The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity

Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity

(2019) Allison Padegimas et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

(2019) Garrison Dyck et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cardioprotective roles of Sestrin1 and Sestrin2 against doxorubicin cardiotoxicity

(2019) Ruiting Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

AMPK activation inhibits the functions of myeloid-derived suppressor cells (MDSC): impact on cancer and aging

(2019) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Metformin promotes autophagy in ischemia/reperfusion myocardium via cytoplasmic AMPKα1 and nuclear AMPKα2 pathways

(2019) Yishi Wang et al.   LIFE SCIENCES

Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes

(2019) Poliana Camila Marinello et al.   Scientific Reports

Sex differences in anthracycline-induced cardiotoxicity: the benefits of estrogens

(2019) Christian Cadeddu Dessalvi et al.   HEART FAILURE REVIEWS

Endurance Exercise Attenuates Doxorubicin-induced Cardiotoxicity

(2019) Youngil Lee et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Synthesis and structure–activity relationships of pyrazolo‐[3,4‐ b ]pyridine derivatives as adenosine 5'‐monophosphate‐activated protein kinase activators

(2019) Bifeng Zheng et al.   ARCHIV DER PHARMAZIE

IMM-H007 improves heart function via reducing cardiac fibrosis

(2019) Weipeng Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A phase I delayed-start, randomized and pharmacodynamic study of metformin and chemotherapy in patients with solid tumors

(2019) Mohammad Wasif Saif et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Cardiovascular Toxicities in Pediatric Cancer Survivors

(2019) Thomas D. Ryan et al.   CARDIOLOGY CLINICS

Promise and challenges for direct small molecule AMPK activators

(2018) Séverine Olivier et al.   BIOCHEMICAL PHARMACOLOGY

Resveratrol suppresses doxorubicin-induced cardiotoxicity by disrupting E2F1 mediated autophagy inhibition and apoptosis promotion

(2018) Jun Gu et al.   BIOCHEMICAL PHARMACOLOGY

AMPK blunts chronic heart failure by inhibiting autophagy

(2018) Yanhui Li et al.   BIOSCIENCE REPORTS

New Insights Into the Role of mTOR Signaling in the Cardiovascular System

(2018) Sebastiano Sciarretta et al.   CIRCULATION RESEARCH

A novel compound DT-010 protects against doxorubicin-induced cardiotoxicity in zebrafish and H9c2 cells by inhibiting reactive oxygen species-mediated apoptotic and autophagic pathways

(2018) Fan Tang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transient activation of AMPK preceding left ventricular pressure overload reduces adverse remodeling and preserves left ventricular function

(2018) Deok Hwa Nam et al.   FASEB JOURNAL

The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: The Role of Autophagy

(2018) Rita Zilinyi et al.   MOLECULES

AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis

(2018) Dong Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic Effects of Metformin in the Failing Heart

(2018) Aleksandra Dziubak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical and preclinical evidence of sex-related differences in anthracycline-induced cardiotoxicity

(2018) Becky Meiners et al.   Biology of Sex Differences

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat

(2018) Chih-Chao Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

AMPK: a therapeutic target of heart failure—not only metabolism regulation

(2018) Xuan Li et al.   BIOSCIENCE REPORTS

Dapagliflozin Attenuates Na+/H+ Exchanger-1 in Cardiofibroblasts via AMPK Activation

(2018) Yumei Ye et al.   CARDIOVASCULAR DRUGS AND THERAPY

Still sour about lactic acidosis years later: role of metformin in heart failure

(2017) William Kuan et al.   HEART FAILURE REVIEWS

Enhanced-autophagy by exenatide mitigates doxorubicin-induced cardiotoxicity

(2017) Kyung Hye Lee et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Protective effects of acute exercise prior to doxorubicin on cardiac function of breast cancer patients: A proof-of-concept RCT

(2017) A.A. Kirkham et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis

(2017) Hadi Khalil et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagic dysregulation in doxorubicin cardiomyopathy

(2017) Jordan J. Bartlett et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling

(2017) Rabia Johnson et al.   MOLECULES

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Liraglutide ameliorates cardiotoxicity induced by doxorubicin in rats through the Akt/GSK-3β signaling pathway

(2017) Noha A. T. Abbas et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Cardioprotective effects of fibroblast growth factor 21 against doxorubicin-induced toxicity via the SIRT1/LKB1/AMPK pathway

(2017) Shudong Wang et al.   Cell Death & Disease

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

(2017) Danqing Feng et al.   ACS Medicinal Chemistry Letters

Resveratrol-Induced AMP-Activated Protein Kinase Activation Is Cell-Type Dependent: Lessons from Basic Research for Clinical Application

(2017) Fan Lan et al.   Nutrients

Management of Heart Failure in Cancer Patients and Cancer Survivors

(2017) Jose Emanuel Finet   Heart Failure Clinics

Doxorubicin toxicity changes myocardial energy metabolism in rats

(2016) Rong Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME®trial

(2016) David Fitchett et al.   EUROPEAN HEART JOURNAL

Resveratrol-induced autophagy promotes survival and attenuates doxorubicin-induced cardiotoxicity

(2016) Jun Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT1 activation attenuates diastolic dysfunction by reducing cardiac fibrosis in a model of anthracycline cardiomyopathy

(2016) Donato Cappetta et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Resveratrol alleviate hypoxic pulmonary hypertension via anti-inflammation and anti-oxidant pathways in rats

(2016) Dunquan Xu et al.   International Journal of Medical Sciences

AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation

(2016) Evangelos P. Daskalopoulos et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia

(2016) Jun Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Aerobic Exercise Training as a Potential Cardioprotective Strategy to Attenuate Doxorubicin-Induced Cardiotoxicity

(2016) Samir A. Kouzi et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes

(2016) Mi-Hua Liu et al.   Experimental and Therapeutic Medicine

Drug-induced mitochondrial dysfunction and cardiotoxicity

(2015) Zoltán V Varga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes

(2015) Giselle Barreto-Torres et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Metformin-Associated Lactic Acidosis

(2015) Francisco J. Pasquel et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Metformin synergizes 5-fluorouracil, epirubicin, and cyclophosphamide (FEC) combination therapy through impairing intracellular ATP production and DNA repair in breast cancer stem cells

(2015) Jaslyn Sian-Siu Soo et al.   APOPTOSIS

Understanding of real alternative redox partner of Streptomyces peucetius DoxA: Prediction and validation using in silico and in vitro analyses

(2015) Hemraj Rimal et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

(2015) Yang Ruan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy

(2015) D. Cardinale et al.   CIRCULATION

Toxicity of a novel therapeutic agent targeting mitochondrial complex I

(2015) CC Low Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Resveratrol, a polyphenol phytoalexin, protects against doxorubicin-induced cardiotoxicity

(2015) Jun Gu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

New synthetic AICAR derivatives with enhanced AMPK and ACC activation

(2015) Olga Scudiero et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Resveratrol protects cardiomyocytes from doxorubicin-induced apoptosis through the AMPK/P53 pathway

(2015) MI-HUA LIU et al.   Molecular Medicine Reports

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chronic heart damage following doxorubicin treatment is alleviated by lovastatin

(2015) Christian Henninger et al.   PHARMACOLOGICAL RESEARCH

Stimulating basal mitochondrial respiration decreases doxorubicin apoptotic signaling in H9c2 cardiomyoblasts

(2015) Cláudia M. Deus et al.   TOXICOLOGY

Is AMPK the savior of the failing heart?

(2015) Ty T. Kim et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

(2014) Aurélie D. Timmermans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Ghrelin inhibits doxorubicin cardiotoxicity by inhibiting excessive autophagy through AMPK and p38-MAPK

(2014) Xue Wang et al.   BIOCHEMICAL PHARMACOLOGY

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice

(2014) Hayley M. O’Neill et al.   DIABETOLOGIA

AMP-activated Protein Kinase α2 and E2F1 Transcription Factor Mediate Doxorubicin-induced Cytotoxicity by Forming a Positive Signal Loop in Mouse Embryonic Fibroblasts and Non-carcinoma Cells

(2014) Wookyeom Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

(2014) Ioanna Andreadou et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats

(2014) Manar Hamed Arafa et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Anthracycline-induced cardiotoxicity: Overview of studies examining the roles of oxidative stress and free cellular iron

(2014) Tomáš Šimůnek et al.   Pharmacological Reports

Metformin Impairs Mitochondrial Function in Skeletal Muscle of Both Lean and Diabetic Rats in a Dose-Dependent Manner

(2014) Bart Wessels et al.   PLoS One

Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

(2014) Laura C. Kobashigawa et al.   PLoS One

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice

(2013) Ramanjaneyulu SVVS et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

(2013) Filipa S. Carvalho et al.   MEDICINAL RESEARCH REVIEWS

Oxidative Stress, Redox Signaling, and Metal Chelation in Anthracycline Cardiotoxicity and Pharmacological Cardioprotection

(2012) Martin Štěrba et al.   ANTIOXIDANTS & REDOX SIGNALING

Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study

(2012) Eric Van Den Neste et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress

(2012) Séverine Gratia et al.   CARDIOVASCULAR RESEARCH

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

(2012) Shaobin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decline in the Use of Anthracyclines for Breast Cancer

(2012) Sharon H. Giordano et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of Statin Therapy on the Risk for Incident Heart Failure in Patients With Breast Cancer Receiving Anthracycline Chemotherapy

(2012) Sinziana Seicean et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

(2012) Sui Zhang et al.   NATURE MEDICINE

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

(2012) S. A. Hawley et al.   SCIENCE

Cardioprotective effects of rosuvastatin and carvedilol on delayed cardiotoxicity of doxorubicin in rats

(2012) Yong-Hyun Kim et al.   TOXICOLOGY MECHANISMS AND METHODS

AMPK in myocardial infarction and diabetes: the yin/yang effect

(2012) Amr Moussa et al.   Acta Pharmaceutica Sinica B

Activation of AMP-Activated Protein Kinase Contributes to Doxorubicin-Induced Cell Death and Apoptosis in Cultured Myocardial H9c2 Cells

(2011) Min-Bin Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study

(2011) J. G. Boyle et al.   DIABETOLOGIA

Metformin protects against doxorubicin-induced cardiotoxicity: Involvement of the adiponectin cardiac system

(2011) Mari C. Asensio-López et al.   FREE RADICAL BIOLOGY AND MEDICINE

Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

(2011) Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small molecule AMPK activator protects the heart against ischemia–reperfusion injury

(2011) Agnes S. Kim et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity

(2011) J Huelsenbeck et al.   Cell Death & Disease

Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds

(2011) OMAR S. EL-MASRY et al.   Oncology Letters

Mitochondrial amplification selectively increases doxorubicin sensitivity in breast cancer cells with acquired antiestrogen resistance

(2010) Andrew Skildum et al.   BREAST CANCER RESEARCH AND TREATMENT

Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation

(2010) Masanori Konishi et al.   CARDIOVASCULAR RESEARCH

Metformin attenuates cardiac fibrosis by inhibiting the TGFβ1–Smad3 signalling pathway

(2010) Han Xiao et al.   CARDIOVASCULAR RESEARCH

Ppm1E is an in cellulo AMP-activated protein kinase phosphatase

(2010) Martin Voss et al.   CELLULAR SIGNALLING

Pharmacokinetic evaluation of doxorubicin plasma levels in normal and overweight patients with breast cancer and simulation of dose adjustment by different indexes of body mass

(2010) Deise Raquel Barpe et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Life-long caloric restriction elicits pronounced protection of the aged myocardium: A role for AMPK

(2010) Andrew G. Edwards et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

(2010) Amy V. Pointon et al.   PLoS One

Pretreatment with Statin Attenuates the Cardiotoxicity of Doxorubicin in Mice

(2009) A. Riad et al.   CANCER RESEARCH

AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease

(2009) Aaron K. F. Wong et al.   CLINICAL SCIENCE

Regulation of Rac1 by Simvastatin in Endothelial Cells

(2009) Ruqin Kou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

(2009) Masashi Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Activation of AMP-Activated Protein Kinase by Metformin Improves Left Ventricular Function and Survival in Heart Failure

(2008) Susheel Gundewar et al.   CIRCULATION RESEARCH

Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients

(2008) H. Boon et al.   DIABETOLOGIA

Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

(2008) Bruno Guigas et al.   IUBMB LIFE

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

(2008) Fan Lan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reactive Nitrogen Species Is Required for the Activation of the AMP-activated Protein Kinase by Statinin Vivo

(2008) Hyoung Chul Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart

(2008) Edward J. Miller et al.   NATURE