An environment-dependent transcriptional network specifies human microglia identity

Sall1 is a transcriptional regulator defining microglia identity and function

(2016) Anne Buttgereit et al.   NATURE IMMUNOLOGY

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Specification of tissue-resident macrophages during organogenesis

(2016) E. Mass et al.   SCIENCE

Microglia function during brain development: New insights from animal models

(2015) Parizad M. Bilimoria et al.   BRAIN RESEARCH

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Mouse models rarely mimic the transcriptome of human neurodegenerative diseases: A systematic bioinformatics-based critique of preclinical models

(2015) Terry C. Burns et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Roadmap for regulation

(2015) Casey E. Romanoski et al.   NATURE

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

The selection and function of cell type-specific enhancers

(2015) Sven Heinz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microglia Plasticity During Health and Disease: An Immunological Perspective

(2015) Anat Shemer et al.   TRENDS IN IMMUNOLOGY

Microglia Function in Central Nervous System Development and Plasticity

(2015) Dorothy P. Schafer et al.   Cold Spring Harbor Perspectives in Biology

Computational deconvolution of genome wide expression data from Parkinson's and Huntington's disease brain tissues using population-specific expression analysis

(2015) Alberto Capurro et al.   Frontiers in Neuroscience

Microglia as a critical player in both developmental and late-life CNS pathologies

(2014) Noël C. Derecki et al.   ACTA NEUROPATHOLOGICA

Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression

(2014) Jeanette N. McClintick et al.   ALCOHOL

Microglial dysfunction in brain aging and Alzheimer's disease

(2014) Kira Irving Mosher et al.   BIOCHEMICAL PHARMACOLOGY

Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

(2014) Yonit Lavin et al.   CELL

Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

(2014) David Gosselin et al.   CELL

RNA-Seq Data Mining: Downregulation of NeuroD6 Serves as a Possible Biomarker for Alzheimer’s Disease Brains

(2014) Jun-ichi Satoh et al.   DISEASE MARKERS

Ontogeny and Functions of Central Nervous System Macrophages

(2014) Atsuko Katsumoto et al.   JOURNAL OF IMMUNOLOGY

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

(2014) Andrea Crotti et al.   NATURE NEUROSCIENCE

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

The Evolving Biology of Microglia in Alzheimer’s Disease

(2014) Tarja M. Malm et al.   Neurotherapeutics

Systems-Based Analyses of Brain Regions Functionally Impacted in Parkinson's Disease Reveals Underlying Causal Mechanisms

(2014) Brigit E. Riley et al.   PLoS One

Advanced Heat Map and Clustering Analysis Using Heatmap3

(2014) Shilin Zhao et al.   Biomed Research International

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

(2014) Charity W Law et al.   GENOME BIOLOGY

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

Microglial Dysregulation in Psychiatric Disease

(2013) Luciana Romina Frick et al.   Clinical & Developmental Immunology

The transcription factor PU.1 is critical for viability and function of human brain microglia

(2013) Amy M. Smith et al.   GLIA

Remodeling of the Enhancer Landscape during Macrophage Activation Is Coupled to Enhancer Transcription

(2013) Minna U. Kaikkonen et al.   MOLECULAR CELL

Effect of natural genetic variation on enhancer selection and function

(2013) S. Heinz et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways

(2013) Katrin Kierdorf et al.   NATURE NEUROSCIENCE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

The NHGRI GWAS Catalog, a curated resource of SNP-trait associations

(2013) Danielle Welter et al.   NUCLEIC ACIDS RESEARCH

Extensive Variation in Chromatin States Across Humans

(2013) M. Kasowski et al.   SCIENCE

Coordinated Effects of Sequence Variation on DNA Binding, Chromatin Structure, and Transcription

(2013) H. Kilpinen et al.   SCIENCE

Identification of Genetic Variants That Affect Histone Modifications in Human Cells

(2013) G. McVicker et al.   SCIENCE

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Genes and pathways underlying regional and cell type changes in Alzheimer's disease

(2013) Jeremy A Miller et al.   Genome Medicine

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

(2012) C. Schulz et al.   SCIENCE

An optimized protocol for the acute isolation of human microglia from autopsy brain samples

(2011) Marta Olah et al.   GLIA

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Significant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-1-Associated Neurocognitive Disorders

(2011) Alejandra Borjabad et al.   PLoS Pathogens

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: A multimodal imaging study

(2010) Marios Politis et al.   HUMAN BRAIN MAPPING

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Gene expression reveals overlap between normal aging and Alzheimer's disease genes

(2010) Dimitrios Avramopoulos et al.   NEUROBIOLOGY OF AGING

The Sequence Read Archive

(2010) R. Leinonen et al.   NUCLEIC ACIDS RESEARCH

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

(2009) Jennifer A. Webster et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function

(2009) P R Maycox et al.   MOLECULAR PSYCHIATRY

Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration

(2008) Alice S. Chen-Plotkin et al.   HUMAN MOLECULAR GENETICS

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS