Review: Animal models of acquired epilepsy: insights into mechanisms of human epileptogenesis

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment

(2016) Henrik Klitgaard et al.   EPILEPSIA

Genotype and brain pathology phenotype in children with tuberous sclerosis complex

(2016) Iris E Overwater et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Models of cortical malformation—Chemical and physical

(2016) Heiko J. Luhmann   JOURNAL OF NEUROSCIENCE METHODS

In vivo models of cortical acquired epilepsy

(2016) Sylvain Chauvette et al.   JOURNAL OF NEUROSCIENCE METHODS

Which insights have we gained from the kindling and post-status epilepticus models?

(2016) Jan A. Gorter et al.   JOURNAL OF NEUROSCIENCE METHODS

Genetic animal models of malformations of cortical development and epilepsy

(2016) Michael Wong et al.   JOURNAL OF NEUROSCIENCE METHODS

Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder

(2016) A Y Lopez et al.   MOLECULAR PSYCHIATRY

Targeted in vivo genetic manipulation of the mouse or rat brain by in utero electroporation with a triple-electrode probe

(2016) Joanna Szczurkowska et al.   Nature Protocols

Low-grade epilepsy-associated neuroepithelial tumours — the 2016 WHO classification

(2016) Ingmar Blümcke et al.   Nature Reviews Neurology

Minute amounts of hamartin wildtype rescue the emergence of tuber-like lesions in conditional Tsc1 ablated mice

(2016) Barbara K. Robens et al.   NEUROBIOLOGY OF DISEASE

The Epidemiology of Global Epilepsy

(2016) Anuradha Singh et al.   NEUROLOGIC CLINICS

MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset

(2016) Christina Gross et al.   Cell Reports

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy

(2016) Gary P. Brennan et al.   Cold Spring Harbor Perspectives in Medicine

Etiology matters – Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy

(2016) Konrad J. Dębski et al.   Scientific Reports

Infections, inflammation and epilepsy

(2015) Annamaria Vezzani et al.   ACTA NEUROPATHOLOGICA

Somatic Mutations in theMTORgene cause focal cortical dysplasia type IIb

(2015) Mitsuko Nakashima et al.   ANNALS OF NEUROLOGY

Epileptogenic effects of NMDAR antibodies in a passive transfer mouse model

(2015) Sukhvir Wright et al.   BRAIN

The enigma of the latent period in the development of symptomatic acquired epilepsy — Traditional view versus new concepts

(2015) Wolfgang Löscher et al.   EPILEPSY & BEHAVIOR

Network pharmacology for antiepileptogenesis: Tolerability of multitargeted drug combinations in nonepileptic vs. post-status epilepticus mice

(2015) Rebecca Klee et al.   EPILEPSY RESEARCH

Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus

(2015) M. Royeck et al.   JOURNAL OF NEUROSCIENCE

Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy

(2015) Jae Seok Lim et al.   NATURE MEDICINE

The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy

(2015) Friederike Twele et al.   NEUROPHARMACOLOGY

Antibody-Mediated Autoimmune Encephalopathies and Immunotherapies

(2015) Matteo Gastaldi et al.   Neurotherapeutics

IL-1β, IL-6 and IL1Ra levels in temporal lobe epilepsy

(2015) Irem Fatma Uludag et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1

(2015) Karen M. J. van Loo et al.   Nature Communications

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

(2015) Michael R. Johnson et al.   Nature Communications

MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy – comparison with human epileptic samples

(2015) Paolo Roncon et al.   Scientific Reports

Epileptogenesis

(2015) Asla Pitkänen et al.   Cold Spring Harbor Perspectives in Medicine

Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

(2015) Mario Manto et al.   Frontiers in Behavioral Neuroscience

Autoimmune encephalopathies

(2014) Frank Leypoldt et al.   Annals of the New York Academy of Sciences

Zinc: An underappreciated modulatory factor of brain function

(2014) L. Marger et al.   BIOCHEMICAL PHARMACOLOGY

Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice

(2014) Jesús Planagumà et al.   BRAIN

Complement C5-deficient mice are protected from seizures in experimental cerebral malaria

(2014) Susan C. Buckingham et al.   EPILEPSIA

ILAE Official Report: A practical clinical definition of epilepsy

(2014) Robert S. Fisher et al.   EPILEPSIA

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

Epilepsy Related to Traumatic Brain Injury

(2014) Asla Pitkänen et al.   Neurotherapeutics

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

(2014) N. Lozovaya et al.   Nature Communications

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

(2014) Shawn McClelland et al.   eLife

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

(2013) Katja Kobow et al.   ACTA NEUROPATHOLOGICA

Hippocampal sclerosis after febrile status epilepticus: The FEBSTAT study

(2013) Darrell V. Lewis et al.   ANNALS OF NEUROLOGY

International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods

(2013) Ingmar Blümcke et al.   EPILEPSIA

Temporal lobe surgery in Germany from 1988 to 2008: diverse trends in etiological subgroups

(2013) C. Helmstaedter et al.   EUROPEAN JOURNAL OF NEUROLOGY

Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain

(2013) Young Se Kwon et al.   Journal of Neuroinflammation

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Alterations in miRNA Levels in the Dentate Gyrus in Epileptic Rats

(2013) Anna Maria Bot et al.   PLoS One

Increased Seizure Susceptibility in Mice 30 Days after Fluid Percussion Injury

(2013) Sanjib Mukherjee et al.   Frontiers in Neurology

Long-Term Epilepsy-Associated Tumors

(2012) Maria Thom et al.   BRAIN PATHOLOGY

Epileptic Encephalitis: The Role of the Innate and Adaptive Immune System

(2012) Jan Bauer et al.   BRAIN PATHOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy

(2012) Robin C. C. Ryther et al.   Current Neurology and Neuroscience Reports

Evidence-based review on the natural history of the epilepsies

(2012) Dieter Schmidt et al.   CURRENT OPINION IN NEUROLOGY

Epigenetics and epilepsy

(2012) Avtar Roopra et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats

(2012) Marta Rattka et al.   EPILEPSY RESEARCH

Experimental epilepsy affects Notch1 signalling and the stem cell pool in the dentate gyrus

(2012) Mirjam Sibbe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization

(2012) Manuela Mazzuferi et al.   EXPERIMENTAL NEUROLOGY

Transcriptional Regulation of T-type Calcium Channel CaV3.2

(2012) Karen M. J. van Loo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects

(2012) Eva M Jimenez-Mateos et al.   NATURE MEDICINE

Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury

(2012) Jeanne T Paz et al.   NATURE NEUROSCIENCE

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Defining “epileptogenesis” and identifying “antiepileptogenic targets” in animal models of acquired temporal lobe epilepsy is not as simple as it might seem

(2012) Robert S. Sloviter et al.   NEUROPHARMACOLOGY

Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy

(2012) Anna Sliwa et al.   NEUROSCIENCE LETTERS

Optogenetic and Potassium Channel Gene Therapy in a Rodent Model of Focal Neocortical Epilepsy

(2012) R. C. Wykes et al.   Science Translational Medicine

Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy

(2011) Shawn McClelland et al.   ANNALS OF NEUROLOGY

Towards an integrated view of HCN channel role in epilepsy

(2011) Yoav Noam et al.   CURRENT OPINION IN NEUROBIOLOGY

Neurotropic viral infections leading to epilepsy: focus on Theiler’s murine encephalomyelitis virus

(2011) Jane E Libbey et al.   Future Virology

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

(2011) Jan Gronych et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

(2011) David M. Feliciano et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Rapid Loss of Dendritic HCN Channel Expression in Hippocampal Pyramidal Neurons following Status Epilepticus

(2011) S. Jung et al.   JOURNAL OF NEUROSCIENCE

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Development of Post-Traumatic Epilepsy after Controlled Cortical Impact and Lateral Fluid-Percussion-Induced Brain Injury in the Mouse

(2011) Tamuna Bolkvadze et al.   JOURNAL OF NEUROTRAUMA

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

The time course of acquired epilepsy: Implications for therapeutic intervention to suppress epileptogenesis

(2011) F. Edward Dudek et al.   NEUROSCIENCE LETTERS

In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction

(2011) Mario Manto et al.   Orphanet Journal of Rare Diseases

mTOR: A pathogenic signaling pathway in developmental brain malformations

(2011) Peter B. Crino   TRENDS IN MOLECULAR MEDICINE

Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders

(2010) Silvio R. Bareggi et al.   CNS Neuroscience & Therapeutics

The clinicopathologic spectrum of focal cortical dysplasias: A consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission1

(2010) Ingmar Blümcke et al.   EPILEPSIA

Afferent facilitation of corticomotor responses is increased by IgGs of patients with NMDA-receptor antibodies

(2010) Mario Manto et al.   JOURNAL OF NEUROLOGY

Development of Postinfection Epilepsy After Theiler's Virus Infection of C57BL/6 Mice

(2010) Kerry-Ann A. Stewart et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Role for Complement in the Development of Seizures following Acute Viral Infection

(2010) J. E. Libbey et al.   JOURNAL OF VIROLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Mutations affecting GABAergic signaling in seizures and epilepsy

(2010) Aristea S. Galanopoulou   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research

(2010) W. Loscher et al.   PHARMACOLOGICAL REVIEWS

Epilepsy and Cognitive Impairments in Alzheimer Disease

(2009) Jorge J. Palop   ARCHIVES OF NEUROLOGY

Selective changes in GABAA receptor subtypes in white matter neurons of patients with focal epilepsy

(2009) F. Loup et al.   BRAIN

The multifaceted role of inhibition in epilepsy: seizure-genesis through excessive GABAergic inhibition in autosomal dominant nocturnal frontal lobe epilepsy

(2009) Edward O Mann et al.   CURRENT OPINION IN NEUROLOGY

Epilepsy after head injury: An overview

(2009) Daniel H. Lowenstein   EPILEPSIA

Neuronal plasticity in animal models and the epileptic human hippocampus

(2009) Gunther Sperk et al.   EPILEPSIA

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

A potential model of pediatric posttraumatic epilepsy

(2009) K.D. Statler et al.   EPILEPSY RESEARCH

Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

(2009) Katja Kobow et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Temporal Lobe Sclerosis Associated With Hippocampal Sclerosis in Temporal Lobe Epilepsy: Neuropathological Features

(2009) Maria Thom et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Changes in Calcium-Binding Protein Expression in Human Cortical Contusion Tissue

(2009) Efraín Buriticá et al.   JOURNAL OF NEUROTRAUMA

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Alteration of epileptogenesis genes

(2009) Amy R. Brooks-Kayal et al.   Neurotherapeutics

Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease

(2009) J. BRIAN de SOUZA et al.   PARASITOLOGY

Loss of GABAergic neurons in the subiculum and its functional implications in temporal lobe epilepsy

(2008) A. Knopp et al.   BRAIN

Seizures following picornavirus infection

(2008) Jane E. Libbey et al.   EPILEPSIA

Transcriptional Upregulation of Cav3.2 Mediates Epileptogenesis in the Pilocarpine Model of Epilepsy

(2008) A. J. Becker et al.   JOURNAL OF NEUROSCIENCE

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE