Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution

Disruption of De Novo Serine Synthesis in Müller Cells Induced Mitochondrial Dysfunction and Aggravated Oxidative Damage

(2018) Ting Zhang et al.   MOLECULAR NEUROBIOLOGY

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Central retinal artery occlusion – rethinking retinal survival time

(2018) Stephan Tobalem et al.   BMC Ophthalmology

Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina

(2018) Susanne C. Beck et al.   Scientific Reports

Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas

(2018) Kai Yao et al.   NATURE

Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

(2018) Mark F Sabbagh et al.   eLife

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Genome-wide analyses identify common variants associated with macular telangiectasia type 2

(2017) Thomas S Scerri et al.   NATURE GENETICS

Single-cell mRNA quantification and differential analysis with Census

(2017) Xiaojie Qiu et al.   NATURE METHODS

Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome

(2017) Michele Ferrari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease

(2017) Susanne C. Beck et al.   PLoS One

Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography

(2016) Lavanya Chidambara et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis

(2016) D. Samanta et al.   CANCER RESEARCH

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

(2016) Joni Nikkanen et al.   Cell Metabolism

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

(2016) Michael E Pacold et al.   Nature Chemical Biology

Reversible Brain Abnormalities in People Without Signs of Mountain Sickness During High-Altitude Exposure

(2016) Cunxiu Fan et al.   Scientific Reports

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes

(2015) Hye Jin Hwang et al.   BIOCHEMISTRY

Recovery Potential After Acute Stroke

(2015) Rüdiger J. Seitz et al.   Frontiers in Neurology

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Familial exudative vitreoretinopathy and related retinopathies

(2014) D F Gilmour   EYE

The Role of the Hypoxia Response in Shaping Retinal Vascular * Development in the Absence of Norrin/Frizzled4 Signaling

(2014) A. Rattner et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

An EMMPRIN- -catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions

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The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling

(2013) Simran S. Sabharwal et al.   BIOCHEMICAL JOURNAL

Long-Term Adaptation of Cerebral Hemodynamic Response to Somatosensory Stimulation during Chronic Hypoxia in Awake Mice

(2013) Hiroyuki Takuwa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microvascular Sprouting, Extension, and Creation of New Capillary Connections with Adaptation of the Neighboring Astrocytes in Adult Mouse Cortex under Chronic Hypoxia

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VEGF and Notch in Tip and Stalk Cell Selection

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Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

(2012) Xia Ke et al.   CARCINOGENESIS

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Regulation of the cardiac sodium pump

(2012) W. Fuller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death

(2012) T. Hamidi et al.   CLINICAL CANCER RESEARCH

Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

(2012) Clare Howarth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2

(2012) J. de Melo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity

(2011) Daniel Tello et al.   Cell Metabolism

Pilot Application of iTRAQ to the Retinal Disease Macular Telangiectasia

(2011) Alice C. L. Len et al.   JOURNAL OF PROTEOME RESEARCH

Genome-Wide Analysis of Müller Glial Differentiation Reveals a Requirement for Notch Signaling in Postmitotic Cells to Maintain the Glial Fate

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CoGAPS: an R/C++ package to identify patterns and biological process activity in transcriptomic data

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Perifoveal Müller Cell Depletion in a Case of Macular Telangiectasia Type 2

(2010) Michael B. Powner et al.   OPHTHALMOLOGY

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

(2009) Yair Benita et al.   NUCLEIC ACIDS RESEARCH

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A model for familial exudative vitreoretinopathy caused by LPR5 mutations

(2008) C.-H. Xia et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transcriptome of retinal Müller glial cells

(2008) Karin Roesch et al.   JOURNAL OF COMPARATIVE NEUROLOGY