Exploiting microRNA regulation for genetic engineering

37. Modifying Target Structure Greatly Improves the Efficiency of microRNA-Regulated Vectors

(2016)   MOLECULAR THERAPY

Hepatic miR-29ab1 expression modulates chronic hepatic injury

(2012) Takayuki Kogure et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-124 Is a Subventricular Zone Neuronal Fate Determinant

(2012) M. Akerblom et al.   JOURNAL OF NEUROSCIENCE

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

(2012) Jun Xie et al.   NATURE METHODS

High-throughput assessment of microRNA activity and function using microRNA sensor and decoy libraries

(2012) Gavriel Mullokandov et al.   NATURE METHODS

Replication in Cells of Hematopoietic Origin Is Necessary for Dengue Virus Dissemination

(2012) Alissa M. Pham et al.   PLoS Pathogens

Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

(2011) K. Sugio et al.   CLINICAL CANCER RESEARCH

Kinetic Analysis Reveals the Fate of a MicroRNA following Target Regulation in Mammalian Cells

(2011) Alessia Baccarini et al.   CURRENT BIOLOGY

MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy

(2011) N Lachmann et al.   GENE THERAPY

MicroRNA therapeutics

(2011) J A Broderick et al.   GENE THERAPY

Chemical modification and design of anti-miRNA oligonucleotides

(2011) K A Lennox et al.   GENE THERAPY

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

(2011) Janka Mátrai et al.   HEPATOLOGY

MicroRNAs and their roles in mammalian stem cells

(2011) R. Yi et al.   JOURNAL OF CELL SCIENCE

miR-146ais a significant brake on autoimmunity, myeloproliferation, and cancer in mice

(2011) Mark P. Boldin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-  Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

(2011) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Mechanisms and Consequences of Alternative Polyadenylation

(2011) Dafne Campigli Di Giammartino et al.   MOLECULAR CELL

Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants

(2011) Jr-Shiuan Yang et al.   MOLECULAR CELL

miRNA-mediated Silencing in Hepatocytes Can Increase Adaptive Immune Responses to Adenovirus Vector-delivered Transgenic Antigens

(2011) Matthias W Kron et al.   MOLECULAR THERAPY

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector Tropism

(2011) Mathias F Leber et al.   MOLECULAR THERAPY

MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy

(2011) Mina Hikichi et al.   MOLECULAR THERAPY

A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A

(2011) Hideto Matsui et al.   MOLECULAR THERAPY

Construction of an Oncolytic Herpes Simplex Virus That Precisely Targets Hepatocellular Carcinoma Cells

(2011) Xinping Fu et al.   MOLECULAR THERAPY

A resource of vectors and ES cells for targeted deletion of microRNAs in mice

(2011) Haydn M Prosser et al.   NATURE BIOTECHNOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

MicroRNAs can generate thresholds in target gene expression

(2011) Shankar Mukherji et al.   NATURE GENETICS

Evolution of microRNA diversity and regulation in animals

(2011) Eugene Berezikov   NATURE REVIEWS GENETICS

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

(2011) Eric Huntzinger et al.   NATURE REVIEWS GENETICS

MicroRNA Controlled Adenovirus Mediates Anti-Cancer Efficacy without Affecting Endogenous MicroRNA Activity

(2011) Ryan Cawood et al.   PLoS One

Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells

(2011) Huajun Jin et al.   PLoS One

Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene

(2011) Rebecca L. Skalsky et al.   PLoS One

Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

(2011) X. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA-Based System for Selecting and Maintaining the Pluripotent State in Human Induced Pluripotent Stem Cells

(2011) Bruno Di Stefano et al.   STEM CELLS

Neurovirulent flavivirus can be attenuated in mice by incorporation of neuron-specific microRNA recognition elements into viral genome

(2011) Li-Chen Yen et al.   VACCINE

Identification of RNA-protein interaction networks using PAR-CLIP

(2011) Manuel Ascano et al.   Wiley Interdisciplinary Reviews-RNA

Manipulating Immune Tolerance with Micro-RNA Regulated Gene Therapy

(2011) Kevin Scott Goudy et al.   Frontiers in Microbiology

Emerging Roles for Natural MicroRNA Sponges

(2010) Margaret S. Ebert et al.   CURRENT BIOLOGY

microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors

(2010) A Geisler et al.   GENE THERAPY

Analysis of microRNA knockouts in mice

(2010) C. Y. Park et al.   HUMAN MOLECULAR GENETICS

In Vitro and In Vivo Characterization of MicroRNA-Targeted Alphavirus Replicon and Helper RNAs

