Emerging technologies to study glial cells

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

(2019) Michael A. Wheeler et al.   CELL

Melanopsin for precise optogenetic activation of astrocyte-neuron networks

(2019) Sara Mederos et al.   GLIA

Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex

(2019) Alexandros Poulopoulos et al.   NATURE

Cell-Type-Specific Gene Expression Profiling in Adult Mouse Brain Reveals Normal and Disease-State Signatures

(2019) Nicolas Merienne et al.   Cell Reports

Therapeutic AAV Gene Transfer to the Nervous System: A Clinical Reality

(2019) Eloise Hudry et al.   NEURON

Adeno-associated virus vector as a platform for gene therapy delivery

(2019) Dan Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

(2019) Chee-Huat Linus Eng et al.   NATURE

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution

(2019) Takahiro Masuda et al.   NATURE

Altered human oligodendrocyte heterogeneity in multiple sclerosis

(2019) Sarah Jäkel et al.   NATURE

Association between pathological and MRI findings in multiple sclerosis

(2019) Massimo Filippi et al.   LANCET NEUROLOGY

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

(2019) Jun Nagai et al.   CELL

A roadmap to integrate astrocytes into Systems Neuroscience

(2019) Ksenia V. Kastanenka et al.   GLIA

Uncovering the biology of myelin with optical imaging of the live brain

(2019) Robert A. Hill et al.   GLIA

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications

(2019) Amaia M Arranz et al.   LANCET NEUROLOGY

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Diffusion-weighted magnetic resonance spectroscopy enables cell-specific monitoring of astrocyte reactivity in vivo

(2019) Clémence Ligneul et al.   NEUROIMAGE

Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification

(2019) Brian S. Clark et al.   NEURON

Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

(2019) Jacob S. Heng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell genomics identifies cell type–specific molecular changes in autism

(2019) Dmitry Velmeshev et al.   SCIENCE

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

(2019) J. Christopher Octeau et al.   Cell Reports

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

(2019) Geng Chen et al.   Frontiers in Genetics

Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina

(2019) Levi Todd et al.   Journal of Neuroinflammation

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Sharpening the tools for pericyte research

(2019) Andrée-Anne Berthiaume et al.   NATURE NEUROSCIENCE

Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

(2019) Georgia Gunner et al.   NATURE NEUROSCIENCE

Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo

(2019) Jonathan Hasselmann et al.   NEURON

Bright and photostable chemigenetic indicators for extended in vivo voltage imaging

(2019) Ahmed S. Abdelfattah et al.   SCIENCE

Targeting microglia in brain disorders

(2019) Josef Priller et al.   SCIENCE

A single‐cell transcriptome atlas of the adult human retina

(2019) Samuel W Lukowski et al.   EMBO JOURNAL

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

Conserved cell types with divergent features in human versus mouse cortex

(2019) Rebecca D. Hodge et al.   NATURE

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

Single-cell transcriptomic profiling of the aging mouse brain

(2019) Methodios Ximerakis et al.   NATURE NEUROSCIENCE

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Astrocyte transduction is required for rescue of behavioral phenotypes in the YAC128 mouse model with AAV-RNAi mediated HTT lowering therapeutics

(2019) Lisa M. Stanek et al.   NEUROBIOLOGY OF DISEASE

Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges

(2019) Margaret E. Maes et al.   NEUROSCIENCE LETTERS

Specialized cutaneous Schwann cells initiate pain sensation

(2019) Hind Abdo et al.   SCIENCE

The landscape of myeloid and astrocyte phenotypes in acute multiple sclerosis lesions

(2019) Calvin Park et al.   Acta Neuropathologica Communications

Microglia Biology: One Century of Evolving Concepts

(2019) Marco Prinz et al.   CELL

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

(2019) Renzo Mancuso et al.   NATURE NEUROSCIENCE

Imaging neuromodulators with high spatiotemporal resolution using genetically encoded indicators

(2019) Tommaso Patriarchi et al.   Nature Protocols

Cross-Species Single-Cell Analysis Reveals Divergence of the Primate Microglia Program

(2019) Laufey Geirsdottir et al.   CELL

Biological Insight from Super-Resolution Microscopy: What We Can Learn from Localization-Based Images

(2018) David Baddeley et al.   Annual Review of Biochemistry

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

(2018) Xiaoying Fan et al.   CELL RESEARCH

The Versatile Tanycyte: A Hypothalamic Integrator of Reproduction and Energy Metabolism

