Oxidative stress in the pathology and treatment of systemic lupus erythematosus

PP2A Dephosphorylates Elf-1 and Determines the Expression of CD3  and FcR  in Human Systemic Lupus Erythematosus T Cells

(2014) Y.-T. Juang et al.   JOURNAL OF IMMUNOLOGY

Methylation Status of CpG Islands Flanking a cAMP Response Element Motif on the Protein Phosphatase 2Ac  Promoter Determines CREB Binding and Activity

(2014) K. Sunahori et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Target of Rapamycin Activation Triggers IL-4 Production and Necrotic Death of Double-Negative T Cells in Patients with Systemic Lupus Erythematosus

(2013) Z.-W. Lai et al.   JOURNAL OF IMMUNOLOGY

Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells

(2012) Gabriela J. Gorelik et al.   ARTHRITIS AND RHEUMATISM

Anti-tumor necrosis factor α treatment of interferon-α-induced murine lupus nephritis reduces the renal macrophage response but does not alter glomerular immune complex formation

(2012) Ramalingam Bethunaickan et al.   ARTHRITIS AND RHEUMATISM

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis

(2012) Xinli Shao et al.   ARTHRITIS AND RHEUMATISM

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

(2012) Hongwei Yao et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic regulation of organelle homeostasis in lupus T cells

(2012) Tiffany N. Caza et al.   CLINICAL IMMUNOLOGY

The origin and properties of extracellular DNA: From PAMP to DAMP

(2012) David S. Pisetsky   CLINICAL IMMUNOLOGY

Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations

(2012) R. Lee et al.   CURRENT MEDICINAL CHEMISTRY

Association between Serum Total Antioxidant Status and Coronary Microvascular Functions in Patients with SLE

(2012) Sema Yılmaz et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Decreased STAT5 phosphorylation and GATA-3 expression in NOX2-deficient T cells: Role in T helper development

(2012) Kristen E. Shatynski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Oxidative stress-responsive microRNA-320 regulates glycolysis in diverse biological systems

(2012) Huibin Tang et al.   FASEB JOURNAL

Regulation of innate immunity by NADPH oxidase

(2012) Brahm H. Segal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Physicochemical and immunological studies on 4-hydroxynonenal modified HSA: Implications of protein damage by lipid peroxidation products in the etiopathogenesis of SLE

(2012) Farzana Khatoon et al.   HUMAN IMMUNOLOGY

Oxidative Stress Promotes Hypertension and Albuminuria During the Autoimmune Disease Systemic Lupus Erythematosus

(2012) Keisa W. Mathis et al.   HYPERTENSION

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling

(2012) Mark J. Crabtree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S-adenosylmethionine (SAMe) therapy in liver disease: A review of current evidence and clinical utility

(2012) Quentin M. Anstee et al.   JOURNAL OF HEPATOLOGY

Murine Lupus Susceptibility Locus Sle1c2 Mediates CD4+ T Cell Activation and Maps to Estrogen-Related Receptor  

(2012) D. J. Perry et al.   JOURNAL OF IMMUNOLOGY

Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways

(2012) Samuel E. Vaughn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Accelerated atherosclerosis in patients with SLE—mechanisms and management

(2012) Brian J. Skaggs et al.   Nature Reviews Rheumatology

Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

(2012) M. V. Gerashchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Antroquinonol differentially modulates T cell activity and reduces interleukin-18 production, but enhances Nrf2 activation, in murine accelerated severe lupus nephritis

(2011) Pei-Yi Tsai et al.   ARTHRITIS AND RHEUMATISM

Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I

(2011) Yiannis Ioannou et al.   ARTHRITIS AND RHEUMATISM

The epigenetic effect of glucosamine and a nuclear factor-kappa B (NF-kB) inhibitor on primary human chondrocytes – Implications for osteoarthritis

(2011) Kei Imagawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autoantigenesis: the evolution of protein modifications in autoimmune disease

