Article
Biochemistry & Molecular Biology
Hai-Han Liao, Wen Ding, Nan Zhang, Zi-Ying Zhou, Zheng Ling, Wen-Jing Li, Si Chen, Qi-Zhu Tang
Summary: This study demonstrates that AMPKa2 can inhibit ferroptosis in doxorubicin-treated hearts through regulating lipid metabolism, independent of mTORC1 or autophagy dependent pathway. Metformin can improve cardiac function by activating AMPKa2 phosphorylation and inhibiting ferroptosis in doxorubicin-treated hearts.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Tianjiao Ma, Lei Yang, Binmei Zhang, Xin Lv, Feifei Gong, Wei Yang
Summary: The purpose of this study was to investigate the protective effect of hydrogen inhalation on chronic myocardial injury induced by doxorubicin and its effect and mechanism on autophagy. The results confirmed that hydrogen inhalation can improve cardiac function decline and pathological structural abnormalities induced by doxorubicin, activate autophagy through the AMPK/mTOR pathway, and protect against myocardial injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Physiology
Xiu-ying Luo, Ze Zhong, Ai-guo Chong, Wei-wei Zhang, Xin-dong Wu
Summary: The study revealed that trimetazidine (TMZ) can inhibit myocardial apoptosis and energy metabolism disorder induced by myocardial infarction (MI) by activating the SIRT1-AMPK pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fan Qiu, Yi Yuan, Wei Luo, Yan-shan Gong, Zhong-ming Zhang, Zhong-min Liu, Ling Gao
Summary: Asiatic acid (AA), a pentacyclic triterpene derived from Centella asiatica, exhibits anti-inflammatory, antioxidant, and antiapoptotic properties. Study shows that AA protects ischemic cardiomyocytes by modulating glycophagy and mitophagy-based energy metabolism through activation of PI3K/Akt and AMPK pathways, leading to improvements in cardiac function.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Environmental Sciences
Sara Asaad Abdulkareem Aljumaily, Mehmet Demir, Hulya Elbe, Gurkan Yigitturk, Yasemin Bicer, Eyup Altinoz
Summary: The study aimed to investigate the effects of crocin on doxorubicin-induced cardiotoxicity in rats. Results showed that crocin significantly ameliorated lipid profile, cardiac markers, and oxidative stress indices caused by DOX. Additionally, crocin alleviated histopathological damage in myocardium induced by DOX.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Xiaoying Zhang, Zhiying Zhang, Pengxiang Wang, Yiwei Han, Lijun Liu, Jie Li, Yichun Chen, Duxia Liu, Jinying Wang, Xiaoying Tian, Qin Zhao, Fengxia Yan
Summary: The traditional Chinese Tibetan medicine formula BCW has been shown to effectively suppress cardiac hypertrophy by activating the AMPK/PPAR-alpha signaling pathway, regulating glycolipid metabolism, and enhancing mitochondrial function to prevent cardiomyocyte hypertrophy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hongyang Shu, Weijian Hang, Yizhong Peng, Jiali Nie, Lujin Wu, Wenjun Zhang, Dao Wen Wang, Ning Zhou
Summary: Trimetazidine attenuates pressure overload-induced heart failure by improving myocardial mitochondrial function and glucose uptake via AMPK, providing significant cardioprotective effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ashley J. Ovens, John W. Scott, Christopher G. Langendorf, Bruce E. Kemp, Jonathan S. Oakhill, William J. Smiles
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in adaptive responses to exercise, and its post-translational modifications extensively influence its activity, subcellular localization, nutrient interactions, and protein stability. Areas for further research include novel regulatory modifications of AMPK and improving characterization of these modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Agriculture, Multidisciplinary
Ziyuan Wang, Zihui Yang, Jie Liu, Yiming Hao, Baoguo Sun, Jing Wang
Summary: Mitochondria play a crucial role in cellular metabolism, and natural bioactive components in whole grains can improve metabolic disorders by modulating mitochondrial biogenesis and energy metabolism.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tao Wang, Chuqiao Yuan, Jia Liu, Liangyan Deng, Wei Li, Junling He, Honglin Liu, Liping Qu, Jianming Wu, Wenjun Zou
Summary: This study aims to explore the energy protection effect of DXXK on cardiotoxicity induced by DOX. The results showed that DXXK can treat DOX-induced cardiotoxicity through the AMPK-mediated energy protection pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Mingsheng Zhu, Weiwei Shen, Jiemei Li, Nan Jia, Yabing Xiong, Jinhua Miao, Chao Xie, Qiyan Chen, Kunyu Shen, Ping Meng, Xiaolong Li, Qinyu Wu, Shan Zhou, Maosheng Wang, Yaozhong Kong, Lili Zhou
Summary: Aging is a risk factor for kidney injury, and energy homeostasis and mitochondria play important roles in delaying aging. AMPK, a serine/threonine kinase, regulates energy and mitochondrial homeostasis as well as autophagy. In this study, the direct AMPK activator O304 was found to protect against cellular senescence and aged-related fibrosis in the kidneys, while restoring energy metabolism, promoting autophagy, and preserving mitochondrial homeostasis. Transcriptomic sequencing confirmed that O304 induced beneficial pathways and downregulated aging-related processes. This suggests that O304 has potential as a therapeutic approach to delay kidney aging.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Zhu, Bin Li, Dongqin Chen, Ning Chen, Le Xu, Qinjin Li, Xiaodong Chen
Summary: This study investigated the role of STEAP4 in maintaining cellular homeostasis and improving oxidative stress caused by a high-fat diet in hepatocytes. The results showed that STEAP4 could alleviate oxidative stress and enhance the viability of hepatocytes. It was found to regulate insulin signaling and antioxidant pathways, as well as the communication of energy between the endoplasmic reticulum and mitochondria.
Article
Plant Sciences
Xiaoqi Li, Xin Wang, Binyu Wang, Weiqun Chi, Zhangyi Li, Min Zhang, Yifu Shen, Xu Liu, Youmei Lu, Yu Liu
Summary: The study evaluated the protective effect of DHM on DOX-induced cardiotoxicity in vivo and in vitro. The results showed that DHM pretreatment significantly alleviated DOX-induced cardiotoxicity.
Article
Food Science & Technology
Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu
Summary: The study revealed that DBP can induce fatty liver disease by activating the PPAR alpha signaling pathway and inhibiting AMPK phosphorylation. The results indicated that DBP affects protein expression, leading to hyperlipidemia and abnormal liver function, which can be alleviated through the PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Manrose Singh, Akito T. Nicol, Jaclyn DelPozzo, Jia Wei, Mandeep Singh, Tony Nguyen, Satoru Kobayashi, Qiangrong Liang
Summary: Current research suggests that metformin (MET) may reduce the cardiotoxicity of doxorubicin (DOX) and enhance its anticancer effects through the activation of AMP-activated protein kinase (AMPK). However, further studies are needed to fully understand the role and mechanism of the MET-AMPK axis in DOX cardiotoxicity and antitumor efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Xiao-Hua Cui, Hui-Lin Wang, Rong Wu, Ping-An Yao, Ke-Zhao Wei, Jian-Ping Gao
MOLECULAR MEDICINE REPORTS
(2018)
Article
Chemistry, Analytical
Xiao-Lin Shan, Xiao-Ting Liu, Can Gong, Xu Xu
ANALYTICAL SCIENCES
(2018)
Article
Chemistry, Medicinal
Cheng Lu, Yan Yin, Fanli Meng, Yongbin Dun, Keke Pei, Chenlu Wang, Xu Xu, Fanhong Wu
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Physics, Atomic, Molecular & Chemical
Yao-Li Zhang, Can Gong, Xing-Li Pei, Yu-Liang Han, Yu-Yu Huang, Xu Xu
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2018)
Article
Chemistry, Physical
Liping Han, Tao Guo, Zhen Guo, Caifen Wang, Wei Zhang, Shailendra Shakya, Huanyu Ding, Haiyan Li, Xu Xu, Yujie Ren, Jiwen Zhang
JOURNAL OF PHYSICAL CHEMISTRY B
(2018)
Article
Oncology
Rong Wu, Ping-An Yao, Hui-Lin Wang, Yan Gao, Hai-Lun Yu, Lei Wang, Xiao-Hua Cui, Xu Xu, Jian-Ping Gao
MOLECULAR MEDICINE REPORTS
(2018)
Article
Chemistry, Medicinal
Ping-An Yao, Rong Wu, Yao-Li Zhang, Xiao-Hua Cui, Ke-Zhao Wei, Xu Xu, Jian-Ping Gao
PHARMACOGNOSY MAGAZINE
(2018)
Article
Multidisciplinary Sciences
Fei-Fei Cai, Rong Wu, Ya-Nan Song, Ai-Zhen Xiong, Xiao-Le Chen, Meng-Die Yang, Li Yang, Yuanjia Hu, Ming-Yu Sun, Shi-Bing Su
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Rong Wu, Shu Dong, Fei-Fei Cai, Xiao-Le Chen, Meng-Die Yang, Ping Liu, Shi-Bing Su
Review
Integrative & Complementary Medicine
Fei-Fei Cai, Wen-Jun Zhou, Rong Wu, Shi-Bing Su
Article
Integrative & Complementary Medicine
Rong Wu, Xiao-Yan Li, Wen-Hai Wang, Fei-Fei Cai, Xiao-Le Chen, Meng-Die Yang, Qiu-Sha Pan, Qi-Long Chen, Rong-Yao Zhou, Shi-Bing Su
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Pharmacology & Pharmacy
Ping -An Yao, Ke-Zhao Wei, Jia-Hua Feng, Xiao-Ning Liu, Xu Xu, Hong-Yan Cui, Xiao-Chen Zhang, Jian-Ping Gao
Summary: Sodium houttuyfonate can improve diabetic myocardial injury by regulating cardiac energy metabolism and increasing cardiac Ca2+-Mg2+-ATPase activity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Dan-Yang Shi, Yu Zheng, Qiang-Sheng Guo, Can Gong, Xu Xu, Jian-Ping Gao
Summary: A quantitative nuclear magnetic resonance spectroscopy method was developed to determine the total phenol and six polyphenolic components in the polyphenol extract of Cinnamomi cortex. The method showed excellent precision and reproducibility, and was successfully applied to different sources of authentic cinnamon polyphenol extracts.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Zhao Hai-Yan, Gong Can, Xu Xu
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Liu Xiao-Ting, Yu Shan, Yuan Ming, Guo Qiang-Sheng, Gong Can, Xu Xu
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)