(2018) Vincent Prevot et al.   ENDOCRINE REVIEWS

Placing RNA in context and space - methods for spatially resolved transcriptomics

(2018) Carina Strell et al.   FEBS Journal

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response

(2018) Teng Jiang et al.   INFLAMMATION

Single-cell RNA sequencing: Technical advancements and biological applications

(2018) Eva Hedlund et al.   MOLECULAR ASPECTS OF MEDICINE

Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer’s Disease Therapeutic Target

(2018) Sudhanshu P. Raikwar et al.   MOLECULAR NEUROBIOLOGY

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies

(2018) Zhana Haimon et al.   NATURE IMMUNOLOGY

CRISPR interference-based specific and efficient gene inactivation in the brain

(2018) Yi Zheng et al.   NATURE NEUROSCIENCE

In vivo simultaneous transcriptional activation of multiple genes in the brain using CRISPR–dCas9-activator transgenic mice

(2018) Haibo Zhou et al.   NATURE NEUROSCIENCE

Myelin remodeling through experience-dependent oligodendrogenesis in the adult somatosensory cortex

(2018) Ethan G. Hughes et al.   NATURE NEUROSCIENCE

Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain

(2018) Robert A. Hill et al.   NATURE NEUROSCIENCE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

A stocked toolbox for understanding the role of astrocytes in disease

(2018) Akshata Almad et al.   Nature Reviews Neurology

A Combination of Ontogeny and CNS Environment Establishes Microglial Identity

(2018) F. Chris Bennett et al.   NEURON

At the Origin of the History of Glia

(2018) Xue Fan et al.   NEUROSCIENCE

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement

(2018) Brian T. Kalish et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

(2018) Mithilesh Kumar Jha et al.   PROGRESS IN NEUROBIOLOGY

Three-dimensional intact-tissue sequencing of single-cell transcriptional states

(2018) Xiao Wang et al.   SCIENCE

Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics

(2018) Jan Verheijen et al.   TRENDS IN GENETICS

Cell Type-Specific Optogenetic Dissection of Brain Rhythms

(2018) Hillel Adesnik   TRENDS IN NEUROSCIENCES

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration

(2018) Christina Ising et al.   Cell Death & Disease

A transcriptomic atlas of aged human microglia

(2018) Marta Olah et al.   Nature Communications

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

All-Optical Electrophysiology for High-Throughput Functional Characterization of a Human iPSC-Derived Motor Neuron Model of ALS

(2018) Evangelos Kiskinis et al.   Stem Cell Reports

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

(2018) Bumwhee Lee et al.   Nature Biomedical Engineering

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Molecular Architecture of the Mouse Nervous System

(2018) Amit Zeisel et al.   CELL

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

(2018) Sueli Marques et al.   DEVELOPMENTAL CELL

Sequentially acting SOX proteins orchestrate astrocyte‐ and oligodendrocyte‐specific gene expression

(2018) Susanne Klum et al.   EMBO REPORTS

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures

(2018) Carole Sousa et al.   EMBO REPORTS

Single cell protein analysis for systems biology

(2018) Ezra Levy et al.   Essays in Biochemistry

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments

(2018) Francesco Petrelli et al.   MOLECULAR PSYCHIATRY

Innate immune memory in the brain shapes neurological disease hallmarks

(2018) Ann-Christin Wendeln et al.   NATURE

Induction of myelinating oligodendrocytes in human cortical spheroids

(2018) Mayur Madhavan et al.   NATURE METHODS

Gene therapy for neurological disorders: progress and prospects

(2018) Benjamin E. Deverman et al.   NATURE REVIEWS DRUG DISCOVERY

Neuroinflammation in Neurodegenerative Diseases: Current Multi-modal Imaging Studies and Future Opportunities for Hybrid PET/MRI

(2018) Marco Aiello et al.   NEUROSCIENCE

Epigenetics Control Microglia Plasticity

(2018) Mathilde Cheray et al.   Frontiers in Cellular Neuroscience

Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer’s disease mouse model 5xFAD

(2018) Antonio Boza-Serrano et al.   Scientific Reports

Transcriptional and Translational Differences of Microglia from Male and Female Brains

(2018) Dilansu Guneykaya et al.   Cell Reports

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia

(2018) Denis Avey et al.   Cell Reports

The Kaleidoscope of Microglial Phenotypes

(2018) Marissa L. Dubbelaar et al.   Frontiers in Immunology

In vivo Imaging of Glial Activation in Alzheimer's Disease

(2018) Paul Edison et al.   Frontiers in Neurology

Long-Term Follow-Up of a Phase I/II Study of ProSavin, a Lentiviral Vector Gene Therapy for Parkinson's Disease

(2018) Stéphane Palfi et al.   Human Gene Therapy Clinical Development

Emerging PET Radiotracers and Targets for Imaging of Neuroinflammation in Neurodegenerative Diseases: Outlook Beyond TSPO

(2018) Vidya Narayanaswami et al.   Molecular Imaging

Unique microglia recovery population revealed by single-cell RNAseq following neurodegeneration

(2018) Tuan Leng Tay et al.   Acta Neuropathologica Communications

The biology of the cell - insights from mass cytometry

(2018) Petter Brodin   FEBS Journal

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Astrocytes and microglia: Models and tools

(2018) Kevin A. Guttenplan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma

(2018) Christian U. Blank et al.   NATURE MEDICINE

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

(2018) Ana Mendanha Falcão et al.   NATURE MEDICINE

Single-cell proteomics

(2018) Allison Doerr   NATURE METHODS

Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry

(2018) Chotima Böttcher et al.   NATURE NEUROSCIENCE

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

Single-nucleus and single-cell transcriptomes compared in matched cortical cell types

(2018) Trygve E. Bakken et al.   PLoS One

Glia as architects of central nervous system formation and function

(2018) Nicola J. Allen et al.   SCIENCE

Microglia and early brain development: An intimate journey

(2018) Morgane S. Thion et al.   SCIENCE

Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype

(2018) Attya Omer Javed et al.   Cell Reports

Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes

(2017) Christine Kunze et al.   GLIA

Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function

(2017) Kazuyuki Takata et al.   IMMUNITY

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease

(2017) S.K. Powell et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization

(2017) Brock Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Comparative Analysis of Single-Cell RNA Sequencing Methods

(2017) Christoph Ziegenhain et al.   MOLECULAR CELL

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Labeling and identifying cell-specific proteomes in the mouse brain

(2017) Toke P Krogager et al.   NATURE BIOTECHNOLOGY

Cell-type-specific metabolic labeling of nascent proteomes in vivo

(2017) Beatriz Alvarez-Castelao et al.   NATURE BIOTECHNOLOGY

Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

(2017) Thais F Galatro et al.   NATURE NEUROSCIENCE

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Synapse-specific astrocyte gating of amygdala-related behavior

(2017) Mario Martin-Fernandez et al.   NATURE NEUROSCIENCE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Differentiation of human and murine induced pluripotent stem cells to microglia-like cells

(2017) Hetal Pandya et al.   NATURE NEUROSCIENCE

Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

(2017) Sinisa Hrvatin et al.   NATURE NEUROSCIENCE

Neuronal cell-type classification: challenges, opportunities and the path forward

(2017) Hongkui Zeng et al.   NATURE REVIEWS NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Detecting Activated Cell Populations Using Single-Cell RNA-Seq

(2017) Ye Emily Wu et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

(2017) Jerry R. Mendell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection

(2017) Sean L. Hammond et al.   PLoS One

Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex

(2017) Tomasz J. Nowakowski et al.   SCIENCE

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

Targeted two-photon chemical apoptotic ablation of defined cell types in vivo

(2017) Robert A. Hill et al.   Nature Communications

Gene suppression approaches to neurodegeneration

(2017) Rhia Ghosh et al.   Alzheimers Research & Therapy

Single-Cell RNA-Seq Reveals Hypothalamic Cell Diversity

(2017) Renchao Chen et al.   Cell Reports

The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes

(2017) Nicolas Merienne et al.   Cell Reports

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

(2017) Hansruedi Mathys et al.   Cell Reports

Microglia Responses in Acute and Chronic Neurological Diseases: What Microglia-Specific Transcriptomic Studies Taught (and did Not Teach) Us

(2017) Hélène E. Hirbec et al.   Frontiers in Aging Neuroscience

Pseudotyped Lentiviral Vectors: One Vector, Many Guises

(2017) Alok V. Joglekar et al.   Human Gene Therapy Methods

Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities

(2017) Maria Schnödt et al.   Human Gene Therapy Methods

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC 1 D-Driven Transgene Expression in AAV-Mediated Gene Transfer

