Seizures and gliomas — towards a single therapeutic approach

Survival benefit of levetiracetam in patients treated with concomitant chemoradiotherapy and adjuvant chemotherapy with temozolomide for glioblastoma multiforme

(2015) Young-Hoon Kim et al.   CANCER

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Individualized dosing of tyrosine kinase inhibitors: are we there yet?

(2015) Djoeke de Wit et al.   DRUG DISCOVERY TODAY

IDH1/2 mutation is associated with seizure as an initial symptom in low-grade glioma: A report of 311 Chinese adult glioma patients

(2015) Zhang Zhong et al.   EPILEPSY RESEARCH

A Phase 2 Study of Concurrent Radiation Therapy, Temozolomide, and the Histone Deacetylase Inhibitor Valproic Acid for Patients With Glioblastoma

(2015) Andra V. Krauze et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Seizure reduction is a prognostic marker in low-grade glioma patients treated with temozolomide

(2015) Johan A. F. Koekkoek et al.   JOURNAL OF NEURO-ONCOLOGY

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial

(2015) Ronit M Pressler et al.   LANCET NEUROLOGY

ATNT-10DOES VALPROIC ACID IMPROVE SURVIVAL IN GLIOBLASTOMA? A META-ANALYSIS OF RANDOMIZED TRIALS IN NEWLY DIAGNOSED GLIOBLASTOMA

(2015) Caroline Happold et al.   NEURO-ONCOLOGY

Seizure outcome after radiotherapy and chemotherapy in low-grade glioma patients: a systematic review

(2015) Johan A. F. Koekkoek et al.   NEURO-ONCOLOGY

KCC2 function modulates in vitro ictogenesis

(2015) Shabnam Hamidi et al.   NEUROBIOLOGY OF DISEASE

Evidence-based guideline: Management of an unprovoked first seizure in adults: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the American Epilepsy Society

(2015) A. Krumholz et al.   NEUROLOGY

Standard chemoradiation for glioblastoma results in progressive brain volume loss

(2015) Morgan J. Prust et al.   NEUROLOGY

Hippocampus and epilepsy: Findings from human tissues

(2015) G. Huberfeld et al.   REVUE NEUROLOGIQUE

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

(2015) Stephanie M. Robert et al.   Science Translational Medicine

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

(2015) Jared Ching et al.   Oncotarget

Current Understanding of BRAF Alterations in Diagnosis, Prognosis, and Therapeutic Targeting in Pediatric Low-Grade Gliomas

(2015) Catherine Louise Penman et al.   Frontiers in Oncology

A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

(2014) Kathrin Töllner et al.   ANNALS OF NEUROLOGY

IDH1 mutation is associated with seizures and protoplasmic subtype in patients with low-grade gliomas

(2014) Simon V. Liubinas et al.   EPILEPSIA

Could valproic acid be an effective anticancer agent? The evidence so far

(2014) Seth A Brodie et al.   Expert Review of Anticancer Therapy

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

(2014) Susan L. Campbell et al.   GLIA

Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study

(2014) Alexander Tinchon et al.   JOURNAL OF NEUROLOGY

Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models

(2014) Kaleb Yohay et al.   JOURNAL OF NEUROSURGERY

Mammalian Target of Rapamycin Inhibitors for Intractable Epilepsy and Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex

(2014) Michael Cardamone et al.   JOURNAL OF PEDIATRICS

The effect of bumetanide on photodynamic therapy-induced peri-tumor edema of C6 glioma xenografts

(2014) Xufeng Zhang et al.   LASERS IN SURGERY AND MEDICINE

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

(2014) Wen Zhu et al.   Molecular Cancer

P04.14 * IDH1 MUTATION IN LOW-GRADE GLIOMAS RELATED TO EPILEPSY AS INITIAL SYMPTOM

(2014) A. Duran-Pena et al.   NEURO-ONCOLOGY

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Characterization of metabolites in infiltrating gliomas usingex vivo1H high-resolution magic angle spinning spectroscopy

(2014) Adam Elkhaled et al.   NMR IN BIOMEDICINE

Seizure Prognosis in Brain Tumors: New Insights and Evidence-Based Management

(2014) Charles J. Vecht et al.   ONCOLOGIST

Cortical GABAergic excitation contributes to epileptic activities around human glioma

(2014) J. Pallud et al.   Science Translational Medicine

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model

(2014) N. Lozovaya et al.   Nature Communications

Biological Rationale for the Use of PPARγ Agonists in Glioblastoma

(2014) Hayley Patricia Ellis et al.   Frontiers in Oncology

Decreased inhibitory neuronal activity in patients with frontal lobe brain tumors with seizure presentation: Preliminary study using magnetoencephalography

(2013) Won Seok Chang et al.   ACTA NEUROCHIRURGICA

Everolimus treatment of refractory epilepsy in tuberous sclerosis complex

(2013) Darcy A. Krueger et al.   ANNALS OF NEUROLOGY

Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors

(2013) Don W. Coulter et al.   ANTI-CANCER DRUGS

Epileptic seizures in diffuse low-grade gliomas in adults

(2013) Johan Pallud et al.   BRAIN

BRAF V600E Mutation Is Associated with mTOR Signaling Activation in Glioneuronal Tumors

(2013) Avanita S. Prabowo et al.   BRAIN PATHOLOGY

Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials

(2013) Pritesh N. Bodalia et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells

(2013) Laurence Booth et al.   CANCER BIOLOGY & THERAPY

Drug Interactions with the Newer Antiepileptic Drugs (AEDs)—Part 1: Pharmacokinetic and Pharmacodynamic Interactions Between AEDs

(2013) Philip N. Patsalos   CLINICAL PHARMACOKINETICS

Clinical Pharmacokinetics of New-Generation Antiepileptic Drugs at the Extremes of Age: An Update

(2013) Domenico Italiano et al.   CLINICAL PHARMACOKINETICS

Seizure characteristics and prognostic factors of gliomas

(2013) Melissa Kerkhof et al.   EPILEPSIA

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

(2013) Tracy Glauser et al.   EPILEPSIA

The longer-term cognitive effects of adjunctive antiepileptic treatment with lacosamide in comparison with lamotrigine and topiramate in a naturalistic outpatient setting

(2013) Christoph Helmstaedter et al.   EPILEPSY & BEHAVIOR

Everolimus in tuberous sclerosis patients with intractable epilepsy: A treatment option?

(2013) Gert Wiegand et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism

(2013) Jakob Christensen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Correlation of IDH1/2 mutation with clinicopathologic factors and prognosis in anaplastic gliomas: a report of 203 patients from China

(2013) Chuan-Bao Zhang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Bradykinin-Induced Chemotaxis of Human Gliomas Requires the Activation of KCa3.1 and ClC-3

(2013) V. A. Cuddapah et al.   JOURNAL OF NEUROSCIENCE

Retrospective analysis of the tolerability and activity of lacosamide in patients with brain tumors

(2013) Marlon G. Saria et al.   JOURNAL OF NEUROSURGERY

Chloride extrusion enhancers as novel therapeutics for neurological diseases

(2013) Martin Gagnon et al.   NATURE MEDICINE

Quantitative characterization of the imaging limits of diffuse low-grade oligodendrogliomas

(2013) C. Gerin et al.   NEURO-ONCOLOGY

Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme

(2013) M. Kerkhof et al.   NEURO-ONCOLOGY

Seizure control following radiotherapy in patients with diffuse gliomas: a retrospective study

(2013) R. Ruda et al.   NEURO-ONCOLOGY

Glutamate and tumor-associated epilepsy: Glial cell dysfunction in the peritumoral environment

(2013) Susan C. Buckingham et al.   NEUROCHEMISTRY INTERNATIONAL

Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis

(2013) Helen S. Bateup et al.   NEURON

PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings

(2013) Monica Puligheddu et al.   PLoS One

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

Targeting the PI3K/AKT/mTOR signaling pathway in glioblastoma: novel therapeutic agents and advances in understanding

(2013) Arshawn Sami et al.   TUMOR BIOLOGY

Long-Term Epilepsy-Associated Tumors

(2012) Maria Thom et al.   BRAIN PATHOLOGY

Inhibition of Na+-K+-2Cl–Cotransporter isoform 1 Accelerates Temozolomidemediated Apoptosis in Glioblastoma Cancer Cells

(2012) Jehad Algharabil et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Enzyme induction with antiepileptic drugs: Cause for concern?

(2012) Martin J. Brodie et al.   EPILEPSIA

Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy

(2012) Sanaz Eftekhari et al.   EPILEPSIA

Monitoring the cognitive effects of antiepileptic pharmacotherapy — approaching the individual patient

(2012) Juri-Alexander Witt et al.   EPILEPSY & BEHAVIOR

Impact of antiepileptic drugs on thrombocytopenia in glioblastoma patients treated with standard chemoradiotherapy

(2012) Marta Simó et al.   JOURNAL OF NEURO-ONCOLOGY

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Levetiracetam improves verbal memory in high-grade glioma patients

(2012) Marjolein de Groot et al.   NEURO-ONCOLOGY

Intrinsic epileptogenicity of cortical tubers revealed by intracranial EEG monitoring

(2012) A. R. Mohamed et al.   NEUROLOGY

Glutamate is associated with a higher risk of seizures in patients with gliomas

(2012) T. I. Yuen et al.   NEUROLOGY

Histone deacetylase inhibitors sensitize glioblastoma cells to TRAIL-induced apoptosis by c-myc-mediated downregulation of cFLIP

(2012) A Bangert et al.   ONCOGENE

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

(2012) Anja Smits et al.   PLoS One

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

IDH1/2 mutations in WHO grade II astrocytomas associated with localization and seizure as the initial symptom

(2012) Florian Stockhammer et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Regulation of Brain Tumor Dispersal by NKCC1 Through a Novel Role in Focal Adhesion Regulation

(2012) Tomas Garzon-Muvdi et al.   PLOS BIOLOGY

With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume

(2011) Brian R. Haas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Kinase activation of ClC-3 accelerates cytoplasmic condensation during mitotic cell rounding

(2011) Vishnu Anand Cuddapah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia

(2011) Delia M. Talos et al.   ANNALS OF NEUROLOGY

Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital

(2011) Romain Nardou et al.   BRAIN

Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy

(2011) Marjolein de Groot et al.   EPILEPSIA

Factors associated with seizure freedom in the surgical resection of glioneuronal tumors

(2011) Dario J. Englot et al.   EPILEPSIA

Anomalous levels of Cl− transporters cause a decrease of GABAergic inhibition in human peritumoral epileptic cortex

(2011) Luca Conti et al.   EPILEPSIA

Predictive and prognostic factors for gliomas

(2011) François Ducray et al.   Expert Review of Anticancer Therapy

Enhancement of temozolomide-induced apoptosis by valproic acid in human glioma cell lines through redox regulation

(2011) Ching-Hsein Chen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Valproic acid sensitizes human glioma cells for temozolomide and γ-radiation

(2011) Krista A. Van Nifterik et al.   JOURNAL OF NEURO-ONCOLOGY

Hydrodynamic Cellular Volume Changes Enable Glioma Cell Invasion

(2011) S. Watkins et al.   JOURNAL OF NEUROSCIENCE

Impact of temozolomide chemotherapy on seizure frequency in patients with low-grade gliomas

(2011) Jonathan H. Sherman et al.   JOURNAL OF NEUROSURGERY

Predictors of seizure freedom after resection of supratentorial low-grade gliomas

(2011) Dario J. Englot et al.   JOURNAL OF NEUROSURGERY

Glutamate release by primary brain tumors induces epileptic activity

(2011) Susan C Buckingham et al.   NATURE MEDICINE

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

A multigene predictor of outcome in glioblastoma

(2011) H. Colman et al.   NEURO-ONCOLOGY

Enhanced GABAergic network and receptor function in pediatric cortical dysplasia Type IIB compared with Tuberous Sclerosis Complex

(2011) Carlos Cepeda et al.   NEUROBIOLOGY OF DISEASE

Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma

(2011) M. Weller et al.   NEUROLOGY

Extent of Surgical Resection Predicts Seizure Freedom in Low-Grade Temporal Lobe Brain Tumors

(2011) Dario J. Englot et al.   NEUROSURGERY

Combining antiepileptic drugs—Rational polytherapy?

(2011) Martin J. Brodie et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Efficacy and Safety of Levetiracetam in Patients With Glioma

(2010) Anna Rosati et al.   ARCHIVES OF NEUROLOGY

Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas

(2010) Fabio M. Iwamoto et al.   CANCER

Molecular mechanisms of necrosis in glioblastoma: The role of glutamate excitotoxicity

(2010) Evan Noch et al.   CANCER BIOLOGY & THERAPY

Inhibition of the Sodium-Potassium-Chloride Cotransporter Isoform-1 Reduces Glioma Invasion

(2010) B. R. Haas et al.   CANCER RESEARCH

Survival of Patients with Newly Diagnosed Glioblastoma Treated with Radiation and Temozolomide in Research Studies in the United States

