Journal
TOXICOLOGY IN VITRO
Volume 48, Issue -, Pages 262-275Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tiv.2018.01.023
Keywords
In vitro toxicology; Xenobiotic safety; Hepatotoxicity; 3D cell culture models; Liver spheroids
Categories
Funding
- BBSRC industrial CASE partnership award - Syngenta Ltd. [BB/M503435/1]
- Liverpool Centre for Mathematics in Healthcare (EPSRC) [EP/N014499/1]
- Biotechnology and Biological Sciences Research Council [1511021] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N014499/1] Funding Source: researchfish
- Medical Research Council [MR/L006758/1] Funding Source: researchfish
- National Centre for the Replacement [NC/C011205/1] Funding Source: researchfish
- EPSRC [EP/N014499/1] Funding Source: UKRI
- MRC [MR/L006758/1] Funding Source: UKRI
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Xenobiotic safety assessment is an area that impacts a multitude of different industry sectors such as medicinal drugs, agrochemicals, industrial chemicals, cosmetics and environmental contaminants. As such there are a number of well-developed in vitro, in vivo and in silico approaches to evaluate their properties and potential impact on the environment and to humans. Additionally, there is the continual investment in multidisciplinary scientists to explore non-animal surrogate technologies to predict specific toxicological outcomes and to improve our understanding of the biological processes regarding the toxic potential of xenobiotics. Here we provide a concise, critical evaluation of a number of in vitro systems utilised to assess the hepatotoxic potential of xenobiotics.
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