(2017) Grit Taschenberger et al.   Molecular Therapy-Nucleic Acids

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation

(2017) Leslie Mazuel et al.   PLoS One

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA

(2017) Blue B. Lake et al.   Scientific Reports

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

(2016) Benedetta Bodini et al.   ANNALS OF NEUROLOGY

Early and protective microglial activation in Alzheimer’s disease: a prospective study using18F-DPA-714 PET imaging

(2016) Lorraine Hamelin et al.   BRAIN

Epigenetics in NG2 glia cells

(2016) Sarah Moyon et al.   BRAIN RESEARCH

Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells

(2016) Gioele La Manno et al.   CELL

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells

(2016) Tomasz J. Nowakowski et al.   Cell Stem Cell

Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism

(2016) S K Powell et al.   GENE THERAPY

Activation of hypothalamic astrocytes suppresses feeding without altering emotional states

(2016) Patrick Sweeney et al.   GLIA

Glial cells as drug targets: What does it take?

(2016) Thomas Möller et al.   GLIA

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

(2016) Cécile Meunier et al.   GLIA

Glial biomarkers in human central nervous system disease

(2016) Gwenn A. Garden et al.   GLIA

Gene therapy for the CNS using AAVs: The impact of systemic delivery by AAV9

(2016) Joana Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Binaural blood flow control by astrocytes: listening to synapses and the vasculature

(2016) Anusha Mishra   JOURNAL OF PHYSIOLOGY-LONDON

Enteric glia: the most alimentary of all glia

(2016) Vladimir Grubišić et al.   JOURNAL OF PHYSIOLOGY-LONDON

In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy

(2016) Sourav R Choudhury et al.   MOLECULAR THERAPY

An essential receptor for adeno-associated virus infection

(2016) S. Pillay et al.   NATURE

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

The origin and evolution of cell types

(2016) Detlev Arendt et al.   NATURE REVIEWS GENETICS

The time course of systems consolidation of spatial memory from recent to remote retention: A comparison of the Immediate Early Genes Zif268, c-Fos and Arc

(2016) Daniel N. Barry et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

(2016) Teng Jiang et al.   NEUROPHARMACOLOGY

New paradigm to assess brain cell morphology by diffusion-weighted MR spectroscopy in vivo

(2016) Marco Palombo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Identification of an elaborate complex mediating postsynaptic inhibition

(2016) A. Uezu et al.   SCIENCE

Recombinant Adeno-Associated Virus Serotype 6 (rAAV6) Potently and Preferentially Transduces Rat Astrocytes In vitro and In vivo

(2016) Alexandra L. Schober et al.   Frontiers in Cellular Neuroscience

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease

(2016) Abdellatif Benraiss et al.   Nature Communications

Nuclear RNA-seq of single neurons reveals molecular signatures of activation

(2016) Benjamin Lacar et al.   Nature Communications

Persistent Alterations in Microglial Enhancers in a Model of Chronic Pain

(2016) Franziska Denk et al.   Cell Reports

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

(2016) Marco Onorati et al.   Cell Reports

Cellular transduction mechanisms of adeno-associated viral vectors

(2016) Garrett Edward Berry et al.   Current Opinion in Virology

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

(2016) Naiyan Chen et al.   eLife

Widespread AAV1- and AAV2-mediated transgene expression in the nonhuman primate brain: implications for Huntington's disease

(2016) Piotr Hadaczek et al.   Molecular Therapy-Methods & Clinical Development

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Glia in mammalian development and disease

(2015) J. Bradley Zuchero et al.   DEVELOPMENT

Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice

(2015) Dheeraj Pelluru et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Gene transfer engineering for astrocyte-specific silencing in the CNS

(2015) N Merienne et al.   GENE THERAPY

The Neuroprotective Agent CNTF Decreases Neuronal Metabolites in the Rat Striatum: An in Vivo Multimodal Magnetic Resonance Imaging Study

(2015) Maria-Angeles Carrillo-de Sauvage et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Inducible in vivo genome editing with CRISPR-Cas9

(2015) Lukas E Dow et al.   NATURE BIOTECHNOLOGY

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages

(2015) Andrea Ditadi et al.   NATURE CELL BIOLOGY

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Ca2+ signaling in astrocytes from Ip3r2 −/− mice in brain slices and during startle responses in vivo

(2015) Rahul Srinivasan et al.   NATURE NEUROSCIENCE

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Glial Development and Function in the Nervous System ofCaenorhabditis elegans