(2010) K. I. Kamrud et al.   JOURNAL OF VIROLOGY

Insertion of MicroRNA Targets into the Flavivirus Genome Alters Its Highly Neurovirulent Phenotype

(2010) B. L. Heiss et al.   JOURNAL OF VIROLOGY

Expanding the MicroRNA Targeting Code: Functional Sites with Centered Pairing

(2010) Chanseok Shin et al.   MOLECULAR CELL

Gene Therapy of Chronic Granulomatous Disease: The Engraftment Dilemma

(2010) Manuel Grez et al.   MOLECULAR THERAPY

MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression

(2010) Jun Xie et al.   MOLECULAR THERAPY

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

Rationalizing the development of live attenuated virus vaccines

(2010) Adam S Lauring et al.   NATURE BIOTECHNOLOGY

Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability

(2010) Justyna Leja et al.   PLoS One

Live Cell Monitoring of hiPSC Generation and Differentiation Using Differential Expression of Endogenous microRNAs

(2010) Masakazu Kamata et al.   PLoS One

microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus

(2010) S. T. Magill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors

(2010) R. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

Target RNA-Directed Trimming and Tailing of Small Silencing RNAs

(2010) S. L. Ameres et al.   SCIENCE

Identification of Hematopoietic Stem Cell-Specific miRNAs Enables Gene Therapy of Globoid Cell Leukodystrophy

(2010) B. Gentner et al.   Science Translational Medicine

HITS-CLIP: panoramic views of protein-RNA regulation in living cells

(2010) Robert B. Darnell   Wiley Interdisciplinary Reviews-RNA

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

(2009) F. Pucci et al.   BLOOD

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

(2009) A. Annoni et al.   BLOOD

The Centrality of RNA

(2009) Phillip A. Sharp   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

MicroRNA Regulation of Oncolytic Herpes Simplex Virus-1 for Selective Killing of Prostate Cancer Cells

(2009) C. Y. F. Lee et al.   CLINICAL CANCER RESEARCH

Attenuation of Vesicular Stomatitis Virus Encephalitis through MicroRNA Targeting

(2009) E. J. Kelly et al.   JOURNAL OF VIROLOGY

Regulated and Multiple miRNA and siRNA Delivery Into Primary Cells by a Lentiviral Platform

(2009) Mario Amendola et al.   MOLECULAR THERAPY

MicroRNA-mediated species-specific attenuation of influenza A virus

(2009) Jasmine T Perez et al.   NATURE BIOTECHNOLOGY

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Use of Tissue-Specific MicroRNA to Control Pathology of Wild-Type Adenovirus without Attenuation of Its Ability to Kill Cancer Cells

(2009) Ryan Cawood et al.   PLoS Pathogens

Harnessing Endogenous miRNAs to Control Virus Tissue Tropism as a Strategy for Developing Attenuated Virus Vaccines

(2008) Dwight Barnes et al.   Cell Host & Microbe

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Engineered lentiviral vector targeting astrocytesIn vivo

(2008) Angélique Colin et al.   GLIA

Development of a Dual-Luciferase Reporter System for In Vivo Visualization of MicroRNA Biogenesis and Posttranscriptional Regulation

(2008) J. Y. Lee et al.   JOURNAL OF NUCLEAR MEDICINE

Generation of a Conditionally Replicating Adenovirus Based on Targeted Destruction of E1A mRNA by a Cell Type-Specific MicroRNA

(2008) E. Ylosmaki et al.   JOURNAL OF VIROLOGY

miR-122a-Regulated Expression of a Suicide Gene Prevents Hepatotoxicity Without Altering Antitumor Effects in Suicide Gene Therapy

(2008) Takayuki Suzuki et al.   MOLECULAR THERAPY

A let-7 MicroRNA-sensitive Vesicular Stomatitis Virus Demonstrates Tumor-specific Replication

(2008) Robert E Edge et al.   MOLECULAR THERAPY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

MicroRNAs accurately identify cancer tissue origin

(2008) Nitzan Rosenfeld et al.   NATURE BIOTECHNOLOGY

Engineering microRNA responsiveness to decrease virus pathogenicity

(2008) Elizabeth J Kelly et al.   NATURE MEDICINE

Stable knockdown of microRNA in vivo by lentiviral vectors

(2008) Bernhard Gentner et al.   NATURE METHODS

Selective Blockade of MicroRNA Processing by Lin28

(2008) S. R. Viswanathan et al.   SCIENCE