Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits

T-type calcium channel Cav3.2 deficient mice show elevated anxiety, impaired memory and reduced sensitivity to psychostimulants

(2014) Giuseppe Gangarossa et al.   Frontiers in Behavioral Neuroscience

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

The role of dopamine signaling in epileptogenesis

(2013) Yuri Bozzi et al.   Frontiers in Cellular Neuroscience

Combinatorial topography and cell-type specific regulation of the ERK pathway by dopaminergic agonists in the mouse striatum

(2012) Giuseppe Gangarossa et al.   Brain Structure & Function

Mammalian Target of Rapamycin (mTOR) Inhibition: Potential for Antiseizure, Antiepileptogenic, and Epileptostatic Therapy

(2012) Robin C. C. Ryther et al.   Current Neurology and Neuroscience Reports

Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus

(2012) Giuseppe Gangarossa et al.   HIPPOCAMPUS

Excessive Activation of mTOR in Postnatally Generated Granule Cells Is Sufficient to Cause Epilepsy

(2012) Raymund Y.K. Pun et al.   NEURON

Regulation of the ERK pathway in the dentate gyrus by in vivo dopamine D1 receptor stimulation requires glutamatergic transmission

(2012) Giuseppe Gangarossa et al.   NEUROPHARMACOLOGY

Frontier of Epilepsy Research - mTOR signaling pathway

(2011) Chang-Hoon Cho   EXPERIMENTAL AND MOLECULAR MEDICINE

IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes

(2011) C. Gao et al.   JOURNAL OF NEUROSCIENCE

Haloperidol Regulates the State of Phosphorylation of Ribosomal Protein S6 via Activation of PKA and Phosphorylation of DARPP-32

(2011) Emmanuel Valjent et al.   NEUROPSYCHOPHARMACOLOGY

Convulsant Doses of a Dopamine D1 Receptor Agonist Result in Erk-Dependent Increases in Zif268 and Arc/Arg3.1 Expression in Mouse Dentate Gyrus

(2011) Giuseppe Gangarossa et al.   PLoS One

Cell Signaling Underlying Epileptic Behavior

(2011) Yuri Bozzi et al.   Frontiers in Behavioral Neuroscience

Associative Learning and CA3-CA1 Synaptic Plasticity Are Impaired in D1R Null, Drd1a-/- Mice and in Hippocampal siRNA Silenced Drd1a Mice

(2010) O. Ortiz et al.   JOURNAL OF NEUROSCIENCE

Dopamine and Memory: Modulation of the Persistence of Memory for Novel Hippocampal NMDA Receptor-Dependent Paired Associates

(2010) I. Bethus et al.   JOURNAL OF NEUROSCIENCE

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Dopamine and adaptive memory

(2010) Daphna Shohamy et al.   TRENDS IN COGNITIVE SCIENCES

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic β-Cells

(2009) Claire E.J. Moore et al.   JOURNAL OF MOLECULAR BIOLOGY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Effect of various antiepileptic drugs in a pentylenetetrazol-induced seizure model in mice

(2009) K.K. Akula et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Dopamine and epilepsy: Hints of complex subcortical roles

(2008) S. R. Haut et al.   NEUROLOGY

Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling

(2008) Gerard J. O'Sullivan et al.   NEUROPHARMACOLOGY

Opposite effects of shell or core stimulation of the nucleus accumbens on long-term potentiation in dentate gyrus of anesthetized rats

(2007) J. López et al.   NEUROSCIENCE