(2015) Shai Shaham   Cold Spring Harbor Perspectives in Biology

DrosophilaCentral Nervous System Glia

(2015) Marc R. Freeman   Cold Spring Harbor Perspectives in Biology

Oligodendrocyte Development and Plasticity

(2015) Dwight E. Bergles et al.   Cold Spring Harbor Perspectives in Biology

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

(2015) Yuta Kohro et al.   Scientific Reports

In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

(2015) Eric Zinn et al.   Cell Reports

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Genetic targeting of microglia

(2014) Peter Wieghofer et al.   GLIA

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Wnt signaling controls the specification of definitive and primitive hematopoiesis from human pluripotent stem cells

(2014) Christopher M Sturgeon et al.   NATURE BIOTECHNOLOGY

Label-free in vivo imaging of myelinated axons in health and disease with spectral confocal reflectance microscopy

(2014) Aaron J Schain et al.   NATURE MEDICINE

Decoding neuroproteomics: integrating the genome, translatome and functional anatomy

(2014) Robert R Kitchen et al.   NATURE NEUROSCIENCE

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion

(2014) Ulrike Pannasch et al.   NATURE NEUROSCIENCE

Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway

(2014) Martin D. Haustein et al.   NEURON

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

(2014) Cecilia Bull et al.   NEUROPSYCHOPHARMACOLOGY

Secretome Analysis of Human Oligodendrocytes Derived from Neural Stem Cells

(2014) Woo Kyung Kim et al.   PLoS One

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

(2014) Sung S. Choi et al.   PLoS One

BMP Signaling in Astrocytes Downregulates EGFR to Modulate Survival and Maturation

(2014) Anja R. Scholze et al.   PLoS One

Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex

(2014) G. S. Tomassy et al.   SCIENCE

Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain

(2014) Akira Yamashita et al.   SYNAPSE

The optogenetic revolution in memory research

(2014) Inbal Goshen   TRENDS IN NEUROSCIENCES

Glial Cell Development and Function in Zebrafish

(2014) David A. Lyons et al.   Cold Spring Harbor Perspectives in Biology

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Biology of adeno-associated viral vectors in the central nervous system

(2014) Giridhar Murlidharan et al.   Frontiers in Molecular Neuroscience

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

(2014) Panagiotis Douvaras et al.   Stem Cell Reports

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

Protein Analysis by Shotgun/Bottom-up Proteomics

(2013) Yaoyang Zhang et al.   CHEMICAL REVIEWS

Probing the enigma: unraveling glial cell biology in invertebrates

(2013) Jaeda Coutinho-Budd et al.   CURRENT OPINION IN NEUROBIOLOGY

Strong Cortical and Spinal Cord Transduction After AAV7 and AAV9 Delivery into the Cerebrospinal Fluid of Nonhuman Primates

(2013) Lluis Samaranch et al.   HUMAN GENE THERAPY

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain

(2013) Ethan G Hughes et al.   NATURE NEUROSCIENCE

In vivo three-photon microscopy of subcortical structures within an intact mouse brain

(2013) Nicholas G. Horton et al.   Nature Photonics

Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9

(2013) Malin Åkerblom et al.   Nature Communications

An Optimized microRNA Backbone for Effective Single-Copy RNAi

(2013) Christof Fellmann et al.   Cell Reports

Metabolic Aspects of Neuron-Oligodendrocyte-Astrocyte Interactions

(2013) Ana I. Amaral et al.   Frontiers in Endocrinology

Lentiviral vectors: basic to translational

(2012) Toshie Sakuma et al.   BIOCHEMICAL JOURNAL

The secretome signature of reactive glial cells and its pathological implications

(2012) Mithilesh Kumar Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Preinspiratory calcium rise in putative pre-Bötzinger complex astrocytes

(2012) Yasumasa Okada et al.   JOURNAL OF PHYSIOLOGY-LONDON

The AAV Vector Toolkit: Poised at the Clinical Crossroads

(2012) Aravind Asokan et al.   MOLECULAR THERAPY

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors

(2012) Nicola J. Allen et al.   NATURE

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

Imaging Calcium in Neurons

(2012) Christine Grienberger et al.   NEURON

Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation

(2012) T. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploiting microRNA regulation for genetic engineering

(2012) B. Gentner et al.   TISSUE ANTIGENS

The Development and Application of Optogenetics

(2011) Lief Fenno et al.   Annual Review of Neuroscience

In Vivo Imaging of Myelin in the Vertebrate Central Nervous System Using Third Harmonic Generation Microscopy

(2011) Matthew J. Farrar et al.   BIOPHYSICAL JOURNAL

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

TerminalN-Linked Galactose Is the Primary Receptor for Adeno-associated Virus 9

(2011) Shen Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is the magnetization transfer ratio a marker for myelin in multiple sclerosis?

