Review
Pharmacology & Pharmacy
Daniel C. Javitt
Summary: Cognitive impairment is a prominent feature of schizophrenia, and its assessment methods are well established. The role of social cognitive impairment and sensory-level dysfunction in functional outcomes has also been recognized. Treatment development targeting N-methyl-d-aspartate receptor (NMDAR) and its associated impairments has become encouraging. Mismatch negativity has emerged as a promising biomarker for early-stage drug development in schizophrenia.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Neurosciences
Deborah K. Park, Samuel Petshow, Margarita Anisimova, Eden V. Barragan, John A. Gray, Ivar S. Stein, Karen Zito
Summary: This study shows that decreased D-serine levels associated with schizophrenia enhance ion flux-independent NMDAR signaling, leading to destabilized dendritic spines. This hypothesis was tested using the serine racemase knockout mouse model and the results support the hypothesis.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Environmental Sciences
Mohsen Shamsi, Maliheh Soodi, Shirin Shahbazi, Ameneh Omidi
Summary: The study found that Acetamiprid reduces glutamate levels, affects the expression of NMDA receptor subunits in the hippocampus, leading to impaired memory consolidation at low doses, and loss of neural cells in the dentate gyrus area at high doses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Medicinal
Fabao Zhao, Unai Atxabal, Sofia Mariottini, Feng Yi, James S. Lotti, Nirvan Rouzbeh, Na Liu, Lennart Bunch, Kasper B. Hansen, Rasmus P. Clausen
Summary: The design and synthesis of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid analogues as agonists at the glycine binding site in the GluN1 subunit of NMDA receptors were described. These novel analogues show variable potencies and agonist efficacies among different NMDA receptor subtypes, providing new opportunities for the development of therapeutic agents that can modulate specific NMDA receptor subtypes.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Clinical Neurology
Pooja Patnaik Kuppili, Vikas Menon, Gopinath Sathyanarayanan, Siddharth Sarkar, Chittaranjan Andrade
Summary: This study found that d-Cycloserine did not show significant efficacy in treating negative, cognitive, or positive symptoms of schizophrenia. Additionally, there was no significant improvement in early treatment outcomes.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Psychiatry
Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D'Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Summary: The study suggests that D-aspartate plays an important role in neurodevelopment and functioning, and the dysmetabolism of D-aspartate is associated with neurodevelopmental disorders such as schizophrenia. Using a mouse model, the researchers found that early occurrence of D-aspartate can influence neurodevelopment and lead to social recognition memory deficits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Nafsika Poulia, Foteini Delis, Charalampos Brakatselos, Alexia Polissidis, Yassemi Koutmani, Nikolaos Kokras, Christina Dalla, Panagiotis K. Politis, Katerina Antoniou
Summary: Adolescent low-dose THC exposure negatively impacts psychomotor profile, dopaminergic neurotransmission, compensatory cannabinoid receptor response, cognition-related neurobiological, and behavioral functions.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Kah Kheng Goh, Tzu-Hua Wu, Chun-Hsin Chen, Mong-Liang Lu
Summary: In patients with schizophrenia, N-methyl-D-aspartate receptor modulator supplements, when used in conjunction with antipsychotic medications, can improve certain symptoms, particularly negative symptoms, with satisfactory side effects and safety profiles.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Review
Psychiatry
Magdalena Orzylowski, Esther Fujiwara, Darrell D. Mousseau, Glen B. Baker
Summary: Dementia, including Alzheimer's disease, is characterized by progressive cognitive deterioration with profound memory loss. D-serine plays a crucial role in the activation of NMDAR and regulation of learning and memory, making it important for both normal aging and dementia.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
E. Ploux, T. Freret, J-M Billard
Summary: As people age, communication and plasticity between neurons weaken, with NMDAr activation playing a crucial role in brain plasticity. D-serine may contribute to mechanisms of physiological cognitive aging.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Review
Neurosciences
Qiongqiong Wu, Jing Huang, Renrong Wu
Summary: The NMDAR hypofunction hypothesis offers a new perspective for treating negative symptoms and cognitive dysfunction in schizophrenia, with drugs targeting this receptor showing promise in improving symptoms. However, unsatisfactory outcomes in clinical studies suggest further research is needed to effectively utilize this hypothesis.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Chae-Seok Lim, Min Jung Kim, Ja Eun Choi, Md Ariful Islam, You-Kyung Lee, Yinyi Xiong, Kyu-Won Shim, Jung-eun Yang, Ro Un Lee, Jiah Lee, Pojeong Park, Ji-Hye Kwak, Hyunhyo Seo, Chul Hoon Kim, Jae-Hyung Lee, Yong-Seok Lee, Su-Kyeong Hwang, Kyungmin Lee, Jin-A Lee, Bong-Kiun Kaang
Summary: Heterogeneity in the etiopathology of autism spectrum disorders (ASD) requires individualistic and patient-specific research. Recent progress in human-induced pluripotent stem cell (iPSC) technology provides a novel platform for studying complex neuronal phenotypes. The study found that DSCAM mutation causes pathological symptoms of ASD by dysregulating NMDA-R function.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Neurosciences
Sebastiano A. Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggio
Summary: Several studies have shown that chronic stress has a negative effect on recognition memory, but the effects of acute stress on this cognitive ability have not been well studied. This study aimed to investigate the impact of acute stress on recognition memory consolidation in a sex-dependent manner. The results showed that acute stress did not affect memory performance in male and female mice immediately after training, but it altered memory performance after a 24-hour delay, with sex-dependent effects.
NEUROBIOLOGY OF STRESS
(2023)
Article
Biochemistry & Molecular Biology
Xue-Jia Qi, Chong-Yin Huang, Meng-Ting Zuo, Meng-Die Gong, Si-Juan Huang, Mo-Huan Tang, Zhao-Ying Liu
Summary: In this study, a combination of network pharmacology and experimental verification was used to systematically explore the toxic mechanism of Gelsemium. The toxicity of Gelsemium was found to be mainly related to protein phosphorylation reaction and plasma membrane function. Molecular docking revealed the high affinity between Gelsemium alkaloids and key targets, and animal experiments confirmed the potential mechanisms of Gelsemium toxicity. This research provides a theoretical basis for further understanding the toxic mechanism of Gelsemium and developing potential therapeutic strategies for Gelsemium poisoning.