Cell Clearing Systems Bridging Neuro-Immunity and Synaptic Plasticity

The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy

(2019) Katarzyna Zientara-Rytter et al.   Cells

Emerging Concepts and Functions of Autophagy as a Regulator of Synaptic Components and Plasticity

(2019) YongTian Liang   Cells

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future

(2018) Benjamin A. Plog et al.   Annual Review of Pathology-Mechanisms of Disease

Mood-stabilizing effects of rapamycin and its analog temsirolimus

(2018) Nirit Z. Kara et al.   BEHAVIOURAL PHARMACOLOGY

CD8 + T cells are essential for the effects of enriched environment on hippocampus-dependent behavior, hippocampal neurogenesis and synaptic plasticity

(2018) Hadi Zarif et al.   BRAIN BEHAVIOR AND IMMUNITY

A Focus on the Beneficial Effects of Alpha Synuclein and a Re-Appraisal of Synucleinopathies

(2018) Larisa Ryskalin et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs

(2018) Thea P. Lillethorup et al.   EXPERIMENTAL NEUROLOGY

The role of immune cells in brain development and neurodevelopmental diseases

(2018) Shogo Tanabe et al.   INTERNATIONAL IMMUNOLOGY

Dopamine Receptor Subtypes Differentially Regulate Autophagy

(2018) Dongmei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy-independent increase of ATG5 expression in T cells of multiple sclerosis patients

(2018) Verica Paunovic et al.   JOURNAL OF NEUROIMMUNOLOGY

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

Interaction between blood-brain barrier and glymphatic system in solute clearance

(2018) I.C.M. Verheggen et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

mTOR signaling in the nucleus accumbens mediates behavioral sensitization to methamphetamine

(2018) Shin-Han Huang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells

(2018) Xin He et al.   TOXICOLOGY LETTERS

Regulation and Roles of Autophagy at Synapses

(2018) Vassiliki Nikoletopoulou et al.   TRENDS IN CELL BIOLOGY

Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles

(2018) Corinna Wentzel et al.   Nature Communications

A common mechanism of proteasome impairment by neurodegenerative disease-associated oligomers

(2018) Tiffany A. Thibaudeau et al.   Nature Communications

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

(2018) Jun Wang et al.   Nature Communications

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

(2018) Shigeto Sato et al.   Scientific Reports

Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease

(2018) Débora Masini et al.   Frontiers in Neurology

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

Induction of the Immunoproteasome Subunit Lmp7 Links Proteostasis and Immunity in α-Synuclein Aggregation Disorders

(2018) Scott Ugras et al.   EBioMedicine

To save or degrade: balancing proteasome homeostasis to maximize cell survival

(2018) Richard S. Marshall et al.   Autophagy

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

(2018) Larisa Ryskalin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ambiguous Effects of Autophagy Activation Following Hypoperfusion/Ischemia

(2018) Michela Ferrucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress

(2018) Fiona Limanaqi et al.   Oxidative Medicine and Cellular Longevity

Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy

(2018) Enric Mocholi et al.   Cell Reports

Interdependency Between Autophagy and Synaptic Vesicle Trafficking: Implications for Dopamine Release

(2018) Fiona Limanaqi et al.   Frontiers in Molecular Neuroscience

Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases

(2018) Florent Arbogast et al.   Frontiers in Immunology

Dopaminergic neurons show increased low-molecular-mass protein 7 activity induced by 6-hydroxydopamine in vitro and in vivo

(2018) Ming-Shu Mo et al.   Translational Neurodegeneration

Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis

(2018) Ling Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mTOR Modulates Methamphetamine-Induced Toxicity through Cell Clearing Systems

(2018) Gloria Lazzeri et al.   Oxidative Medicine and Cellular Longevity

Tissue-resident memory T cells populate the human brain

(2018) Joost Smolders et al.   Nature Communications

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

(2018) Meng-meng Jin et al.   Frontiers in Aging Neuroscience

Resveratrol as a new inhibitor of immunoproteasome prevents PTEN degradation and attenuates cardiac hypertrophy after pressure overload

