Article
Plant Sciences
Xiaoqi Li, Xin Wang, Binyu Wang, Weiqun Chi, Zhangyi Li, Min Zhang, Yifu Shen, Xu Liu, Youmei Lu, Yu Liu
Summary: The study evaluated the protective effect of DHM on DOX-induced cardiotoxicity in vivo and in vitro. The results showed that DHM pretreatment significantly alleviated DOX-induced cardiotoxicity.
Article
Food Science & Technology
GuoYan Wang, Lei Chen, SenLin Qin, HuiJun Geng, Chao Xia, YiNing Zheng, XinJian Lei, Jun Zhang, ShengRu Wu, JunHu Yao, Lu Deng
Summary: This study reveals that chenodeoxycholic acid (CDCA) and farnesoid X receptor (FXR) can activate the mTORC1 pathway, promote lysosomal translocation and activation of mTORC1, and inhibit cellular autophagy. It suggests that decreasing SESN2 expression and activating the mTORC1 pathway could be potential therapeutic targets for enterohepatic and metabolic disorders.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yong Wang, Xiaoguang Lu, Xiaoping Wang, Qi Qiu, Ping Zhu, Lin Ma, Xiao Ma, Joerg Herrmann, Xueying Lin, Wei Wang, Xiaolei Xu
Summary: The study aimed to elucidate the dynamic autophagic defects in AIC and identify a mechanism-based therapy through genetic and pharmacological studies. Results showed that atg7-based autophagy activation is an effective therapeutic avenue to reverse the decline in cardiac function in AIC, highlighting the time-dependent nature of autophagy-based therapy.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xiaoguang Lu, Linghui Lu, Li Gao, Yong Wang, Wei Wang
Summary: Anthracyclines are effective chemotherapeutics for cancer treatment, but they can lead to cardiotoxicity. Calycosin (CA) extracted from traditional Chinese medicine Astragalus may reverse chronic anthracycline-induced cardiotoxicity by modulating autophagy. Further research is needed to understand the mechanism of CA regulation of autophagy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Zhengzhu Sun, Chongfeng Fang, Shasha Xu, Bin Wang, Danlei Li, Xiaoman Liu, Yafei Mi, Hangyuan Guo, Jianjun Jiang
Summary: SIRT3 effectively attenuates DOX-induced cardiotoxicity by inhibiting NLRP3 inflammasome activation and regulating autophagy. This finding provides a theoretical foundation for further exploration of cardiac toxicity.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Manrose Singh, Akito T. Nicol, Jaclyn DelPozzo, Jia Wei, Mandeep Singh, Tony Nguyen, Satoru Kobayashi, Qiangrong Liang
Summary: Current research suggests that metformin (MET) may reduce the cardiotoxicity of doxorubicin (DOX) and enhance its anticancer effects through the activation of AMP-activated protein kinase (AMPK). However, further studies are needed to fully understand the role and mechanism of the MET-AMPK axis in DOX cardiotoxicity and antitumor efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Xiaofan Yang, Pingping Xue, Meng Yuan, Xiang Xu, Cheng Wang, Wenqing Li, Hans-Guenther Machens, Zhenbing Chen
Summary: The study showed that after denervation of skeletal muscles, the stress-induced protein SESN2 was induced to regulate endoplasmic reticulum stress, mitochondrial dysfunction, and apoptosis, and its increase can protect against severe atrophy by inhibiting protein synthesis and promoting mitophagy.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Zuoquan Zhong, Yefei Gao, Jiedong Zhou, Fang Wang, Peipei Zhang, Songqing Hu, Haowei Wu, Haifei Lou, Jufang Chi, Hui Lin, Hangyuan Guo
Summary: In this study, we found that miR-34a-5p was upregulated in the heart after DOX treatment and inhibiting miR-34a-5p reduced autophagy and pyroptosis in DIC. We also found that inhibiting miR-34a-5p suppressed pyroptosis by regulating autophagy and reducing mitochondrial reactive oxygen species. Moreover, Sirtuin3 (Sirt3) was identified as a target gene of miR-34a-5p.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Siqi Zhang, Yixin Fan, Binbin Zheng, Yu Wang, Chen Miao, Yue Su, Kun Li, Yan E, Xueli Wang, Xueming He, Xuefeng Wu, Chenjie Xu, Yulin Tang, Wen-Tao Liu, Xiangqing Kong, Liang Hu
Summary: This study demonstrates that bilirubin has a potential protective effect against doxorubicin-induced cardiotoxicity. By activating the AMPK-Axl-SOCS3 signaling axis, bilirubin upregulates gap junction function, thereby attenuating doxorubicin-induced arrhythmia and myocardial damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ling He, Jihong Wang, Yuting Yang, Pengtao Zou, Zirong Xia, Juxiang Li
Summary: This study found that SIRT4 overexpression could protect against DOX-induced cardiotoxicity by inhibiting Akt/mTOR-dependent autophagy. These findings may provide a potential therapeutic target for DIC.
Article
Pharmacology & Pharmacy
Xiaofan Sun, Heng Meng, Jia Xiao, Fangshu Liu, Juan Du, Hui Zeng
Summary: Anthracycline antineoplastics have effective roles in treating hematological malignancies and solid tumors. However, their use as chemotherapeutic agents is limited by the cardiotoxicity they induce. This study found that inhibiting early stage of autophagy can alleviate the anthracycline-induced cardiotoxicity. Furthermore, the early autophagy inhibitor 3-MA protected cardiomyocyte cells from anthracycline-induced cardiotoxicity in vitro and in a chronic cardiotoxicity mouse model.
Review
Cell Biology
Xue Yu, Yan Yang, Tianzuo Chen, Yuqin Wang, Tianwei Guo, Yujun Liu, Hong Li, Liming Yang
Summary: Homeostatic regulation of cardiomyocytes is crucial for normal cardiac function. New cancer therapies have improved patient survival but can cause serious cardiac adverse effects. Mitochondrial targeting is a major mechanism of chemotherapy-induced cardiotoxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Xiaofan Sun, Juan Du, Heng Meng, Fangshu Liu, Nianhui Yang, Suqi Deng, Heng Wan, Dewei Ye, Erfei Song, Hui Zeng
Summary: The combination of the autophagy inhibitor SAR405 and dexrazoxane (DEX) can protect cells against anthracycline-induced cardiotoxicity. This study suggests that inhibition of autophagy at its early phase with SAR405 combined with DEX represents an effective therapeutic strategy to prevent anthracycline-induced cardiotoxicity.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Plant Sciences
Dawei Liu, Lei Zhao
Summary: This study aimed to investigate the effects of spinacetin on doxorubicin-induced cardiotoxicity and found that spinacetin can protect cardiomyocytes from damage by activating autophagy pathways.
Article
Medicine, Research & Experimental
Dawei Liu, Lei Zhao
Summary: Our study found that pretreatment with TQ can reduce Dox-induced cardiomyocyte death and apoptosis. TQ also upregulates autophagy through activation of the LKB1/AMPK pathways, further enhancing the protective effect against Dox toxicity in cardiomyocytes.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)