Doxorubicin-Induced Cardiotoxicity: From Bioenergetic Failure and Cell Death to Cardiomyopathy

Inhibition of AMPK signalling by doxorubicin: at the crossroads of the cardiac responses to energetic, oxidative, and genotoxic stress

(2012) Séverine Gratia et al.   CARDIOVASCULAR RESEARCH

Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes

(2012) Tomonori Kawaguchi et al.   CARDIOVASCULAR RESEARCH

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Effects of doxorubicin cancer therapy on autophagy and the ubiquitin-proteasome system in long-term cultured adult rat cardiomyocytes

(2012) Polychronis Dimitrakis et al.   CELL AND TISSUE RESEARCH

Carnitine and Acylcarnitines

(2012) Stephanie E. Reuter et al.   CLINICAL PHARMACOKINETICS

The Neglected Significance of “Antioxidative Stress”

(2012) B. Poljsak et al.   Oxidative Medicine and Cellular Longevity

Mitochondrionopathy Phenotype in Doxorubicin-Treated Wistar Rats Depends on Treatment Protocol and Is Cardiac-Specific

(2012) Gonçalo C. Pereira et al.   PLoS One

Changes in mitochondrial redox state, membrane potential and calcium precede mitochondrial dysfunction in doxorubicin-induced cell death

(2011) Andrey V. Kuznetsov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux

(2011) Xuguang Zhang et al.   CANCER LETTERS

Mitochondrial permeability transition in Ca2+-dependent apoptosis and necrosis

(2011) Andrea Rasola et al.   CELL CALCIUM

Drug-induced Cardiac Mitochondrial Toxicity and Protection: From Doxorubicin to Carvedilol

(2011) Goncalo C. Pereira et al.   CURRENT PHARMACEUTICAL DESIGN

Exercise as a beneficial adjunct therapy during Doxorubicin treatment—Role of mitochondria in cardioprotection

(2011) António Ascensão et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms

(2011) Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Stress and Myocardial Gene Alterations Associated with Doxorubicin-Induced Cardiotoxicity in Rats Persist for 2 Months after Treatment Cessation

(2011) C. Richard et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

p53 Regulates Oxidative Stress-Mediated Retrograde Signaling: A Novel Mechanism for Chemotherapy-Induced Cardiac Injury

(2011) Joyce M. Velez et al.   PLoS One

Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes

(2011) Tiam Feridooni et al.   PLoS One

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes

(2010) Malgorzata Tokarska-Schlattner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sub-chronic administration of doxorubicin to Wistar rats results in oxidative stress and unaltered apoptotic signaling in the lung

(2010) Nuno G. Machado et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Acute exercise protects against calcium-induced cardiac mitochondrial permeability transition pore opening in doxorubicin-treated rats

(2010) António Ascensão et al.   CLINICAL SCIENCE

Inhibition of gene expression of heart fatty acid binding protein and organic cation/carnitine transporter in doxorubicin cardiomyopathic rat model

(2010) Mohamed M. Sayed-Ahmed et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cysteine/cystine redox signaling in cardiovascular disease

(2010) Young-Mi Go et al.   FREE RADICAL BIOLOGY AND MEDICINE

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

(2010) Rui A. Carvalho et al.   TOXICOLOGY

Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro

(2009) Partha Mukhopadhyay et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2

(2009) Paolo Spallarossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The mitochondrial permeability transition pore and ischemia-reperfusion injury

(2009) Christopher P. Baines   BASIC RESEARCH IN CARDIOLOGY

The role of the mitochondrial permeability transition pore in heart disease

(2009) Andrew P. Halestrap et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Doxorubicin Inactivates Myocardial Cytochrome c Oxidase in Rats: Cardioprotection by Mito-Q

(2009) Karunakaran Chandran et al.   BIOPHYSICAL JOURNAL

Doxorubicin-induced mitochondrial dysfunction is secondary to nuclear p53 activation in H9c2 cardiomyoblasts

(2009) Vilma A. Sardão et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Glutamine regulation of doxorubicin accumulation in hearts versus tumors in experimental rats

(2009) Valentina K. Todorova et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Pathology of late-onset anthracycline cardiomyopathy

(2009) Bob N. Bernaba et al.   CARDIOVASCULAR PATHOLOGY

Respiratory chain deficiency precedes the disrupted calcium homeostasis in chronic doxorubicin cardiomyopathy

(2009) Dirk Lebrecht et al.   CARDIOVASCULAR PATHOLOGY

Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function

(2009) Antonella De Angelis et al.   CIRCULATION

Doxorubicin: The Good, the Bad and the Ugly Effect

(2009) Cristina Carvalho et al.   CURRENT MEDICINAL CHEMISTRY

The molecular composition of the mitochondrial permeability transition pore

(2009) Christopher P. Baines   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

(2009) Masashi Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Oral Glutamine Protects against Acute Doxorubicin-Induced Cardiotoxicity of Tumor-Bearing Rats

(2009) Valentina K. Todorova et al.   JOURNAL OF NUTRITION

Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases

(2009) S. Javadov et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein

(2009) Ioanna Andreadou et al.   NMR IN BIOMEDICINE

Induction of premature senescence in cardiomyocytes by doxorubicin as a novel mechanism of myocardial damage

(2008) Yasuhiro Maejima et al.   AGING CELL

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes

(2008) Jiahao Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitochondrial DNA is a direct target of anti-cancer anthracycline drugs

(2008) Neil Ashley et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Morphological alterations induced by doxorubicin on H9c2 myoblasts: nuclear, mitochondrial, and cytoskeletal targets

(2008) Vilma A. Sardão et al.   CELL BIOLOGY AND TOXICOLOGY

Acute Doxorubicin Cardiotoxicity Is Associated With p53-Induced Inhibition of the Mammalian Target of Rapamycin Pathway

(2008) Wuqiang Zhu et al.   CIRCULATION

Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity

(2008) Guo-Chang Fan et al.   CIRCULATION RESEARCH

Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

(2008) Susana Cardoso et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acute Exercise Protects Against Doxorubicin Cardiotoxicity

(2008) Karen Y. Wonders et al.   INTEGRATIVE CANCER THERAPIES

Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure

(2008) Lihe Lu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition

(2008) Anna W. C. Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Mouse Model for Juvenile Doxorubicin-Induced Cardiac Dysfunction

(2008) Wuqiang Zhu et al.   PEDIATRIC RESEARCH

Beneficial Effects of Exercise on Muscle Mitochondrial Function in Diabetes Mellitus

(2008) José A Lumini et al.   SPORTS MEDICINE