(2011) Hester A Doyle et al.   CURRENT OPINION IN IMMUNOLOGY

Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer

(2011) Alberto J. Montero et al.   DRUGS

Rapamycin-sensitive signals control TCR/CD28-drivenIfng,Il4andFoxp3transcription and promoter region methylation

(2011) Romana Tomasoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association between T lymphocyte sub-sets apoptosis and peripheral blood mononuclear cells oxidative stress in systemic lupus erythematosus

(2011) Dilip Shah et al.   FREE RADICAL RESEARCH

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post-translational modification of beta 2 glycoprotein I

(2011) F. H. PASSAM et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Targeting of B Cells for Rheumatic Autoimmune Diseases

(2011) P. Engel et al.   PHARMACOLOGICAL REVIEWS

Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase

(2011) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress, inflammation and carcinogenesis are controlled through the pentose phosphate pathway by transaldolase

(2011) Andras Perl et al.   TRENDS IN MOLECULAR MEDICINE

Antioxidant Intake and Risks of Rheumatoid Arthritis and Systemic Lupus Erythematosus in Women

(2010) K. H. Costenbader et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Naturally occurring free thiols within  2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells, and regulation of oxidative stress-induced cell injury

(2010) Y. Ioannou et al.   BLOOD

Malondialdehyde-modified low-density lipoproteins as biomarker for atherosclerosis

(2010) Margus Viigimaa et al.   BLOOD PRESSURE

The association between single-nucleotide polymorphisms of NCF2 and systemic lupus erythematosus in Chinese mainland population

(2010) Bo Yu et al.   CLINICAL RHEUMATOLOGY

Endogenous retroviral pathogenesis in lupus

(2010) Andras Perl et al.   CURRENT OPINION IN RHEUMATOLOGY

Identification of a Lipid Peroxidation Product as the Source of Oxidation-specific Epitopes Recognized by Anti-DNA Autoantibodies

(2010) Natsuki Otaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus

(2010) EJ Córdova et al.   LUPUS

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Oxidative Protein Folding in the Secretory Pathway and Redox Signaling Across Compartments and Cells

(2010) Éva Margittai et al.   TRAFFIC

Young Investigator Award Lecture of the APS Water and Electrolyte Homeostasis Section, 2008: The pathophysiology of hypertension in systemic lupus erythematosus

(2009) Michael J. Ryan   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Systems biology of lupus: Mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment

(2009) Andras Perl   AUTOIMMUNITY

AGE and their receptor RAGE in systemic autoimmune diseases: An inflammation propagating factor contributing to accelerated atherosclerosis

(2009) Hans L. A. Nienhuis et al.   AUTOIMMUNITY

Evidence of Autoimmune-Related Effects of Trichloroethylene Exposure from Studies in Mice and Humans

(2009) Glinda S. Cooper et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Pharmacotherapy of systemic lupus erythematosus

(2009) Lisa Francis et al.   EXPERT OPINION ON PHARMACOTHERAPY

Association of UCP2 −866 G/A polymorphism with chronic inflammatory diseases

(2009) X Yu et al.   GENES AND IMMUNITY

Activation of Mammalian Target of Rapamycin Controls the Loss of TCR  in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation

(2009) D. R. Fernandez et al.   JOURNAL OF IMMUNOLOGY

Antibodies to DNA: infection or genetics?

(2009) DS Pisetsky et al.   LUPUS

Endothelial nitric oxide synthase and nicotinamide adenosine dinucleotide phosphate oxidase p22phox gene (C242T) polymorphisms and systemic lupus erythematosus in a Chinese Population

(2009) F-Y. Tang et al.   LUPUS

Oxidative stress and homocysteine metabolism in patients with lupus nephritis

(2009) G. Moroni et al.   LUPUS

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosus

(2008) Tamara Vyshkina et al.   CLINICAL IMMUNOLOGY

Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients

(2008) A H Sawalha et al.   GENES AND IMMUNITY

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GSH and analogs in antiviral therapy

(2008) Alessandra Fraternale et al.   MOLECULAR ASPECTS OF MEDICINE