GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

Replication of Ketamine's Antidepressant Efficacy in Bipolar Depression: A Randomized Controlled Add-On Trial

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors

(2011) J. Burgdorf et al.   NEUROSCIENCE

A Randomized Add-on Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Bipolar Depression

(2010) Nancy Diazgranados et al.   ARCHIVES OF GENERAL PSYCHIATRY

Hippocampal synaptic metaplasticity requires the activation of NR2B-containing NMDA receptors

(2010) Qian Yang et al.   BRAIN RESEARCH BULLETIN

Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder

(2010) Nancy DiazGranados et al.   JOURNAL OF CLINICAL PSYCHIATRY

Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I

(2010) J. Burgdorf et al.   NEUROSCIENCE

Ketamine impairs recognition memory consolidation and prevents learning-induced increase in hippocampal brain-derived neurotrophic factor levels

(2010) B.K. Goulart et al.   NEUROSCIENCE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Effects of Intravenous Ketamine on Explicit and Implicit Measures of Suicidality in Treatment-Resistant Depression

(2009) Rebecca B. Price et al.   BIOLOGICAL PSYCHIATRY

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

(2009) Marije aan het Rot et al.   BIOLOGICAL PSYCHIATRY

The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

(2009) Jeffrey Burgdorf et al.   NEUROBIOLOGY OF AGING

Neuroprotection by a novel NMDAR functional glycine site partial agonist, GLYX-13

(2009) Patric K. Stanton et al.   NEUROREPORT

The Role of the Tripartite Glutamatergic Synapse in the Pathophysiology and Therapeutics of Mood Disorders

(2009) Rodrigo Machado-Vieira et al.   NEUROSCIENTIST

The discriminative stimulus effects of N-methyl-d-aspartate glycine-site ligands in NMDA antagonist-trained rats

(2009) Katherine L. Nicholson et al.   PSYCHOPHARMACOLOGY

Glutamate-based antidepressants: 20 years on

(2009) Phil Skolnick et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The effects of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats

(2008) Jeffrey Burgdorf et al.   DEVELOPMENTAL PSYCHOBIOLOGY

Metaplasticity: tuning synapses and networks for plasticity

(2008) Wickliffe C. Abraham   NATURE REVIEWS NEUROSCIENCE

A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus

(2008) Xiao-lei Zhang et al.   NEUROPHARMACOLOGY

Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist

(2008) Paul L. Wood et al.   NEUROREPORT

Reduced levels of NR2A and NR2B subunits of NMDA receptor and PSD-95 in the prefrontal cortex in major depression

(2008) Anteneh M. Feyissa et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

(2007) Sungho Maeng et al.   BIOLOGICAL PSYCHIATRY