(2018) Chen Chen et al.   Redox Biology

Inhibition of Autophagy in Microglia Alters Depressive-Like Behavior via BDNF Pathway in Postpartum Depression

(2018) Xiaoning Tan et al.   Frontiers in Psychiatry

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4

(2017) Jennifer C. Peeler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy in the presynaptic compartment in health and disease

(2017) Vinoy Vijayan et al.   JOURNAL OF CELL BIOLOGY

Parkin promotes proteasomal degradation of misregulated BAX

(2017) Zeynep Cakir et al.   JOURNAL OF CELL SCIENCE

The Macroautophagy Machinery in Endo- and Exocytosis

(2017) Christian Münz   JOURNAL OF MOLECULAR BIOLOGY

Dopamine, T cells and multiple sclerosis (MS)

(2017) Mia Levite et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation contributes to autophagy flux blockage in the neurons of rostral ventrolateral medulla in stress-induced hypertension rats

(2017) Dongshu Du et al.   Journal of Neuroinflammation

Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations

(2017) Ke Li et al.   MOLECULAR NEUROBIOLOGY

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

(2017) Annika Sommer et al.   Molecular Neurodegeneration

Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation

(2017) Y Akwa et al.   MOLECULAR PSYCHIATRY

Proteolysis, synaptic plasticity and memory

(2017) Ashok N. Hegde   NEUROBIOLOGY OF LEARNING AND MEMORY

Postnatal Proteasome Inhibition Promotes Amyloid-β Aggregation in Hippocampus and Impairs Spatial Learning in Adult Mice

(2017) Aditya Sunkaria et al.   NEUROSCIENCE

Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

(2017) Rosario Moratalla et al.   PROGRESS IN NEUROBIOLOGY

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway

(2017) Aslihan Ugun-Klusek et al.   Cell Death & Disease

The role of the immunoproteasome in interferon-γ-mediated microglial activation

(2017) Kasey E. Moritz et al.   Scientific Reports

Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease

(2017) Jenny-Ann Phan et al.   Scientific Reports

The Proteasome Inhibition Model of Parkinson’s Disease

(2017) Eduard Bentea et al.   Journal of Parkinsons Disease

mTOR-Dependent Cell Proliferation in the Brain

(2017) Larisa Ryskalin et al.   Biomed Research International

Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion

(2017) Donghyuk Shin et al.   eLife

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

ATGs help MHC class II, but inhibit MHC class I antigen presentation

(2016) Monica Loi et al.   Autophagy

The life cycle of the 26S proteasome: from birth, through regulation and function and onto its death

(2016) Ido Livneh et al.   CELL RESEARCH

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

(2016) Wei Jing Liu et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The Immunoproteasome in oxidative stress, aging, and disease

(2016) Helen K. Johnston-Carey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The effects of proteasomal inhibition on synaptic proteostasis

(2016) Vicky Hakim et al.   EMBO JOURNAL

mTOR inhibitor reverses autistic-like social deficit behaviours in adult rats with both Tsc2 haploinsufficiency and developmental status epilepticus

(2016) Miriam Schneider et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The impact of autophagy on peripheral synapses in health and disease

(2016) Rudiger Rudolf   Frontiers in Bioscience-Landmark

Autophagy proteins in antigen processing for presentation on MHC molecules

(2016) Christian Münz   IMMUNOLOGICAL REVIEWS

ULK1 cycling: The ups and downs of the autophagy response

(2016) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

Regulation of Autophagy By Signaling Through the Atg1/ULK1 Complex

(2016) Daniel Papinski et al.   JOURNAL OF MOLECULAR BIOLOGY

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development

(2016) J. van Scheppingen et al.   Journal of Neuroinflammation

Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway

(2016) Patricia Sheehan et al.   JOURNAL OF NEUROSCIENCE

Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B

(2016) D. Villarroel-Campos et al.   JOURNAL OF NEUROSCIENCE

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

(2016) Young Sung Yun et al.   MOLECULAR CELL

Neuroprotection Through Rapamycin-Induced Activation of Autophagy and PI3K/Akt1/mTOR/CREB Signaling Against Amyloid-β-Induced Oxidative Stress, Synaptic/Neurotransmission Dysfunction, and Neurodegeneration in Adult Rats

