mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update

Epilepsy in adults

(2019) Roland D Thijs et al.   LANCET

mTOR Hyperactivity Levels Influence the Severity of Epilepsy and Associated Neuropathology in an Experimental Model of Tuberous Sclerosis Complex and Focal Cortical Dysplasia

(2019) Lena H. Nguyen et al.   JOURNAL OF NEUROSCIENCE

The role of somatic mutational events in the pathogenesis of epilepsy

(2019) Philip H. Iffland et al.   CURRENT OPINION IN NEUROLOGY

Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity

(2019) Fiona Limanaqi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior

(2019) Kelvin K. Hui et al.   Science Advances

Relationship of Antiphospholipid Antibodies to Risk of Dementia: A Systematic Review

(2019) Tommaso Bucci et al.   JOURNAL OF ALZHEIMERS DISEASE

The effects of proteasome on baseline and methamphetamine-dependent dopamine transmission

(2019) Fiona Limanaqi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

LC3-positive structures are prominent in autophagy-deficient cells

(2019) Gautam Runwal et al.   Scientific Reports

Therapeutic potential of endothelial progenitor cells in a rat model of epilepsy: Role of autophagy

(2019) Shimaa O. Ali et al.   Journal of Advanced Research

Prevention of post-ischemic seizure by rapamycin is associated with deactivation of mTOR and ERK1/2 pathways in hyperglycemic rats

(2019) Xiao Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Autophagy Status of Cancer Stem Cells in Gliobastoma Multiforme: From Cancer Promotion to Therapeutic Strategies

(2019) Larisa Ryskalin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Ibuprofen on Autophagy of Astrocytes During Pentylenetetrazol-Induced Epilepsy and its Significance: An Experimental Study

(2019) Jiangtao Peng et al.   NEUROCHEMICAL RESEARCH

Mechanistic target of rapamycin (mTOR) signaling in status epilepticus

(2019) Peter B. Crino   EPILEPSY & BEHAVIOR

Molecular Mechanisms Linking ALS/FTD and Psychiatric Disorders, the Potential Effects of Lithium

(2019) Fiona Limanaqi et al.   Frontiers in Cellular Neuroscience

Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures

(2018) Bao-Hui Wang et al.   BRAIN RESEARCH

The anticonvulsant activity and cerebral protection of chronic lithium chloride via NMDA receptor/nitric oxide and phospho-ERK

(2018) Razieh Mohammad Jafari et al.   BRAIN RESEARCH BULLETIN

Dramatic relapse of seizures after everolimus withdrawal

(2018) Alessia Mingarelli et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs

(2018) Thea P. Lillethorup et al.   EXPERIMENTAL NEUROLOGY

Ulk2 controls cortical excitatory–inhibitory balance via autophagic regulation of p62 and GABAA receptor trafficking in pyramidal neurons

(2018) Akiko Sumitomo et al.   HUMAN MOLECULAR GENETICS

Dopamine Receptor Subtypes Differentially Regulate Autophagy

(2018) Dongmei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy Enhances Memory Erasure through Synaptic Destabilization

(2018) Mohammad Shehata et al.   JOURNAL OF NEUROSCIENCE

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Evaluation of ATG5 polymorphisms in Italian patients with systemic lupus erythematosus: contribution to disease susceptibility and clinical phenotypes

(2018) C Ciccacci et al.   LUPUS

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia

(2018) Guo‑Shuai Yang et al.   Molecular Medicine Reports

Roles for neuronal and glial autophagy in synaptic pruning during development

(2018) Ori J. Lieberman et al.   NEUROBIOLOGY OF DISEASE

Sitagliptin enhances the neuroprotective effect of pregabalin against pentylenetetrazole-induced acute epileptogenesis in mice: Implication of oxidative, inflammatory, apoptotic and autophagy pathways

(2018) Manar A. Nader et al.   NEUROCHEMISTRY INTERNATIONAL

Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis

(2018) A. J. Becker   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Autophagy at the synapse

(2018) Veronica Birdsall et al.   NEUROSCIENCE LETTERS

mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine

(2018) Shin-Han Huang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Baicalin reverses the impairment of synaptogenesis induced by dopamine burden via the stimulation of GABAAR–TrkB interaction in minimal hepatic encephalopathy

(2018) Saidan Ding et al.   PSYCHOPHARMACOLOGY

Metabolism as a Target for Modulation in Autoimmune Diseases

(2018) Nick Huang et al.   TRENDS IN IMMUNOLOGY

Cortical GABAergic Interneuron/Progenitor Transplantation as a Novel Therapy for Intractable Epilepsy

(2018) Qian Zhu et al.   Frontiers in Cellular Neuroscience

Rapamycin provides anti‑epileptogenic effect in a rat model of post‑traumatic epilepsy via deactivation of mTOR signaling pathway

(2018) Feng Wang et al.   Experimental and Therapeutic Medicine

Lithium affects rat hippocampal electrophysiology and epileptic seizures in a dose dependent manner

(2018) Guohui Jiang et al.   EPILEPSY RESEARCH

Ambiguous Effects of Autophagy Activation Following Hypoperfusion/Ischemia

(2018) Michela Ferrucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

(2018) Fiona Limanaqi et al.   Oxidative Medicine and Cellular Longevity

Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice

(2018) Jingqi Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interdependency Between Autophagy and Synaptic Vesicle Trafficking: Implications for Dopamine Release

(2018) Fiona Limanaqi et al.   Frontiers in Molecular Neuroscience

Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases

(2018) Florent Arbogast et al.   Frontiers in Immunology

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems

(2018) Gloria Lazzeri et al.   Oxidative Medicine and Cellular Longevity

Seizures as a clinical manifestation in somatic autoimmune disorders

(2018) Man Amanat et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

(2018) Katerina Gkirtzimanaki et al.   Cell Reports

Severe infantile onset developmental and epileptic encephalopathy caused by mutations in autophagy gene WDR45

(2017) Gemma L. Carvill et al.   EPILEPSIA

Increased expression of (immuno)proteasome subunits during epileptogenesis is attenuated by inhibition of the mammalian target of rapamycin pathway

(2017) Diede W. M. Broekaart et al.   EPILEPSIA

Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation

(2017) Arindam Ghosh Mazumder et al.   JOURNAL OF ETHNOPHARMACOLOGY

Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid

(2017) Soraya Wilke Saliba et al.   Journal of Neuroinflammation

Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy

(2017) Shu-Hui Chuang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury

(2017) James P. Reynolds et al.   NEUROCHEMICAL RESEARCH

Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway

(2017) Yuliang Wang et al.   NEUROREPORT

Role of Akt-independent mTORC1 and GSK3β signaling in sublethal NMDA-induced injury and the recovery of neuronal electrophysiology and survival

(2017) Przemyslaw Swiatkowski et al.   Scientific Reports

Rapamycin Attenuates Acute Seizure-induced Astrocyte Injury in Mice in Vivo

(2017) Dongjun Guo et al.   Scientific Reports

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Sexual dimorphism of AMBRA1-related autistic features in human and mouse

(2017) M Mitjans et al.   Translational Psychiatry

ATGs help MHC class II, but inhibit MHC class I antigen presentation

(2016) Monica Loi et al.   Autophagy

FoxO3a-mediated autophagy is down-regulated in the laforin deficient mice, an animal model for Lafora progressive myoclonus epilepsy

(2016) Navodita Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses

(2016) Andrea K.H. Stavoe et al.   DEVELOPMENTAL CELL

Autophagy proteins in antigen processing for presentation on MHC molecules

(2016) Christian Münz   IMMUNOLOGICAL REVIEWS

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development

(2016) J. van Scheppingen et al.   Journal of Neuroinflammation

The Enigma of Rapamycin Dosage

(2016) S. Mukhopadhyay et al.   MOLECULAR CANCER THERAPEUTICS

Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy

(2016) Xueqin Wang et al.   MOLECULAR NEUROBIOLOGY

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Seizures and gliomas — towards a single therapeutic approach

(2016) Gilles Huberfeld et al.   Nature Reviews Neurology

Valproic acid induces autophagy by suppressing the Akt/mTOR pathway in human prostate cancer cells

(2016) Qinghua Xia et al.   Oncology Letters

The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions

(2016) Paola Lenzi et al.   Frontiers in Neuroanatomy

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8 + T Cell Responses

(2016) Monica Loi et al.   Cell Reports

Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice

(2016) Zachary Oaks et al.   Arthritis & Rheumatology

The autophagy geneWdr45/Wipi4regulates learning and memory function and axonal homeostasis

(2015) Yan G Zhao et al.   Autophagy

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy

(2015) Michele Mishto et al.   BRAIN BEHAVIOR AND IMMUNITY

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks

(2015) Roberta Pennucci et al.   CEREBRAL CORTEX

Defective autophagy is a key feature of cerebral cavernous malformations

(2015) Saverio Marchi et al.   EMBO Molecular Medicine

Intermittent dosing of rapamycin maintains antiepileptogenic effects in a mouse model of tuberous sclerosis complex

(2015) Nicholas Rensing et al.   EPILEPSIA

Reciprocal Regulation of AMP-activated Protein Kinase and Phospholipase D

(2015) Suman Mukhopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Axonal Accumulation of Lysosomal-Associated Membrane Protein 1 (LAMP1) Accompanying Alterations of Autophagy Dynamics in the Rat Hippocampus Upon Seizure-Induced Injury

(2015) A. Rami et al.   NEUROCHEMICAL RESEARCH

Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish

(2015) Anna Maria Siebel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The role of ubiquitin/Nedd4-2 in the pathogenesis of mesial temporal lobe epilepsy

(2015) Liwen Wu et al.   PHYSIOLOGY & BEHAVIOR

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR regulates brain morphogenesis by mediating GSK3 signaling

(2014) M. Ka et al.   DEVELOPMENT

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits

(2014) Giuseppe Gangarossa et al.   HIPPOCAMPUS

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures

(2014) Nesrin Bahçekapılı et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Protein Degradation and Quality Control in Cells from Laforin and Malin Knockout Mice

(2014) Punitee Garyali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations

(2014) Filippo Sean Giorgi et al.   JOURNAL OF NEURAL TRANSMISSION

Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits

(2014) Guomei Tang et al.   NEURON

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

(2014) Bożena Gabryel et al.   Pharmacological Reports

Epilepsy in Systemic Autoimmune Disorders

(2014) Ignacio Valencia   Seminars in Pediatric Neurology

Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease

(2014) Saida Ortolano et al.   Molecular Brain

mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis

(2013) Shireena A. Yasin et al.   ACTA NEUROPATHOLOGICA

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

Phospholipase D-mediated autophagic regulation is a potential target for cancer therapy

(2013) Y H Jang et al.   CELL DEATH AND DIFFERENTIATION

Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway

(2013) HIDEHIRO OKURA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Tuberous Sclerosis and Fulminant Lupus in a Young Woman

(2013) Namrata Singh et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

Oxidative stress in the pathology and treatment of systemic lupus erythematosus

(2013) Andras Perl   Nature Reviews Rheumatology

Electroconvulsive seizures enhance autophagy signaling in rat hippocampus

(2013) Hiroyuki Otabe et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Rac1 and Rac3 GTPases Control Synergistically the Development of Cortical and Hippocampal GABAergic Interneurons

(2012) Valentina Vaghi et al.   CEREBRAL CORTEX

Metabolic regulation of organelle homeostasis in lupus T cells

(2012) Tiffany N. Caza et al.   CLINICAL IMMUNOLOGY

Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy

(2012) Robin C. C. Ryther et al.   Current Neurology and Neuroscience Reports

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Pentylenetetrazole-induced seizures cause acute, but not chronic, mTOR pathway activation in rat

(2012) Bo Zhang et al.   EPILEPSIA

Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures

(2012) C. Fabrizi et al.   JOURNAL OF NEURAL TRANSMISSION

Neuronal Stimulation Induces Autophagy in Hippocampal Neurons That Is Involved in AMPA Receptor Degradation after Chemical Long-Term Depression

(2012) M. Shehata et al.   JOURNAL OF NEUROSCIENCE

Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

(2012) J. McMahon et al.   JOURNAL OF NEUROSCIENCE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway

(2012) Delia M. Talos et al.   PLoS One

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice

(2011) C. Nicole Sunnen et al.   EPILEPSIA

Dysfunctions in endosomal–lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease

(2011) Rajat Puri et al.   HUMAN MOLECULAR GENETICS

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2011) Olga Criado et al.   HUMAN MOLECULAR GENETICS

Impaired autophagy: a link between neurodegenerative diseases and progressive myoclonus epilepsies

(2011) Mira Polajnar et al.   TRENDS IN MOLECULAR MEDICINE

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Regulation of AMPA Receptor Trafficking and Function by Glycogen Synthase Kinase 3

(2010) Jing Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in acute brain injury: Feast, famine, or folly?

(2010) Craig M. Smith et al.   NEUROBIOLOGY OF DISEASE

The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

(2009) Mei Ding et al.   BIOESSAYS

The natural history of epilepsy in tuberous sclerosis complex

(2009) Catherine J. Chu-Shore et al.   EPILEPSIA

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

Autophagy promotes synapse development inDrosophila

(2009) Wei Shen et al.   JOURNAL OF CELL BIOLOGY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord

(2009) J. Calderó et al.   NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE