Toxicity of a novel therapeutic agent targeting mitochondrial complex I

Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury

(2014) Aijun Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice

(2014) Kristen A. Baltgalvis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac Mitochondria and Reactive Oxygen Species Generation

(2014) Yeong-Renn Chen et al.   CIRCULATION RESEARCH

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

(2014) Anila K. Madiraju et al.   NATURE

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Intermittent Claudication: New Targets for Drug Development

(2013) Eric P. Brass   DRUGS

Metformin trims fats to restore insulin sensitivity

(2013) Reuben J Shaw   NATURE MEDICINE

AMPK Activation through Mitochondrial Regulation Results in Increased Substrate Oxidation and Improved Metabolic Parameters in Models of Diabetes

(2013) Yonchu Jenkins et al.   PLoS One

Development and validation of an ankle brachial index risk model for the prediction of cardiovascular events

(2013) FGR Fowkes et al.   European Journal of Preventive Cardiology

AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern

(2012) D. Grahame Hardie et al.   CHEMISTRY & BIOLOGY

Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation

(2012) Ian P Salt et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes

(2008) K. Suzuki et al.   AMERICAN JOURNAL OF HYPERTENSION

Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species

(2008) Romana Fato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS