Article
Psychiatry
William G. Warren, Ed Hale, Eleni P. Papagianni, Helen J. Cassaday, Carl W. Stevenson, Christine Stubbendorff
Summary: The study investigated the effects of the endocannabinoid metabolism inhibitor URB597 on social and non-social memory in Lister Hooded rats. While URB597 did not impact memory, it did have subtle effects on social behavior during social interaction testing. This highlights the importance of considering strain and behavioral composition when studying drug effects on social behavior.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
William G. Warren, Eleni P. Papagianni, Ed Hale, Rebecca A. Brociek, Helen J. Cassaday, Carl W. Stevenson
Summary: Endocannabinoid transmission plays an important role in treating anxiety-related disorders through the regulation of fear extinction. The inhibition of FAAH can enhance extinction by increasing anandamide levels, while inhibiting MAGL can impair extinction by elevating 2-arachidonoylglycerol levels. However, the specific effects of endocannabinoids on fear relapse and extinction resistance are still uncertain.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Ryo Utsunomiya, Kanta Mikami, Tomomi Doi, Mohammed E. Choudhury, Toshihiro Jogamoto, Naohito Tokunaga, Eiichi Ishii, Mariko Eguchi, Hajime Yano, Junya Tanaka
Summary: In addition to genetic factors, environmental factors also play a significant role in the development of attention deficit/hyperactivity disorder (ADHD). This study used Lister hooded rats as ADHD model animals and found that environmental conditions had a notable impact on the behavior and neural activity of the rats. Specifically, rats raised in an enriched environment showed improved ADHD-like behaviors, which were associated with reduced neuronal activity in the medial prefrontal cortex.
Article
Multidisciplinary Sciences
Wojciech Pisula, Klaudia Modlinska, Anna Chrzanowska, Katarzyna Goncikowska
Summary: This study investigates the relationship between changes in size and complexity of familiar objects and the exploratory activity regulation in rats. The rats responded to new tunnels with increased exploration, initially reacted to changes in size but then refocused, and showed pronounced curiosity towards increased complexity. The data suggests that curiosity in rats is at least two-dimensional: activational and cognitive.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Nikita Tjernstrom, Tie-Qiang Li, Sarah Holst, Erika Roman
Summary: This study examined the relationship between gambling strategies and behavioral and neural correlates using the rat Gambling Task (rGT). The results showed that rats displayed stable gambling strategies in the rGT, which were associated with brain regions important for reward networks. Additionally, rats with risky gambling strategies differed in brain functional connectivity from those with strategic and intermediate strategies.
Article
Multidisciplinary Sciences
Xuelong Zhou, Xiaolu Zhou, Chenjing Zhang
Summary: This study aimed to investigate the effect of long-term social isolation on visceral pain sensitivity in rats. The results showed that social isolation increased the sensitivity to visceral pain in rats, and this effect was unrelated to an increase in stress levels.
Article
Clinical Neurology
Helene A. Fachim, Fabiana Corsi-Zuelli, Camila M. Loureiro, Sri-arun Iamjan, Rosana Shuhama, Samia Joca, Paulo Rossi Menezes, Adrian Heald, Paulo Louzada-Junior, Caroline F. Dalton, Cristina Marta Del-Ben, Gavin P. Reynolds
Summary: The study suggests that childhood maltreatment may result in increased BDNF methylation, providing a mechanism underlying the association between early-life stress and psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Domenico Giacco, James B. Kirkbride, Anna O. Ermakova, Martin Webber, Penny Xanthopoulou, Stefan Priebe
Summary: The study found that patients with psychosis in urban areas are more socially isolated when surrounded by more people, which could impact their clinical outcomes. There were no associations found between social contacts or satisfaction with friendships with social deprivation or fragmentation indexes.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Behavioral Sciences
Saeideh Davari, Nicole 'Costa, Reza Ramezan, John G. Mielke
Summary: Social adversity during childhood and adolescence may increase the likelihood of mental illnesses. A study on rats using the Chronic Early-Life Social Isolation (CELSI) model found that rats who experienced post-weaning social isolation showed stronger spatial learning and memory abilities. The study also observed an increase in expression of PSD-95, a key neuronal protein, in socially isolated male rats. These findings suggest that CELSI may enhance hippocampal-dependent behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Medicine, Research & Experimental
Maria Bove, Adriano Lama, Stefania Schiavone, Claudio Pirozzi, Paolo Tucci, Vladyslav Sikora, Giovanna Trinchese, Gaetano Corso, Maria Grazia Morgese, Luigia Trabace
Summary: Social isolation-induced insulin resistance and oxidative stress may contribute to disturbances in glucose homeostasis and metabolic impairment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Veterinary Sciences
Justyna K. Hinchcliffe, Megan G. Jackson, Emma S. J. Robinson
Summary: The advancement and quality of science rely on robust and unbiased research. This study found that using ball pits and playpens can increase animals' positive emotions and improve the welfare of laboratory rats.
LABORATORY ANIMALS
(2022)
Article
Neurosciences
Suzanne Estaphan, Alexandrina-Stefania Curpan, Dalia Khalifa, Laila Rashed, Andrei Ciobica, Adrian Cantemir, Alin Ciobica, Constantin Trus, Mahmoud Ali, Asmaa ShamsEldeen
Summary: This study examined the effects of ketamine administration combined with isolation in inducing schizophrenia-like symptoms in male albino rats. Results showed significant differences in behavior tests and oxidative stress levels between the ketamine + isolation group and the control or ketamine + social housing group. Additionally, adding aripiprazole treatment to the ketamine + social isolation group further reduced positive schizophrenia-like symptoms. This research suggests a potential model capable of illustrating both positive and negative symptoms of schizophrenia.
Review
Medicine, General & Internal
Mehmet Kanbay, Cem Tanriover, Sidar Copur, Ibrahim B. B. Peltek, Ali Mutlu, Francesca Mallamaci, Carmine Zoccali
Summary: Social isolation and loneliness are often overlooked conditions that have a negative impact on quality of life, overall health, and mortality. This review discusses the health consequences of these conditions, including potential causes, pathophysiological processes, associations with non-communicable diseases, and effects on health-related behaviors. It also explores current and novel management strategies. Healthcare professionals should be knowledgeable about social isolation and loneliness, thoroughly assess patients, and provide education and treatment options through shared decision-making. Further research is needed to better understand the underlying mechanisms and improve treatment strategies for these conditions.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Behavioral Sciences
Alexander A. Moghadam, Linnea R. Vose, Omid Miry, Xiao-Lei Zhang, Patric K. Stanton
Summary: The combination of neonatal PCP exposure and acute adolescent stress leads to lasting cognitive impairment and anxiety-like phenotype in rodents, potentially due to deficits in LTP in the hippocampus and elsewhere in the brain.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Microbiology
Bing Hu, Promi Das, Xianglin Lv, Meng Shi, Jiye Aa, Kun Wang, Liping Duan, Jack A. Gilbert, Yong Nie, Xiao-Lei Wu
Summary: Depression is a common mood disorder affecting over 260 million people worldwide. Dysbiosis of the gut microbiome, which modulates neuro-biochemical metabolism through the microbiome-gut-brain axis, has been associated with the development of depressive-like behaviors. Fecal microbiota transplantation (FMT) has been proposed as a potential therapeutic solution for depression, and this study investigated its therapeutic efficiency and mechanisms.
Article
Clinical Neurology
Elisabeth H. L. Rusholt, Lisette Salvesen, Tomasz Brudek, Betel Tesfay, Bente Pakkenberg, Mikkel V. Olesen
Correction
Neurosciences
Morgane Thomsen, Jens Juul Holst, Anna Molander, Kristian Linnet, Maurice Ptito, Anders Fink-Jensen
PSYCHOPHARMACOLOGY
(2020)
Article
Psychology, Clinical
Ditte Ruda, Gudmundur Einarsson, Jannik Boll Matthiassen, Christoph U. Correll, Karsten Gjessing Jensen, Dea Gowers Klauber, Clara Josefine Richard, Anne Sofie Schott Andersen, Sabrina Kroigaard, Jens Richardt Mollegaard Jepsen, Birgitte Fagerlund, Kristian Winge, Line K. H. Clemmesen, Anne Katrine Pagsberg, Rasmus R. Paulsen, Anders Fink-Jensen
CHILD AND ADOLESCENT MENTAL HEALTH
(2020)
Article
Neurosciences
Sanne Simone Kaalund, Annette Johansen, Katrine Fabricius, Bente Pakkenberg
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Mathias E. Jensen, Aurelio Galli, Morgane Thomsen, Kathrine L. Jensen, Gerda K. Thomsen, Mette K. Klausen, Tina Vilsboll, Mikkel B. Christensen, Jens J. Holst, Anthony Owens, Sabrina Robertson, Lynette Daws, Daniele Zanella, Ulrik Gether, Gitte M. Knudsen, Anders Fink-Jensen
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Psychology, Clinical
Birgitte Fagerlund, Christos Pantelis, Jens Richardt Mollegaard Jepsen, Jayachandra Mitta Raghava, Egill Rostrup, Marie Bjerregaard Thomas, Mette Odegaard Nielsen, Kirsten Bojesen, Karsten Gjessing Jensen, Marie Stentebjerg-Decara, Dea Gowers Klauber, Ditte Ruda, Bjorn H. Ebdrup, Kasper Jessen, Anne Sigvard, Karen Tangmose, Pia Jeppesen, Christoph U. Correll, Anders Fink-Jensen, Anne Katrine Pagsberg, Birte Yding Glenthoj
Summary: The study found that there are different impacts of age on cognition among patients with early and late onset schizophrenia, particularly in verbal memory and digit sequencing. This suggests a potential interaction between neurodevelopmental maturation timing and cognitive functioning in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Neurosciences
Rasmus Rydbirk, Jonas Folke, Florence Busato, Elodie Roche, Alisha Shahzad Chauhan, Annemette Lokkegaard, Anne-Mette Hejl, Matthias Bode, Morten Blaabjerg, Mette Moller, Erik Hvid Danielsen, Tomasz Brudek, Bente Pakkenberg, Jorg Tost, Susana Aznar
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Article
Behavioral Sciences
Jessica Justinussen, Camilla Dall, Ditte Dencker, Albert Gjedde, Anders Fink-Jensen, Morgane Thomsen
BEHAVIOURAL BRAIN RESEARCH
(2020)
Review
Psychiatry
Magnus G. Christensen, Jakob Damsgaard, Anders Fink-Jensen
Summary: This systematic review investigates the use and efficacy of ketogenic diets, modified Atkins diet, and medium-chain triglyceride diet in patients with epilepsy, Alzheimer's disease, and Parkinson's disease. The results show that ketogenic diets can reduce seizures in epilepsy patients, modified Atkins diet can improve memory in Alzheimer's patients, and medium-chain triglyceride diet can enhance motor and nonmotor functions in Parkinson's patients.
NORDIC JOURNAL OF PSYCHIATRY
(2021)
Correction
Multidisciplinary Sciences
Rasmus Rydbirk, Jonas Folke, Kristian Winge, Susana Aznar, Bente Pakkenberg, Tomasz Brudek
SCIENTIFIC REPORTS
(2020)
Article
Psychiatry
Anto P. Rajkumar, Per Qvist, Julie G. Donskov, Ross Lazarus, Jonatan Pallesen, Nicoletta Nava, Gudrun Winther, Nico Liebenberg, Sanne H. la Cour, Veerle Paternoster, Tue Fryland, Johan Palmfeldt, Kim Fejgin, Arne Mork, Mette Nyegaard, Bente Pakkenberg, Michael Didriksen, Jens R. Nyengaard, Gregers Wegener, Ole Mors, Jane H. Christensen, Anders D. Borglum
TRANSLATIONAL PSYCHIATRY
(2020)
Article
Clinical Neurology
Marco Moller, Simon Fredholm, Mathias E. Jensen, Gitta Wortwein, Julie R. Larsen, Tina Vilsboll, Niels Odum, Anders Fink-Jensen
Summary: The study aimed to evaluate the relationship between the therapeutic effects of glucagon-like peptide-1 receptor agonist liraglutide and cytokines. The results showed that prediabetic patients treated with clozapine or olanzapine had increased levels of inflammatory cytokines in their serum, further confirming the link between inflammation and type 2 diabetes. However, treatment with liraglutide did not affect these cytokines.
Review
Pharmacology & Pharmacy
Mette Kruse Klausen, Morgane Thomsen, Gitta Wortwein, Anders Fink-Jensen
Summary: Drug, alcohol and tobacco use disorders are a global burden. GLP-1 receptor agonists have potential as anti-addiction treatment. Animal and clinical studies have shown a reduction in alcohol and drug abuse with GLP-1 treatment.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mikkel Hojlund, Christina Blanner Wagner, Rikke Wesselhoeft, Kjeld Andersen, Anders Fink-Jensen, Jesper Hallas
Summary: This study found that low-dose chlorprothixene use is associated with increased risk of diabetes and cardiovascular adverse events compared with low-dose quetiapine use.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan M. Sattler, Anniek F. Lubberding, Charlotte B. Kristensen, Rasmus Mogelvang, Paul Blanche, Anders Fink-Jensen, Thomas Engstrom, Stefan Kaab, Thomas Jespersen, Jacob Tfelt-Hansen
IJC HEART & VASCULATURE
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