(2016) Abhishek Kumar Singh et al.   MOLECULAR NEUROBIOLOGY

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Early synaptic dysfunction in Parkinson's disease: Insights from animal models

(2016) Tommaso Schirinzi et al.   MOVEMENT DISORDERS

Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats

(2016) J. Konieczny et al.   NEUROSCIENCE

The role of autophagy in modulation of neuroinflammation in microglia

(2016) P. Su et al.   NEUROSCIENCE

Impairment of the autophagic flux in astrocytes intoxicated by trimethyltin

(2016) Cinzia Fabrizi et al.   NEUROTOXICOLOGY

p62- and ubiquitin-dependent stress-induced autophagy of the mammalian 26S proteasome

(2016) Victoria Cohen-Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways

(2016) Irina N. Krasnova et al.   PSYCHOPHARMACOLOGY

Neurological Disease as a Failure of Brain–Immune Crosstalk: The Multiple Faces of Neuroinflammation

(2016) Michal Schwartz et al.   TRENDS IN IMMUNOLOGY

The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions

(2016) Paola Lenzi et al.   Frontiers in Neuroanatomy

p62 at the crossroad of the ubiquitin-proteasome system and autophagy

(2016) Victoria Cohen-Kaplan et al.   Oncotarget

Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain

(2016) Maciej J. Lazarczyk et al.   Scientific Reports

Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8 + T Cell Responses

(2016) Monica Loi et al.   Cell Reports

Eat or be eaten: The autophagic plight of inactive 26S proteasomes

(2015) Richard S Marshall et al.   Autophagy

KEAP1–NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity

(2015) Matthew Dodson et al.   BIOCHEMICAL JOURNAL

Brain diseases and tumorigenesis: The good and bad cops of pentraxin3

(2015) Francesco Fornai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mammalian target of rapamycin modulates the immunoproteasome system in the heart

(2015) Hong-Mei Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Induction of autophagy by the MG-132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF-7 cells

(2015) WENHUA BAO et al.   Molecular Medicine Reports

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

D1 dopamine receptor stimulation impairs striatal proteasome activity in Parkinsonism through 26S proteasome disassembly

(2015) Pedro Barroso-Chinea et al.   NEUROBIOLOGY OF DISEASE

mTOR inhibition activates overall protein degradation by the ubiquitin proteasome system as well as by autophagy

(2015) Jinghui Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Mechanisms of CNS Immune Privilege

(2015) Antoine Louveau et al.   TRENDS IN IMMUNOLOGY

Autophagy in synaptic development, function, and pathology

(2015) Dan-Na Shen et al.   Neuroscience Bulletin

Trafficking of lymphocytes into the CNS

(2015) Nicholas Schwab et al.   Oncotarget

Neuroinflammation and J2 prostaglandins: linking impairment of the ubiquitin-proteasome pathway and mitochondria to neurodegeneration

(2015) Maria E. Figueiredo-Pereira et al.   Frontiers in Molecular Neuroscience

Endogenous Antigen Presentation of MHC Class II Epitopes through Non-Autophagic Pathways

(2015) Carol S. K. Leung   Frontiers in Immunology

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Ubiquitin-mediated NFκB degradation pathway

(2014) Huimin Xu et al.   Cellular & Molecular Immunology

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

(2014) Michael Basler et al.   EMBO Molecular Medicine

Selective increase ofin vivofiring frequencies in DA SN neurons after proteasome inhibition in the ventral midbrain

(2014) Mahalakshmi Subramaniam et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function

(2014) M. G. Otero et al.   JOURNAL OF CELL SCIENCE

New Function of Type I IFN: Induction of Autophagy

(2014) Hana Schmeisser et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The neurotransmitter glutamate and human T cells: glutamate receptors and glutamate-induced direct and potent effects on normal human T cells, cancerous human leukemia and lymphoma T cells, and autoimmune human T cells

(2014) Yonatan Ganor et al.   JOURNAL OF NEURAL TRANSMISSION

The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations

(2014) Filippo Sean Giorgi et al.   JOURNAL OF NEURAL TRANSMISSION

Proteasome Modulates Positive and Negative Translational Regulators in Long-Term Synaptic Plasticity

(2014) C. Dong et al.   JOURNAL OF NEUROSCIENCE

Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein

(2014) DANMEI LAN et al.   Molecular Medicine Reports

Functional Deficiency of MHC Class I Enhances LTP and Abolishes LTD in the Nucleus Accumbens of Mice

(2014) Mitsuhiro Edamura et al.   PLoS One

Does autophagy work in synaptic plasticity and memory?

