Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis

(2019) Kristen E. Funk et al.   Journal of Neuroinflammation

Multi-sensory Gamma Stimulation Ameliorates Alzheimer’s-Associated Pathology and Improves Cognition

(2019) Anthony J. Martorell et al.   CELL

Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development

(2018) Ilia D. Vainchtein et al.   SCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke

(2018) Murielle G. Kluge et al.   NEUROSCIENCE

Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats

(2017) Fei Hao et al.   EXPERIMENTAL NEUROLOGY

The microglial fractalkine receptor is not required for activity-dependent plasticity in the mouse visual system

(2017) Rebecca L. Lowery et al.   GLIA

Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1

(2017) Rachel W. Schecter et al.   JOURNAL OF NEUROSCIENCE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex

(2017) Sinisa Hrvatin et al.   NATURE NEUROSCIENCE

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

(2016) Hansen Lui et al.   CELL

New insights on the role of microglia in synaptic pruning in health and disease

(2016) Soyon Hong et al.   CURRENT OPINION IN NEUROBIOLOGY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

A complement–microglial axis drives synapse loss during virus-induced memory impairment

(2016) Michael J. Vasek et al.   NATURE

Expansion microscopy with conventional antibodies and fluorescent proteins

(2016) Tyler J Chozinski et al.   NATURE METHODS

Single-cell barcoding and sequencing using droplet microfluidics

(2016) Rapolas Zilionis et al.   Nature Protocols

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

(2016) G. O. Sipe et al.   Nature Communications

Atf3mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury

(2016) Manuel Gey et al.   Open Biology

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

(2016) Franck Madoux et al.   Scientific Reports

Fractalkine in the nervous system: neuroprotective or neurotoxic molecule?

(2015) Clotilde Lauro et al.   Annals of the New York Academy of Sciences

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury

(2015) Francesca Viganò et al.   GLIA

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Microglia: Dynamic Mediators of Synapse Development and Plasticity

(2015) Yuwen Wu et al.   TRENDS IN IMMUNOLOGY

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior

(2014) Yang Zhan et al.   NATURE NEUROSCIENCE

Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice

(2014) Alejandra Droguett et al.   PLoS One

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Microglia, seen from the CX3CR1 angle

(2013) Yochai Wolf et al.   Frontiers in Cellular Neuroscience

Thalamocortical Dysconnectivity in Schizophrenia

(2012) Neil D. Woodward et al.   AMERICAN JOURNAL OF PSYCHIATRY

Development and critical period plasticity of the barrel cortex

(2012) Reha S. Erzurumlu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Sensory Experience Restructures Thalamocortical Axons during Adulthood

(2012) Marcel Oberlaender et al.   NEURON

Activity-Dependent Proteolytic Cleavage of Neuroligin-1

(2012) Kunimichi Suzuki et al.   NEURON

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

(2011) K.-W. Kim et al.   BLOOD

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Experience-induced plasticity of thalamocortical axons in both juveniles and adults

(2010) Verena C. Wimmer et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Classical MHCI Molecules Regulate Retinogeniculate Refinement and Limit Ocular Dominance Plasticity

(2009) Akash Datwani et al.   NEURON

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

(2008) Jessica Pruessmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY