Proteomic Analysis After Status Epilepticus Identifies UCHL1 as Protective Against Hippocampal Injury

Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury

(2017) Tobias Engel et al.   Molecular Neurodegeneration

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Seizures Are Regulated by Ubiquitin-specific Peptidase 9 X-linked (USP9X), a De-Ubiquitinase

(2015) Lily Paemka et al.   PLoS Genetics

Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning

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Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo

(2014) Mingming Zhang et al.   Scientific Reports

Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system

(2014) Josée Coulombe et al.   Frontiers in Aging Neuroscience

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

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Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86

(2013) Mehmet Canpolat et al.   CHILDS NERVOUS SYSTEM

Disruption of Arp2/3 Results in Asymmetric Structural Plasticity of Dendritic Spines and Progressive Synaptic and Behavioral Abnormalities

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Ubiquitin Hydrolase UCH-L1 Destabilizes mTOR Complex 1 by Antagonizing DDB1-CUL4-Mediated Ubiquitination of Raptor

(2013) Sajjad Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

(2013) Amy L. Brewster et al.   PLoS One

Constitutive Endocytosis and Turnover of the Neuronal Glycine Transporter GlyT2 Is Dependent on Ubiquitination of a C-Terminal Lysine Cluster

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Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

(2013) Kaya Bilguvar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Prevents Seizures After Depletion of STRADA in a Rare Neurodevelopmental Disorder

(2013) W. E. Parker et al.   Science Translational Medicine

Ubiquitin Carboxy-Terminal Hydrolase L1 (UCH-L1) is increased in cerebrospinal fluid and plasma of patients after epileptic seizure

(2012) Stefania Mondello et al.   BMC Neurology

Finding a better drug for epilepsy: Preclinical screening strategies and experimental trial design

(2012) Michele Simonato et al.   EPILEPSIA

Cerebrospinal fluid ubiquitin C-terminal hydrolase as a novel marker of neuronal damage after epileptic seizure

(2012) Yajun Li et al.   EPILEPSY RESEARCH

Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death

(2012) Ross C. McKiernan et al.   EXPERIMENTAL NEUROLOGY

UCHL1 regulates ubiquitination and recycling of the neural cell adhesion molecule NCAM

(2012) Hilke Wobst et al.   FEBS Journal

Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination

(2012) Jaime Martínez-Villarreal et al.   GLIA

Differential DNA Methylation Patterns Define Status Epilepticus and Epileptic Tolerance

(2012) S. F. C. Miller-Delaney et al.   JOURNAL OF NEUROSCIENCE

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat

(2012) Claudia Carrieri et al.   NATURE

Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy

(2012) Anna E. Cartier et al.   PLoS One

miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132

(2011) Eva M. Jimenez-Mateos et al.   AMERICAN JOURNAL OF PATHOLOGY

Kainate Promotes Alterations in Neuronal RNA Splicing Machinery

(2011) Michael Rohe et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity

(2011) Angelisa Frasca et al.   NEUROBIOLOGY OF DISEASE

Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword?

(2010) Ling-Hui Zeng et al.   CELL CYCLE

Comparison of protein precipitation methods for various rat brain structures prior to proteomic analysis

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Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation

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A Role for the Ubiquitin-Proteasome System in Activity-Dependent Presynaptic Silencing

(2010) X. Jiang et al.   JOURNAL OF NEUROSCIENCE

Deletion of puma protects hippocampal neurons in a model of severe status epilepticus

(2010) T. Engel et al.   NEUROSCIENCE

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation

(2010) Daniele Merico et al.   PLoS One

Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance

(2010) M. Stapels et al.   Science Signaling

Antiepileptic drug therapy the story so far

(2010) Martin J. Brodie   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies

(2009) Michael Wong   EPILEPSIA

Hippocampal damage after intra-amygdala kainic acid-induced status epilepticus and seizure preconditioning-mediated neuroprotection in SJL mice

(2009) Katsuhiro Tanaka et al.   EPILEPSY RESEARCH

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

(2009) Guo-Zhong Li et al.   PROTEOMICS

Effects of UCH-L1 on α-synuclein over-expression mouse model of Parkinson’s disease

(2008) Toru Yasuda et al.   JOURNAL OF NEUROCHEMISTRY

Ubiquitin Proteasome-Mediated Synaptic Reorganization: A Novel Mechanism Underlying Rapid Ischemic Tolerance

(2008) R. Meller et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor

(2008) Yu-Yan Tan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity

(2008) B.J. Walters et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal transcriptome after status epilepticus in mice rendered seizure damage-tolerant by epileptic preconditioning features suppressed calcium and neuronal excitability pathways

(2008) Eva M. Jimenez-Mateos et al.   NEUROBIOLOGY OF DISEASE

Comparative proteomics and correlated signaling network of rat hippocampus in the pilocarpine model of temporal lobe epilepsy

(2008) Xin-Yu Liu et al.   PROTEOMICS