal cortex

(2013) M.L. Fitzgerald et al.   NEUROSCIENCE

Increased Drinking following Social Isolation Rearing: Implications for Polydipsia Associated with Schizophrenia

(2013) Emily R. Hawken et al.   PLoS One

The atypical antipsychotic risperidone reverses the recognition memory deficits induced by post-weaning social isolation in rats

(2013) Allison L. McIntosh et al.   PSYCHOPHARMACOLOGY

Perinatal phencyclidine administration decreases the density of cortical interneurons and increases the expression of neuregulin-1

(2013) Nevena V. Radonjić et al.   PSYCHOPHARMACOLOGY

In Vivo Neurometabolic Profiling to Characterize the Effects of Social Isolation and Ketamine-Induced NMDA Antagonism: A Rodent Study at 7.0 T

(2013) Antonio Napolitano et al.   SCHIZOPHRENIA BULLETIN

Deficits in emotional learning and memory in an animal model of schizophrenia

(2012) Monica M. Bolton et al.   BEHAVIOURAL BRAIN RESEARCH

Estradiol attenuates the cognitive deficits in the novel object recognition task induced by sub-chronic phencyclidine in ovariectomized rats

(2012) Alexander S. Roseman et al.   BEHAVIOURAL BRAIN RESEARCH

Object recognition testing: Methodological considerations on exploration and discrimination measures

(2012) Sven Akkerman et al.   BEHAVIOURAL BRAIN RESEARCH

Myelination deficit in a phencyclidine-induced neurodevelopmental model of schizophrenia

(2012) Ruiguo Zhang et al.   BRAIN RESEARCH

5-HT6 receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms

(2012) S Woods et al.   BRITISH JOURNAL OF PHARMACOLOGY

5-HT6receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

(2012) Julie Meffre et al.   EMBO Molecular Medicine

Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats

(2012) Sanne S. Kaalund et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy

(2012) Mark J. Millan et al.   NATURE REVIEWS DRUG DISCOVERY

Post-weaning social isolation and subchronic NMDA glutamate receptor blockade: Effects on locomotor activity and GABA signaling in the rat suggest independent mechanisms

(2012) Andrea J. Hickey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Examination of ketamine-induced deficits in sensorimotor gating and spatial learning

(2012) Jonathan J. Sabbagh et al.   PHYSIOLOGY & BEHAVIOR

NMDA Receptor and Schizophrenia: A Brief History

(2012) J. T. Coyle   SCHIZOPHRENIA BULLETIN

Isolation rearing in rats: Effect on expression of synaptic, myelin and GABA-related immunoreactivity and its utility for drug screening via the subchronic parenteral route

(2011) Ann Li Lim et al.   BRAIN RESEARCH

Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment

(2011) David J. G. Watson et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The Role of 5-Hydroxytryptamine 7 Receptors in the Phencyclidine-Induced Novel Object Recognition Deficit in Rats

(2011) M. Horiguchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Selective Blockade of Dopamine D3 Receptors Enhances while D2 Receptor Antagonism Impairs Social Novelty Discrimination and Novel Object Recognition in Rats: A Key Role for the Prefrontal Cortex

(2011) David JG Watson et al.   NEUROPSYCHOPHARMACOLOGY

Time course of prepulse inhibition disruption induced by dopamine agonists and NMDA antagonists: Effects of drug administration regimen

(2011) Ming Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats

(2011) John P. Redrobe et al.   PSYCHOPHARMACOLOGY

Hippocampal interneurons are abnormal in schizophrenia

(2011) Christine Konradi et al.   SCHIZOPHRENIA RESEARCH

Isolation rearing-induced deficits in contextual fear learning do not require CRF2 receptors

(2010) Jodi E. Gresack et al.   BEHAVIOURAL BRAIN RESEARCH

Subchronic MK-801 treatment and post-weaning social isolation in rats: Differential effects on locomotor activity and hippocampal long-term potentiation

(2010) Donovan M. Ashby et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the rat

(2010) Samantha L. McLean et al.   BEHAVIOURAL BRAIN RESEARCH

Subchronic phencyclidine in rats: alterations in locomotor activity, maze performance, and GABAA receptor binding

(2010) Richard J. Beninger et al.   BEHAVIOURAL PHARMACOLOGY

All Roads to Schizophrenia Lead to Dopamine Supersensitivity and Elevated Dopamine D2High Receptors

(2010) Philip Seeman   CNS Neuroscience & Therapeutics

Changes in gene expression after phencyclidine administration in developing rats: a potential animal model for schizophrenia

(2010) F. Liu et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain

(2010) Shikha Snigdha et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Effect of isolation rearing on the expression of AMPA glutamate receptors in the hippocampal formation

(2010) Rodrigo S Sestito et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats

(2010) M.N. Quan et al.   NEUROSCIENCE

Increased dopaminergic activity in socially isolated rats: An electrophysiological study

(2010) Katrine Fabricius et al.   NEUROSCIENCE LETTERS

Peri-adolescence isolation rearing alters social behavior and nociception in rats

(2010) Qingxuan Meng et al.   NEUROSCIENCE LETTERS

Pharmacological characterization of social isolation-induced hyperactivity

(2010) Katrine Fabricius et al.   PSYCHOPHARMACOLOGY

The mGluR2/3 agonist LY379268 reverses post-weaning social isolation-induced recognition memory deficits in the rat

(2010) Caitlin A. Jones et al.   PSYCHOPHARMACOLOGY

Dissociation of acute and chronic intermittent phencyclidine-induced performance deficits in the 5-choice serial reaction time task: influence of clozapine

(2010) David M. Thomson et al.   PSYCHOPHARMACOLOGY

Prepulse inhibition and genetic mouse models of schizophrenia

(2009) Susan B. Powell et al.   BEHAVIOURAL BRAIN RESEARCH

Neonatal Phencyclidine Treatment in Mice Induces Behavioral, Histological and Neurochemical Abnormalities in Adulthood

(2009) Akiko Nakatani-Pawlak et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Impairment in Long-Term Retention of Preference Conditioning in Schizophrenia

(2009) Ellen S. Herbener   BIOLOGICAL PSYCHIATRY

The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical N-methyl-d-aspartate and D1 receptor binding in rats

(2009) C. Toua et al.   NEUROSCIENCE

Altered adult locomotor activity in rats from phencyclidine treatment on postnatal days 7, 9 and 11, but not repeated ketamine treatment on postnatal day 7

(2009) Sherin Y. Boctor et al.   NEUROTOXICOLOGY

Isolation rearing induces social and emotional function abnormalities and alters glutamate and neurodevelopment-related gene expression in rats

(2009) Xiaohong Zhao et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats

(2009) Takashi Uehara et al.   PSYCHOPHARMACOLOGY

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

(2009) O. D. Howes et al.   SCHIZOPHRENIA BULLETIN

Modeling the Positive Symptoms of Schizophrenia in Genetically Modified Mice: Pharmacology and Methodology Aspects

(2009) M. van den Buuse   SCHIZOPHRENIA BULLETIN

Increased dopamine D2Highreceptors in rats reared in social isolation

(2009) Madeleine V. King et al.   SYNAPSE

Identifying Cognitive Mechanisms Targeted for Treatment Development in Schizophrenia: An Overview of the First Meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative

(2008) Cameron S. Carter et al.   BIOLOGICAL PSYCHIATRY

Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats

(2008) SL McLean et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats

(2008) M.I. Schubert et al.   NEUROSCIENCE

Behavioural and neurochemical effects of post-weaning social isolation in rodents—Relevance to developmental neuropsychiatric disorders

(2008) Kevin C.F. Fone et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Atypical anti-schizophrenic drugs prevent changes in cortical N-methyl-d-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups

(2008) N ANASTASIO et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Perinatal PCP treatment alters the developmental expression of prefrontal and hippocampal muscarinic receptors

(2008) Teresa Marie du Bois et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat—a back translational study

(2008) Pascal Goetghebeur et al.   PSYCHOPHARMACOLOGY

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

(2008) Taku Nagai et al.   PSYCHOPHARMACOLOGY

Selecting Paradigms From Cognitive Neuroscience for Translation into Use in Clinical Trials: Proceedings of the Third CNTRICS Meeting

(2008) D. M. Barch et al.   SCHIZOPHRENIA BULLETIN

Chandelier cartridges in the prefrontal cortex are reduced in isolation reared rats

(2008) Claire Bloomfield et al.   SYNAPSE

Neonatal PCP Is More Potent than Ketamine at Modifying Preweaning Behaviors of Sprague-Dawley Rats

(2008) Sherin Y. Boctor et al.   TOXICOLOGICAL SCIENCES

Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat

(2007) Noelle C. Anastasio et al.   JOURNAL OF NEUROCHEMISTRY