Deletion of mTOR in Reactive Astrocytes Suppresses Chronic Seizures in a Mouse Model of Temporal Lobe Epilepsy

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury

(2015) Yona Goldshmit et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

(2013) Kathleen Heng et al.   EPILEPSIA

Notch Signaling Activation Promotes Seizure Activity in Temporal Lobe Epilepsy

(2013) Longze Sha et al.   MOLECULAR NEUROBIOLOGY

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

(2013) Mauro Costa-Mattioli et al.   NATURE NEUROSCIENCE

Regulation of astrocyte glutamine synthetase in epilepsy

(2013) Tore Eid et al.   NEUROCHEMISTRY INTERNATIONAL

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

(2013) Sharon C Yates et al.   Acta Neuropathologica Communications

Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures

(2012) Linglin Chen et al.   EPILEPSIA

The mTOR pathway is activated in glial cells in mesial temporal sclerosis

(2012) Alexander A. Sosunov et al.   EPILEPSIA

Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination

(2012) Jaime Martínez-Villarreal et al.   GLIA

De novo somatic mutations in components of the PI3K-AKT3-mTOR pathway cause hemimegalencephaly

(2012) Jeong Ho Lee et al.   NATURE GENETICS

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

Frontier of Epilepsy Research - mTOR signaling pathway

(2011) Chang-Hoon Cho   EXPERIMENTAL AND MOLECULAR MEDICINE

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner

(2011) S. Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

(2010) Xiaofeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex

(2010) L.-H. Zeng et al.   HUMAN MOLECULAR GENETICS

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Loss of Tsc2 in radial glia models the brain pathology of tuberous sclerosis complex in the mouse

(2009) S. W. Way et al.   HUMAN MOLECULAR GENETICS

Epidermal-growth-factor-induced proliferation of astrocytes requires Egr transcription factors

(2009) S. I. Mayer et al.   JOURNAL OF CELL SCIENCE

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

(2009) S. Codeluppi et al.   JOURNAL OF NEUROSCIENCE

Development of Spontaneous Recurrent Seizures after Kainate-Induced Status Epilepticus

(2009) P. A. Williams et al.   JOURNAL OF NEUROSCIENCE

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1

(2008) Amanda L. Sheldon et al.   NEUROCHEMISTRY INTERNATIONAL

Degradation of Glial Glutamate Transporter mRNAs Is Selectively Blockedby Inhibition of Cellular Transcription

(2003) Olga A. Zelenaia et al.   JOURNAL OF NEUROCHEMISTRY