(2014) Mohammad Shehata et al.   REVIEWS IN THE NEUROSCIENCES

TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

(2014) A Pla et al.   Cell Death & Disease

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson’s and other brain diseases

(2014) Carolina Cebrián et al.   Frontiers in Neuroanatomy

The ubiquitin proteasome system in glia and its role in neurodegenerative diseases

(2014) Anne H. P. Jansen et al.   Frontiers in Molecular Neuroscience

Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein

(2013) Fang Yang et al.   ACTA PHARMACOLOGICA SINICA

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins

(2013) James A. Nathan et al.   CELL

Neurotransmitters and Microglial-Mediated Neuroinflammation

(2013) Moonhee Lee   CURRENT PROTEIN & PEPTIDE SCIENCE

Efficiently stimulated adult microglia cross-prime naive CD8+T cells injected in the brain

(2013) Ulrich Jarry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dopamine Receptor D3 Expressed on CD4+ T Cells Favors Neurodegeneration of Dopaminergic Neurons during Parkinson's Disease

(2013) H. Gonzalez et al.   JOURNAL OF IMMUNOLOGY

Prokaryotic Proteasomes: Nanocompartments of Degradation

(2013) Matthew A. Humbard et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Minireview: Ubiquitination-regulated G Protein-Coupled Receptor Signaling and Trafficking

(2013) Verónica Alonso et al.   MOLECULAR ENDOCRINOLOGY

Dysfunction of the Ubiquitin Proteasome and Ubiquitin-Like Systems in Schizophrenia

(2013) María D Rubio et al.   NEUROPSYCHOPHARMACOLOGY

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

Macroautophagy can press a brake on presynaptic neurotransmission

(2012) Ciara A. Torres et al.   Autophagy

Excitotoxic stimulation downregulates the ubiquitin–proteasome system through activation of NMDA receptors in cultured hippocampal neurons

(2012) Margarida V. Caldeira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Autophagy mediates transporter associated with antigen processing-independent presentation of viral epitopes through MHC class I pathway

(2012) S.-K. Tey et al.   BLOOD

Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity

(2012) Eva M. Huber et al.   CELL

Autophagy in regulation of Toll-like receptor signaling

(2012) Takeshi Into et al.   CELLULAR SIGNALLING

Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme

(2012) Elke Krüger et al.   CURRENT OPINION IN IMMUNOLOGY

The immunoproteasome in antigen processing and other immunological functions

(2012) Michael Basler et al.   CURRENT OPINION IN IMMUNOLOGY

CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s Disease

(2012) Jessica A. Hutter Saunders et al.   Journal of Neuroimmune Pharmacology

L-DOPA Impairs Proteasome Activity in Parkinsonism through D1 Dopamine Receptor

(2012) A. Berthet et al.   JOURNAL OF NEUROSCIENCE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Methamphetamine-induced neurotoxicity linked to ubiquitin-proteasome system dysfunction and autophagy-related changes that can be modulated by protein kinase C delta in dopaminergic neuronal cells

(2012) M. Lin et al.   NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The Dopaminergic System in Peripheral Blood Lymphocytes: From Physiology to Pharmacology and Potential Applications to Neuropsychiatric Disorders

(2011) Clelia Pellicano et al.   Current Neuropharmacology

Protein Aggregates Are Recruited to Aggresome by Histone Deacetylase 6 via Unanchored Ubiquitin C Termini

(2011) Hui Ouyang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Critical Role of Antigen-Presentation-Induced Cytokine Crosstalk in the Central Nervous System in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2011) Rebecca A. Sosa et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Decreased activity of the 20S proteasome in the brain white matter and gray matter of patients with multiple sclerosis

(2011) Jianzheng Zheng et al.   JOURNAL OF NEUROCHEMISTRY

In vivo imaging of lymphocytes in the CNS reveals different behaviour of naïve T cells in health and autoimmunity

(2011) Josephine Herz et al.   Journal of Neuroinflammation

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

(2011) Maria Teresa Ferretti et al.   NEUROBIOLOGY OF AGING

Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults

(2011) Joshua Hogins et al.   NEUROBIOLOGY OF DISEASE

Deconstruction for Reconstruction: The Role of Proteolysis in Neural Plasticity and Disease

(2011) Baris Bingol et al.   NEURON

Classic Major Histocompatibility Complex Class I Molecules: New Actors at the Neuromuscular Junction

(2011) Staffan Cullheim et al.   NEUROSCIENTIST

Postnatal Proteasome Inhibition Induces Neurodegeneration and Cognitive Deficiencies in Adult Mice: A New Model of Neurodevelopment Syndrome

(2011) Rocío Romero-Granados et al.   PLoS One

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

(2010) Lih-Shen Chin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of antigen presenting cells in multiple sclerosis

(2010) Emily M.L. Chastain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Immunoproteasomes Preserve Protein Homeostasis upon Interferon-Induced Oxidative Stress

(2010) Ulrike Seifert et al.   CELL

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

Autophagy, inflammation and neurodegenerative disease

(2010) Mehrdad Alirezaei et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Methamphetamine oxidatively damages parkin and decreases the activity of 26S proteasome in vivo

(2010) Anna Moszczynska et al.   JOURNAL OF NEUROCHEMISTRY

Ubiquitination Acutely Regulates Presynaptic Neurotransmitter Release in Mammalian Neurons

(2010) G. V. Rinetti et al.   JOURNAL OF NEUROSCIENCE

Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations

(2010) Beilei Lei et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The ubiquitin-proteasome pathway and synaptic plasticity

(2010) A. N. Hegde   LEARNING & MEMORY

Protective autoimmunity functions by intracranial immunosurveillance to support the mind: The missing link between health and disease

(2010) M Schwartz et al.   MOLECULAR PSYCHIATRY

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases

(2009) Mei Ding et al.   BIOESSAYS

The immunoregulatory role of dopamine: An update

(2009) Chandrani Sarkar et al.   BRAIN BEHAVIOR AND IMMUNITY

Methamphetamine toxicity and messengers of death

(2009) Irina N. Krasnova et al.   BRAIN RESEARCH REVIEWS

The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis

(2009) D Centonze et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Immune and Nervous Systems: More Than Just a Superficial Similarity?

(2009) Dimitris Kioussis et al.   IMMUNITY

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells

(2009) K Zhu et al.   ONCOGENE

Does autophagy worsen or improve the survival of dopaminergic neurons?

(2009) Livia Pasquali et al.   PARKINSONISM & RELATED DISORDERS

Neuronal regulation of immune responses in the central nervous system

(2009) Li Tian et al.   TRENDS IN IMMUNOLOGY

Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system

(2008) Shin-Young Na et al.   BRAIN

Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors

(2008) Mia Levite   CURRENT OPINION IN PHARMACOLOGY

Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation

(2008) Nicolas Fissolo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

BTB Protein KLHL12 Targets the Dopamine D4 Receptor for Ubiquitination by a Cul3-based E3 Ligase

(2008) Pieter Rondou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice

(2008) Jianjun Wang et al.   JOURNAL OF CELL BIOLOGY

Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

(2008) Roberta Castino et al.   JOURNAL OF NEUROCHEMISTRY

A Single Mutation at Lysine 241 Alters Expression and Trafficking of the D2Dopamine Receptor

(2008) Ok-Jin Kim   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Microglial responses to dopamine in a cell culture model of Parkinson's disease

(2008) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Neuro-immune crosstalk in CNS diseases

(2008) M. Kerschensteiner et al.   NEUROSCIENCE

Alpha-synuclein and autophagy as common steps in neurodegeneration

(2008) Michela Ferrucci et al.   PARKINSONISM & RELATED DISORDERS

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration

(2008) Mehrdad Alirezaei et al.   PLoS One