Targeted Gene Editing of Glia Maturation Factor in Microglia: a Novel Alzheimer’s Disease Therapeutic Target

MicroRNA-132 attenuates LPS-induced inflammatory injury by targeting TRAF6 in neuronal cell line HT-22

(2018) Yang-Fei Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells

(2018) Govindhasamy Pushpavathi Selvakumar et al.   MOLECULAR NEUROBIOLOGY

Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease

(2018) Lawrence S. Honig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

(2017) Mohammad Ejaz Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

The application of CRISPR technology to high content screening in primary neurons

(2017) Ben L. Callif et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

CRISPR fixes disease gene in viable human embryos

(2017) Heidi Ledford   NATURE

Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes

(2017) Brett T Staahl et al.   NATURE BIOTECHNOLOGY

Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain

(2017) Jun Nishiyama et al.   NEURON

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

(2017) Svetlana Di Benedetto et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration

(2017) Duraisamy Kempuraj et al.   Frontiers in Cellular Neuroscience

Muscle-specific CRISPR/Cas9 dystrophin gene editing ameliorates pathophysiology in a mouse model for Duchenne muscular dystrophy

(2017) Niclas E. Bengtsson et al.   Nature Communications

Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer’s Disease Brain

(2017) Ramasamy Thangavel et al.   Frontiers in Aging Neuroscience

A MicroRNA124 Target Sequence Restores Astrocyte Specificity of gfaABC 1 D-Driven Transgene Expression in AAV-Mediated Gene Transfer

(2017) Grit Taschenberger et al.   Molecular Therapy-Nucleic Acids

Broad-Spectrum Inhibition of Respiratory Virus Infection by MicroRNA Mimics Targeting p38 MAPK Signaling

(2017) Jana L. McCaskill et al.   Molecular Therapy-Nucleic Acids

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells

(2016) Courtney S. Young et al.   Cell Stem Cell

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

(2016) Evgenia Salta et al.   EMBO Molecular Medicine

Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

(2016) Andrea Crotti et al.   IMMUNITY

Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia

(2016) Dean Q. Tran et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

CRISPR gene-editing tested in a person for the first time

(2016) David Cyranoski   NATURE

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

(2016) Frank Soldner et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

(2016) Yang Yang et al.   NATURE BIOTECHNOLOGY

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition

(2016) Elizabeth A Traxler et al.   NATURE MEDICINE

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector

(2016) Giridhar Murlidharan et al.   Molecular Therapy-Nucleic Acids

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice

(2016) Julia Hernandez-Rapp et al.   Scientific Reports

Functional Correction of Large Factor VIII Gene Chromosomal Inversions in Hemophilia A Patient-Derived iPSCs Using CRISPR-Cas9

(2015) Chul-Yong Park et al.   Cell Stem Cell

Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1

(2015) Laura Schnöder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recombinant adeno-associated viral (rAAV) vectors mediate efficient gene transduction in cultured neonatal and adult microglia

(2015) Wei Su et al.   JOURNAL OF NEUROCHEMISTRY

Determining the role of IL-4 induced neuroinflammation in microglial activity and amyloid-β using BV2 microglial cells and APP/PS1 transgenic mice

(2015) Clare H Latta et al.   Journal of Neuroinflammation

In vivo genome editing using Staphylococcus aureus Cas9

(2015) F. Ann Ran et al.   NATURE

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

(2015) M. Tabebordbar et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

(2015) Marc Zuckermann et al.   Nature Communications

Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9

(2014) Pankaj K. Mandal et al.   Cell Stem Cell

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

(2014) Lukasz Swiech et al.   NATURE BIOTECHNOLOGY

Suppression of glia maturation factor expression prevents 1-methyl-4-phenylpyridinium (MPP+)-induced loss of mesencephalic dopaminergic neurons

(2014) M.M. Khan et al.   NEUROSCIENCE

Phase 3 Trials of Solanezumab and Bapineuzumab for Alzheimer's Disease

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Glia Maturation Factor Expression in Hippocampus of Human Alzheimer’s Disease

(2013) Deirdre Stolmeier et al.   NEUROCHEMICAL RESEARCH

Glia Maturation Factor Expression in Entorhinal Cortex of Alzheimer’s Disease Brain

(2013) Ramasamy Thangavel et al.   NEUROCHEMICAL RESEARCH

AAV2/8 Vectors Purified from Culture Medium with a Simple and Rapid Protocol Transduce Murine Liver, Muscle, and Retina Efficiently

(2013) Monica Doria et al.   Human Gene Therapy Methods

Enhanced Expression of Glia Maturation Factor Correlates with Glial Activation in the Brain of Triple Transgenic Alzheimer’s Disease Mice

(2012) Smita Zaheer et al.   NEUROCHEMICAL RESEARCH

Expression of glia maturation factor in neuropathological lesions of Alzheimer's disease

(2011) R. Thangavel et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Augmented expression of glia maturation factor in Alzheimer's disease

(2011) S. Zaheer et al.   NEUROSCIENCE

Efficient Serotype-Dependent Release of Functional Vector into the Culture Medium During Adeno-Associated Virus Manufacturing

(2010) Luk H. Vandenberghe et al.   HUMAN GENE THERAPY

Generation of microglial cells from mouse embryonic stem cells

(2010) Clara Beutner et al.   Nature Protocols

Glia maturation factor modulates β-amyloid-induced glial activation, inflammatory cytokine/chemokine production and neuronal damage

(2008) Asgar Zaheer et al.   BRAIN RESEARCH

Activation of MKK6, an upstream activator of p38, in Alzheimer's disease

(2003) Xiongwei Zhu et al.   JOURNAL OF NEUROCHEMISTRY

p38 Kinase Is Activated in the Alzheimer's Disease Brain

(2003) Kenneth Hensley et al.   JOURNAL OF NEUROCHEMISTRY