Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

(2016) Antonio Carlos Pinheiro de Oliveira et al.   Journal of Neuroinflammation

Neuroprotective effects of the anticancer drug NVP-BEZ235 (dactolisib) on amyloid-β 1–42 induced neurotoxicity and memory impairment

(2016) Paula Maria Quaglio Bellozi et al.   Scientific Reports

Preventive Effects of Rapamycin on Inflammation and Capillary Degeneration in a Rat Model of NMDA-Induced Retinal Injury

(2015) Yuto Aoki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy

(2015) Robert Siman et al.   PLoS One

Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release

(2014) Emilio Russo et al.   BRAIN BEHAVIOR AND IMMUNITY

Rapamycin preventsN-methyl-D-aspartate-induced retinal damage through an ERK-dependent mechanism in rats

(2014) Atsuko Ichikawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Improvement of Mitochondrial Function by Paliperidone Attenuates Quinolinic Acid-Induced Behavioural and Neurochemical Alterations in Rats: Implications in Huntington’s Disease

(2014) Jitendriya Mishra et al.   NEUROTOXICITY RESEARCH

Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells

(2013) Hye-Eun Han et al.   Biomolecules & Therapeutics

Excitotoxic glutamate insults block autophagic flux in hippocampal neurons

(2013) Jacqueline R. Kulbe et al.   BRAIN RESEARCH

mTOR signaling for biological control and cancer

(2013) Anya Alayev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Rapamycin Attenuates the Development of Posttraumatic Epilepsy in a Mouse Model of Traumatic Brain Injury

(2013) Dongjun Guo et al.   PLoS One

Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures

(2012) Linglin Chen et al.   EPILEPSIA

mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis

(2012) Cinzia Dello Russo et al.   GLIA

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease

(2012) Gang Wang et al.   PROGRESS IN NEUROBIOLOGY

Targeting mTOR with rapamycin: One dose does not fit all

(2011) David A. Foster et al.   CELL CYCLE

Rapamycin Promotes Autophagy and Reduces Neural Tissue Damage and Locomotor Impairment after Spinal Cord Injury in Mice

(2011) Akira Sekiguchi et al.   JOURNAL OF NEUROTRAUMA

Calcium Mediates Glomerular Filtration through Calcineurin and mTORC2/Akt Signaling

(2011) J. Vassiliadis et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Neurodegenerative processes in Huntington's disease

(2011) D Bano et al.   Cell Death & Disease

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

(2010) Xiaofeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats

(2010) Harikesh Kalonia et al.   BRAIN RESEARCH

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Intrastriatal lipopolysaccharide injection induces parkinsonism in C57/B6 mice

(2009) Randy L. Hunter et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reversal of learning deficits in a Tsc2 +/− mouse model of tuberous sclerosis

(2008) Dan Ehninger et al.   NATURE MEDICINE