Article
Neurosciences
Yiu Chung Tse, Moushumi Nath, Amanda Larosa, Tak Pan Wong
Summary: The impact of stress on learning and memory is mediated by plastic changes in glutamatergic transmission in the hippocampus. Acute stress enhances sNMDAR function but suppresses exNMDAR function, while chronic stress only reduces exNMDAR function. This suggests differential regulation of sNMDARs and exNMDARs by acute and chronic stress and highlights the potential roles of hippocampal exNMDARs in stress-related disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Neurosciences
Xiaona Liu, Jing Wang
Summary: Chronic arsenic exposure can lead to endemic arsenism and cognitive dysfunction, with NMDARs and their downstream signaling pathways playing a crucial role in synaptic plasticity impairment caused by arsenic exposure. Apart from improving water quality, potential therapeutic targets need to be identified.
Article
Biochemistry & Molecular Biology
Jean-Marie Billard, Thomas Freret
Summary: This study found that adding sAPP alpha significantly increased the activation of NMDAR in aged mice and rescued the deficit of long-term potentiation in these mice. The improvement of NMDAR in adult mice was also significantly increased with a higher concentration of sAPP alpha, but this effect was reduced in transgenic mice lacking the synthesizing enzyme serine racemase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor
Summary: This article reviews the roles of kainate receptors in synaptic plasticity, focusing on their impact on postsynaptic signaling and presynaptic auto-receptor functions. It also explores the plasticity of kainate receptors themselves and their contribution to synaptic transmission plasticity.
Review
Cell Biology
Wei-Feng Wu, Jia-Tao Lin, Yong-Kang Qiu, Shuai Li, Hui Zheng, Yu-Qing Wu
Summary: With the ageing of the population, the health problems of elderly individuals have become particularly important. Through a large number of clinical studies and trials, it has been confirmed that elderly patients can experience postoperative cognitive dysfunction after general anesthesia/surgery. However, the mechanism of postoperative cognitive dysfunction is still unknown. In recent years, the role of epigenetics in postoperative cognitive dysfunction has been widely studied and reported. This article summarizes the epigenetic mechanism of cognitive impairment after general anesthesia/surgery and analyses the broad prospects of epigenetics as a therapeutic target for postoperative cognitive dysfunction.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Rachel Price, Nicola Biagio Mercuri, Ada Ledonne
Summary: PARs, a unique class of GPCRs, play crucial roles in regulating neurotransmission and synaptic plasticity, particularly through modulating glutamatergic and GABAergic transmission. In normal conditions, PARs are important regulators of synaptic efficacy and plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Jesse E. Hanson, Hongjie Yuan, Riley E. Perszyk, Tue G. Banke, Hao Xing, Ming-Chi Tsai, Frank S. Menniti, Stephen F. Traynelis
Summary: N-methyl-D-aspartate (NMDA) receptors play a role in excitatory synaptic transmission, are present throughout the central nervous system, and are involved in synaptic plasticity. NMDA receptor modulators have shown potential in treating psychiatric disorders, neurodevelopmental disorders, and neurodegenerative conditions. Recent research has discovered that certain NMDA receptor inhibitors can rapidly and significantly alleviate depression by inducing long-lasting changes in the brain. This has led to new studies exploring the therapeutic applications of NMDA receptor antagonists. Positive allosteric modulators of NMDA receptors are also being investigated for enhancing synaptic function in diseases with NMDA receptor dysfunction. However, the use of NMDA receptor modulators comes with potential risks. Therefore, further research is needed to fully understand and harness the therapeutic potential of targeting this important receptor class.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sabyasachi Maity, Raman Abbaspour, David Nahabedian, Steven A. Connor
Summary: The noradrenergic system plays a crucial role in memory formation and synaptic plasticity. Norepinephrine stimulates beta-ARs to regulate memory formation and affects neural circuit function through epigenetic modifications. Understanding these mechanisms is essential for studying brain disorders and developing neurotherapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Yi-Shiou Tseng, Chun-Hou Liao, Wen-Bin Wu, Ming-Chieh Ma
Summary: The study demonstrates that NMDAR blockade alleviates D-serine-induced renal injury, possibly through the involvement of NOX4-mediated oxidative stress. These findings have important implications for preventing acute renal injury caused by D-serine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ilaria Bertocchi, Florbela Rocha-Almeida, Maria Teresa Romero-Barragan, Marco Cambiaghi, Alejandro Carretero-Guillen, Paolo Botta, Godwin K. Dogbevia, Mario Trevino, Paolo Mele, Alessandra Oberto, Matthew E. Larkum, Agnes Gruart, Rolf Sprengel, Jose Maria Delgado-Garcia, Mazahir T. Hasan
Summary: The organization and formation of fear memory involve multiple brain regions. The activity of NMDARs plays a crucial role in fear memory formation, and the consolidation of multi-trace systems is essential for the sequential printing and flexible retrieval of fear memory.
Article
Biology
Yuri Elias Rodrigues, Cezar M. Tigaret, Helene Marie, Cian O'Donnell, Romain Veltz
Summary: Discovering the rules of synaptic plasticity is crucial for understanding brain learning. Existing models either lack flexibility to fit experimental data or are too complex to interpret. To overcome these limitations, we propose a new plasticity rule based on a geometrical readout mechanism that accurately predicts plasticity outcomes. Our model successfully reproduces various experimental conditions and suggests that spike timing irregularity strongly affects plasticity outcome. This modelling approach can be applied to other synapses to discover their plasticity rules.
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Neurosciences
Rong Ma, Eric Hanse, Bengt Gustafsson
Summary: When activated at low frequencies, synapses onto the most distal part of the apical dendritic tree of rat hippocampal CA1 pyramidal cells display a frequency-dependent synaptic depression. This depression, thought to contribute to behavioral habituation, affects both low and high-frequency synaptic transmissions and is intrinsic to the synapses themselves. The depression is proposed to be caused by a release-independent process involving inactivation of release sites with a fast onset and long duration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)