(2010) S. A. Grossman et al.   CLINICAL CANCER RESEARCH

Brain damage from anticancer treatments in adults

(2010) Damien Ricard et al.   CURRENT OPINION IN ONCOLOGY

Guidelines on management of low-grade gliomas: report of an EFNS-EANO* Task Force

(2010) R. Soffietti et al.   EUROPEAN JOURNAL OF NEUROLOGY

Glutamate and the biology of gliomas

(2010) John de Groot et al.   GLIA

Inverse association of PPARγ agonists use and high grade glioma development

(2010) Christian Grommes et al.   JOURNAL OF NEURO-ONCOLOGY

Levetiracetam monotherapy in patients with brain tumor-related epilepsy: seizure control, safety, and quality of life

(2010) Marta Maschio et al.   JOURNAL OF NEURO-ONCOLOGY

Progressive NKCC1-Dependent Neuronal Chloride Accumulation during Neonatal Seizures

(2010) V. I. Dzhala et al.   JOURNAL OF NEUROSCIENCE

Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide

(2010) George C. Bobustuc et al.   NEURO-ONCOLOGY

Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-γ-lyase and upregulation of the transsulfuration pathway in C6 glioma cells

(2010) Sarah Kandil et al.   NEUROCHEMISTRY INTERNATIONAL

IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas

(2010) C. Houillier et al.   NEUROLOGY

Diffuse low-grade oligodendrogliomas extend beyond MRI-defined abnormalities

(2010) J. Pallud et al.   NEUROLOGY

Everolimus for Subependymal Giant-Cell Astrocytomas in Tuberous Sclerosis

(2010) Darcy A. Krueger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rational polytherapy

(2009) Jacqueline A. French et al.   EPILEPSIA

Expression of glutamate receptor subunits in human cancers

(2009) Andrzej Stepulak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Decreased Seizure Activity in a Human Neonate Treated With Bumetanide, an Inhibitor of the Na+-K+-2Cl- Cotransporter NKCC1

(2009) Kristopher T. Kahle et al.   JOURNAL OF CHILD NEUROLOGY

Talampanel With Standard Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma: A Multicenter Phase II Trial

(2009) Stuart A. Grossman et al.   JOURNAL OF CLINICAL ONCOLOGY

Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas

(2009) Marc Sanson et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines

(2009) Hani J. Marcus et al.   JOURNAL OF NEURO-ONCOLOGY

Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas

(2009) Kaisorn L. Chaichana et al.   JOURNAL OF NEUROSURGERY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches

(2009) Stephanie Z. Young et al.   PHYSIOLOGY

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Quantitative Assessment of Postoperative Blood Collection in Brain Tumor Surgery Under Valproate Medication

(2008) T. Psaras et al.   ZENTRALBLATT FUR NEUROCHIRURGIE

Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam

(2008) Rafal M. Kaminski et al.   EPILEPSIA

The effects of levetiracetam on cognition: A non-interventional surveillance study

(2008) Christoph Helmstaedter et al.   EPILEPSY & BEHAVIOR

An Unexpected Role for Ion Channels in Brain Tumor Metastasis

(2008) Harald Sontheimer   EXPERIMENTAL BIOLOGY AND MEDICINE

Temozolomide treatment does not affect topiramate and oxcarbazepine plasma concentrations in chronically treated patients with brain tumor-related epilepsy

(2008) Marta Maschio et al.   JOURNAL OF NEURO-ONCOLOGY

Knockdown of GluR1 expression by RNA interference inhibits glioma proliferation

(2008) John F. de Groot et al.   JOURNAL OF NEURO-ONCOLOGY

Layer-Specific Generation and Propagation of Seizures in Slices of Developing Neocortex: Role of Excitatory GABAergic Synapses

(2008) Sylvain Rheims et al.   JOURNAL OF NEUROPHYSIOLOGY

Chloride Accumulation Drives Volume Dynamics Underlying Cell Proliferation and Migration

(2008) Christa W. Habela et al.   JOURNAL OF NEUROPHYSIOLOGY

ClC3 Is a Critical Regulator of the Cell Cycle in Normal and Malignant Glial Cells

(2008) C. W. Habela et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Seizure characteristics and control following resection in 332 patients with low-grade gliomas

(2008) Edward F. Chang et al.   JOURNAL OF NEUROSURGERY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Small interfering RNA–mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema

(2008) Nicolai E Savaskan et al.   NATURE MEDICINE