Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice

(2016) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Gene transfer engineering for astrocyte-specific silencing in the CNS

(2015) N Merienne et al.   GENE THERAPY

Moving toward a gene therapy for Huntington’s disease

(2015) J C Glorioso et al.   GENE THERAPY

Association of brain immune genes with social behavior of inbred mouse strains

(2015) Li Ma et al.   Journal of Neuroinflammation

Treating the whole body in Huntington's disease

(2015) Jeffrey B Carroll et al.   LANCET NEUROLOGY

Do glia drive synaptic and cognitive impairment in disease?

(2015) Won-Suk Chung et al.   NATURE NEUROSCIENCE

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms

(2014) Patrick Pla et al.   Frontiers in Behavioral Neuroscience

Efficient gene delivery and selective transduction of astrocytes in the mammalian brain using viral vectors

(2013) Nicolas Merienne et al.   Frontiers in Cellular Neuroscience

A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington’s disease in mice

(2013) Aníbal I. Acuña et al.   Nature Communications

Self-induced accumulation of glutamate in striatal astrocytes and basal ganglia excitotoxicity

(2012) Ingrid Morales et al.   GLIA

A novel cross-talk between endothelin and ErbB receptors controlling glutamate transporter expression in astrocytes

(2012) Darko Glisic et al.   JOURNAL OF NEUROCHEMISTRY

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease

(2012) Zhihong Guo et al.   MOVEMENT DISORDERS

Potential translational targets revealed by linking mouse grooming behavioral phenotypes to gene expression using public databases

(2012) Andrew Roth et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species

(2012) Steffen J. Sahl et al.   Scientific Reports

Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits

(2011) Sofia Hult et al.   Cell Metabolism

Pharmacologic approaches to the treatment of Huntington's disease

(2011) Charles S. Venuto et al.   MOVEMENT DISORDERS

Huntington's disease: a clinical review

(2011) Raymund A.C. Roos   Orphanet Journal of Rare Diseases

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

(2010) M. Faideau et al.   HUMAN MOLECULAR GENETICS

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

(2010) Chiara Zuccato et al.   PHYSIOLOGICAL REVIEWS

Adipose tissue dysfunction tracks disease progression in two Huntington's disease mouse models

(2009) Jack Phan et al.   HUMAN MOLECULAR GENETICS

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

(2009) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond the brain: widespread pathology in Huntington's disease

(2009) Jorien MM van der Burg et al.   LANCET NEUROLOGY

Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1

(2009) Yongjie Yang et al.   NEURON

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

(2009) Jennifer Bradford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excitotoxic Neuronal Death and the Pathogenesis of Huntington's Disease

(2008) Ana María Estrada Sánchez et al.   ARCHIVES OF MEDICAL RESEARCH

A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

(2008) Myriam Heiman et al.   CELL

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

Differential Activities of the Ubiquitin-Proteasome System in Neurons versus Glia May Account for the Preferential Accumulation of Misfolded Proteins in Neurons

(2008) S. Tydlacka et al.   JOURNAL OF NEUROSCIENCE

AAV Vector–mediated RNAi of Mutant Huntingtin Expression Is Neuroprotective in a Novel Genetic Rat Model of Huntington's Disease

(2008) Nicholas R Franich et al.   MOLECULAR THERAPY

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

(2007) Ronald L Klein et al.   MOLECULAR THERAPY