(2011) Irene M. Vavasour et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Cell Type-Specific Transcriptomics in the Brain

(2011) B. W. Okaty et al.   JOURNAL OF NEUROSCIENCE

Preclinical Differences of Intravascular AAV9 Delivery to Neurons and Glia: A Comparative Study of Adult Mice and Nonhuman Primates

(2011) Steven J Gray et al.   MOLECULAR THERAPY

Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery

(2011) Anja Drinkut et al.   MOLECULAR THERAPY

CD140a identifies a population of highly myelinogenic, migration-competent and efficiently engrafting human oligodendrocyte progenitor cells

(2011) Fraser J Sim et al.   NATURE BIOTECHNOLOGY

Miniaturized integration of a fluorescence microscope

(2011) Kunal K Ghosh et al.   NATURE METHODS

Directed differentiation of functional astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   Nature Protocols

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra

(2010) Jason R. Cannon et al.   EXPERIMENTAL NEUROLOGY

Combined analysis of the glia secretome and the CSF proteome: neuroinflammation and novel biomarkers

(2010) Kyoungho Suk   Expert Review of Proteomics

Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle α-actin gene

(2010) John J. Armstrong et al.   GENESIS

Imaging biomarkers in multiple sclerosis

(2010) M. Filippi et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells

(2010) Mingjie Li et al.   JOURNAL OF NEUROSCIENCE METHODS

Scanless two-photon excitation of channelrhodopsin-2

(2010) Eirini Papagiakoumou et al.   NATURE METHODS

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Hippocampal Short- and Long-Term Plasticity Are Not Modulated by Astrocyte Ca2+ Signaling

(2010) C. Agulhon et al.   SCIENCE

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Functional Control of Transplantable Human ESC-Derived Neurons Via Optogenetic Targeting

(2010) Jason P. Weick et al.   STEM CELLS

Sustained effects of nonallele-specificHuntingtinsilencing

(2009) Valérie Drouet et al.   ANNALS OF NEUROLOGY

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects

(2009) B.-Y. Hu et al.   DEVELOPMENT

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Efficient Gene Delivery and Selective Transduction of Glial Cells in the Mammalian Brain by AAV Serotypes Isolated From Nonhuman Primates

(2009) Patricia A Lawlor et al.   MOLECULAR THERAPY

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

Neuroproteomics: understanding the molecular organization and complexity of the brain

(2009) Alex Bayés et al.   NATURE REVIEWS NEUROSCIENCE

Gliopathic Pain: When Satellite Glial Cells Go Bad

(2009) Peter T. Ohara et al.   NEUROSCIENTIST

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Deconstruction of Parkinsonian Neural Circuitry

(2009) V. Gradinaru et al.   SCIENCE

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

(2009) N. Cartier et al.   SCIENCE

Spike Timing–Dependent Plasticity: A Hebbian Learning Rule

(2008) Natalia Caporale et al.   Annual Review of Neuroscience

Getting to the Root of miRNA-Mediated Gene Silencing

(2008) Ana Eulalio et al.   CELL

Applications of Lentiviral Vectors for Biology and Gene Therapy of Neurological Disorders

(2008) Cecilia Lundberg et al.   CURRENT GENE THERAPY

Bioimaging of the unbalanced expression of microRNA9 and microRNA9* during the neuronal differentiation of P19 cells

(2008) Mee Hyang Ko et al.   FEBS Journal

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

NS21: Re-defined and modified supplement B27 for neuronal cultures

(2008) Yucui Chen et al.   JOURNAL OF NEUROSCIENCE METHODS

In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses

(2008) D. Grimm et al.   JOURNAL OF VIROLOGY

Expanded Repertoire of AAV Vector Serotypes Mediate Unique Patterns of Transduction in Mouse Brain

(2008) Cassia N Cearley et al.   MOLECULAR THERAPY

Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes

(2008) Kevin D Foust et al.   NATURE BIOTECHNOLOGY

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

(2008) Trent A. Watkins et al.   NEURON

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

(2007) Ronald L Klein et al.   MOLECULAR THERAPY

Expression of GDNF transgene in astrocytes improves cognitive deficits in aged rats

(2007) M. Pertusa et al.   NEUROBIOLOGY OF AGING