Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

AMPK and SIRT1: a long-standing partnership?

(2010) Neil B. Ruderman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes

(2010) Malgorzata Tokarska-Schlattner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

(2010) Izhak Kehat et al.   Annals of the New York Academy of Sciences

Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AMPK up-regulation

(2010) Masanori Konishi et al.   CARDIOVASCULAR RESEARCH

AMPK inhibition in health and disease

(2010) Benoit Viollet et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response

(2010) Keng Po Lai et al.   EMBO JOURNAL

Protection from Doxorubicin-Induced Cardiomyopathy Using the Modified Anthracycline N-Benzyladriamycin-14-valerate (AD 198)

(2010) C. Cai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage

(2010) A Vichalkovski et al.   ONCOGENE

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

(2009) R. J. Shaw   Acta Physiologica

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

(2009) Vernon W. Dolinsky et al.   CIRCULATION

PIKKing on PKB: regulation of PKB activity by phosphorylation

(2009) Lana Bozulic et al.   CURRENT OPINION IN CELL BIOLOGY

Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

(2009) Elizabeth D. Brookins Danz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcription Factor GATA4 Inhibits Doxorubicin-induced Autophagy and Cardiomyocyte Death

(2009) Satoru Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling of the LKB1-AMPKα Energy Sensor Pathway by Growth Factors and Oncogenic BRAFV600E

(2009) Rosaura Esteve-Puig et al.   PLoS One

Inhibitory crosstalk between ERK and AMPK in the growth and proliferation of cardiac fibroblasts

(2008) Jianhai Du et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway

(2008) Wuqiang Zhu et al.   CIRCULATION

Anthracycline Cardiotoxicity: From Bench to Bedside

(2008) Luca Gianni et al.   JOURNAL OF CLINICAL ONCOLOGY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

AMPK and Raptor: Matching Cell Growth to Energy Supply

(2008) D. Grahame Hardie   MOLECULAR CELL

High fat diet-fed obese rats are highly sensitive to doxorubicin-induced cardiotoxicity

(2008) M MITRA et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA

(2007) Chiara Guidi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS