Dietary Polyphenols: A Multifactorial Strategy to Target Alzheimer’s Disease

Icariin and Its Metabolites as Potential Protective Phytochemicals Against Alzheimer’s Disease

(2019) Cristina Angeloni et al.   Frontiers in Pharmacology

Innovative Therapy for Alzheimer’s Disease-With Focus on Biodelivery of NGF

(2019) Sumonto Mitra et al.   Frontiers in Neuroscience

Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells

(2019) Ravikanth Velagapudi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Resveratrol improves cognition and decreases amyloid plaque formation in Tg6799 mice

(2019) Yue Chen et al.   Molecular Medicine Reports

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Considerations for the Use of Polyphenols as Therapies in Neurodegenerative Diseases

(2019) Justine Renaud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quercetin and Epigallocatechin Gallate in the Prevention and Treatment of Obesity: From Molecular to Clinical Studies

(2019) Catalina Carrasco-Pozo et al.   JOURNAL OF MEDICINAL FOOD

Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease

(2019) Karolina Pierzynowska et al.   NEUROPHARMACOLOGY

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

(2019) Rocío M. de Pablos et al.   PHARMACOLOGICAL RESEARCH

The role of different SIRT1-mediated signaling pathways in toxic injury

(2019) Zhihua Ren et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Simvastatin Efficiently Reduces Levels of Alzheimer’s Amyloid Beta in Yeast

(2019) Sudip Dhakal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

(2019) Akira Nakajima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin-loaded nanoparticles: a novel therapeutic strategy in treatment of central nervous system disorders

(2019) Hanie Yavarpour-Bali et al.   International Journal of Nanomedicine

Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart

(2019) Pallavi Mishra et al.   Scientific Reports

Multi-target design strategies for the improved treatment of Alzheimer's disease

(2019) Pengfei Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mangiferin: A multipotent natural product preventing neurodegeneration in Alzheimer’s and Parkinson’s disease models

(2019) Si-Tong Feng et al.   PHARMACOLOGICAL RESEARCH

Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors

(2018) T. Squillaro et al.   BIOCHEMICAL PHARMACOLOGY

The mechanistic target of rapamycin (mTOR) and the silent mating-type information regulation 2 homolog 1 (SIRT1): oversight for neurodegenerative disorders

(2018) Kenneth Maiese   BIOCHEMICAL SOCIETY TRANSACTIONS

Flavonoids as acetylcholinesterase inhibitors: Current therapeutic standing and future prospects

(2018) Haroon Khan et al.   BIOMEDICINE & PHARMACOTHERAPY

Design and synthesis of donepezil analogues as dual AChE and BACE-1 inhibitors

(2018) Moustafa T. Gabr et al.   BIOORGANIC CHEMISTRY

Hydroxytyrosol regulates the autophagy of vascular adventitial fibroblasts through the SIRT1-mediated signaling pathway

(2018) Weirong Wang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The role of autophagy induction in the mechanism of cytoprotective effect of resveratrol

(2018) Zsófia Ulakcsai et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Autophagy during ageing - from Dr Jekyll to Mr Hyde

(2018) Thomas Wilhelm et al.   FEBS Journal

Quercetin and iron metabolism: What we know and what we need to know

(2018) Lin Xiao et al.   FOOD AND CHEMICAL TOXICOLOGY

SIRT1 reverses senescence via enhancing autophagy and attenuates oxidative stress-induced apoptosis through promoting p53 degradation

(2018) Tao Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Metal Ion Effects on Aβ and Tau Aggregation

(2018) Anne Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diet Supplementation with Hydroxytyrosol Ameliorates Brain Pathology and Restores Cognitive Functions in a Mouse Model of Amyloid-β Deposition

(2018) Pamela Nardiello et al.   JOURNAL OF ALZHEIMERS DISEASE

Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type

(2018) Simone Muniz Pacheco et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy at the synapse

(2018) Veronica Birdsall et al.   NEUROSCIENCE LETTERS

Benefit of Oleuropein Aglycone for Alzheimer’s Disease by Promoting Autophagy

(2018) Joaquín G. Cordero et al.   Oxidative Medicine and Cellular Longevity

Oleuropein Aglycone Protects against MAO-A-Induced Autophagy Impairment and Cardiomyocyte Death through Activation of TFEB

(2018) Caterina Miceli et al.   Oxidative Medicine and Cellular Longevity

Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy

(2018) Jia Zheng et al.   Frontiers in Pharmacology

Resveratrol-induced p53 activation is associated with autophagy in mouse embryonic stem cells

(2018) Irina I. Suvorova et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

(2018) Manish Putteeraj et al.   CURRENT DRUG TARGETS

Effects of Polyphenols on Thermogenesis and Mitochondrial Biogenesis

(2018) Tanila Wood dos Santos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aluminum and Alzheimer's Disease: After a Century of Controversy, Is there a Plausible Link?

(2018) Lucija Tomljenovic   JOURNAL OF ALZHEIMERS DISEASE

The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer's Disease

(2018) Gaurav Bedse et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin: A naturally occurring autophagy modulator

(2018) Abolfazl Shakeri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

(2018) Tae Woo Kim et al.   Cell Death & Disease

Luteolin Induces Apoptosis and Autophagy in Mouse Macrophage ANA-1 Cells via the Bcl-2 Pathway

(2018) Yuexia Liao et al.   Journal of Immunology Research

Brain ageing and neurodegenerative disease: The role of cellular waste management

(2018) Simona Daniele et al.   BIOCHEMICAL PHARMACOLOGY

Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer’s Disease and Brain Insulin Resistance, and Its Relation to Cancer

(2018) Mehmet Murat Koseoglu et al.   JOURNAL OF ALZHEIMERS DISEASE

Enhancing TFEB-Mediated Cellular Degradation Pathways by the mTORC1 Inhibitor Quercetin

(2018) Yi Huang et al.   Oxidative Medicine and Cellular Longevity

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

(2018) Piyoosh Sharma et al.   PROGRESS IN NEUROBIOLOGY

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Myricetin Exerts Anti-Obesity Effects through Upregulation of SIRT3 in Adipose Tissue

(2018) Seun Akindehin et al.   Nutrients

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

(2018) Jun Song et al.   Frontiers of Medicine

Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer’s disease

(2018) Sushant K. Shrivastava et al.   BIOORGANIC CHEMISTRY

A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease

(2017) Bilqees Sameem et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy

(2017) Youssef Dgachi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo pharmacological characterization of ASP8477: A novel highly selective fatty acid amide hydrolase inhibitor

(2017) Tomonari Watabiki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Luteolin as a potential preventive and therapeutic candidate for Alzheimer's disease

(2017) Youngjoo Kwon   EXPERIMENTAL GERONTOLOGY

Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules

(2017) Sayanti Brahmachari et al.   Future Medicinal Chemistry

Combining in silico and in vitro approaches to evaluate the acetylcholinesterase inhibitory profile of some commercially available flavonoids in the management of Alzheimer’s disease

(2017) Asokkumar Kuppusamy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

New Therapeutic Targets in Alzheimer's Disease

(2017) Horia Coman et al.   International Journal of Gerontology

Tetrahydrocurcumin ameliorates homocysteine-mediated mitochondrial remodeling in brain endothelial cells

(2017) Jonathan C. Vacek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

(2017) F. Sarubbo et al.   Journal of Neuroimmune Pharmacology

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

Acacetin protects against cardiac remodeling after myocardial infarction by mediating MAPK and PI3K/Akt signal pathway

(2017) Wei Chang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Proteostasis and ageing: insights from long-lived mutant mice

(2017) William A. Sands et al.   JOURNAL OF PHYSIOLOGY-LONDON

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

(2017) Petr Novak et al.   LANCET NEUROLOGY

Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine

(2017) Ming Hu et al.   MOLECULAR PHARMACEUTICS

α-Isocubebenol alleviates scopolamine-induced cognitive impairment by repressing acetylcholinesterase activity

(2017) Sung Hwa Song et al.   NEUROSCIENCE LETTERS

Targeting Free Radicals in Oxidative Stress-Related Human Diseases

(2017) Patrik Poprac et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation

(2017) Carla Nunes et al.   Food & Function

Biological functions of CDK5 and potential CDK5 targeted clinical treatments

(2017) Alison Shupp et al.   Oncotarget

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

(2017) Hoe-Yune Jung et al.   Scientific Reports

Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease

(2017) Nophar Geifman et al.   Alzheimers Research & Therapy

Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1–42-Induced Rat Model of Alzheimer’s Disease

(2017) Chenxia Sheng et al.   Biomed Research International

Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure

(2017) Zhen Liu et al.   Frontiers in Neuroscience

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

(2017) Manuel Matzinger et al.   BIOTECHNOLOGY ADVANCES

Polyphenols journey through blood-brain barrier towards neuronal protection

(2017) I. Figueira et al.   Scientific Reports

The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease

(2016) Xun-Hu Gu et al.   BEHAVIOURAL BRAIN RESEARCH

Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice

(2016) Sun Ah Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway

(2016) Shifeng Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nobiletin promotes antioxidant and anti-inflammatory responses and elicits protection against ischemic stroke in vivo

(2016) Lan Zhang et al.   BRAIN RESEARCH

Protective effects of BAY 73-6691, a selective inhibitor of phosphodiesterase 9, on amyloid-β peptides-induced oxidative stress in in-vivo and in-vitro models of Alzheimer's disease

(2016) Jian Li et al.   BRAIN RESEARCH

Oleuropein aglycone and polyphenols from olive mill waste water ameliorate cognitive deficits and neuropathology

(2016) Daniela Pantano et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations

(2016) Maricarmen Hernández-Rodríguez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment - a randomized double-blind placebo-controlled trial

(2016) Stefanie M. Beck et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Modeling the protonation states of β-secretase binding pocket by molecular dynamics simulations and docking studies

(2016) Dima A. Sabbah et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

(2016) Johannes Levin et al.   JOURNAL OF NEURAL TRANSMISSION

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Finding chemopreventatives to reduce amyloid beta in yeast

(2016) IanG Macreadie et al.   Neural Regeneration Research

Baicalein inhibits TNF-α-induced NF-κB activation and expression of NF-κB-regulated target gene products

(2016) Junbo Li et al.   ONCOLOGY REPORTS

Redox Status and Proteostasis in Ageing and Disease

(2016) Federica Rizzi et al.   Oxidative Medicine and Cellular Longevity

EGCG Inhibited Lipofuscin Formation Based on Intercepting Amyloidogenic β-Sheet-Rich Structure Conversion

(2016) Shuxian Cai et al.   PLoS One

Mushrooms do not contain flavonoids

(2016) Alicia Gil-Ramírez et al.   Journal of Functional Foods

Curcumin targets the TFEB-lysosome pathway for induction of autophagy

(2016) Jianbin Zhang et al.   Oncotarget

Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia

(2016) Jintao Bao et al.   Protein & Cell

Serotonin: A New Hope in Alzheimer’s Disease?

(2015) Sylvie Claeysen et al.   ACS Chemical Neuroscience

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)

(2015) Akira Nakajima et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis and evaluation of selegiline derivatives as monoamine oxidase inhibitor, antioxidant and metal chelator against Alzheimer’s disease

(2015) Shishun Xie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation

(2015) Adi Zheng et al.   BRITISH JOURNAL OF NUTRITION

Aβ25–35 Suppresses Mitochondrial Biogenesis in Primary Hippocampal Neurons

(2015) Weiguo Dong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Role of RAGE in Alzheimer’s Disease

(2015) Zhiyou Cai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Icariin protects SH-SY5Y cells from formaldehyde-induced injury through suppression of Tau phosphorylation

(2015) Yi-xiang Song et al.   Chinese Journal of Integrative Medicine

Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes

(2015) Sebastiano Sciarretta et al.   CLINICAL SCIENCE

Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice

(2015) Rebecca Skerrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease

(2015) Zhiren Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Tacrine–Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

(2015) Xiaoming Zha et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mangiferin ameliorates aluminium chloride-induced cognitive dysfunction via alleviation of hippocampal oxido-nitrosative stress, proinflammatory cytokines and acetylcholinesterase level

(2015) Prajapati Kasbe et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The Role of Cdk5 in Alzheimer’s Disease

(2015) Shu-Lei Liu et al.   MOLECULAR NEUROBIOLOGY

Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

(2015) Susmita Kaushik et al.   NATURE CELL BIOLOGY

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing

(2015) Carla J. Cox et al.   NEUROBIOLOGY OF AGING

Bioavailability of dietary polyphenols: Factors contributing to their clinical application in CNS diseases

(2015) M.D. Pandareesh et al.   NEUROCHEMISTRY INTERNATIONAL

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice

(2015) F. Li et al.   NEUROSCIENCE

Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization

(2015) Marvin M. Hansen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

(2015) Harindranath Kadavath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural products—friends or foes?

(2015) Denisa Margină et al.   TOXICOLOGY LETTERS

Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells

(2015) Alberto Valdés et al.   Journal of Functional Foods

Novel Fluorinated 8-Hydroxyquinoline Based Metal Ionophores for Exploring the Metal Hypothesis of Alzheimer’s Disease

(2015) Steven H. Liang et al.   ACS Medicinal Chemistry Letters

Serotonin 6 receptor controls alzheimer’s disease and depression

(2015) Hyung-Mun Yun et al.   Oncotarget

Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight

(2015) Stefania Rigacci et al.   Oncotarget

Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer’s disease

(2015) Xue Wang et al.   Scientific Reports

Oxidative stress - a key emerging impact factor in health, ageing, lifestyle and aesthetics

(2015) K. Kandola et al.   INTERNATIONAL JOURNAL OF COSMETIC SCIENCE

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

(2014) Daniel M. Michaelson   Alzheimers & Dementia

Multitarget Drug Discovery for Alzheimer's Disease: Triazinones as BACE-1 and GSK-3β Inhibitors

(2014) Federica Prati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyphenols and mitochondria: An update on their increasingly emerging ROS-scavenging independent actions

(2014) Cristian Sandoval-Acuña et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-β25–35 in rat cortical neurons

(2014) Qinru Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of triazines as selective PDE4B versus PDE4D inhibitors

(2014) Timothy J. Hagen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Icariin-Mediated Inhibition of NF-κB Activity Enhances the In Vitro and In Vivo Antitumour Effect of 5-Fluorouracil in Colorectal Cancer

(2014) De-Bing Shi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Anthocyanins Protect against Kainic Acid-induced Excitotoxicity and Apoptosis via ROS-activated AMPK Pathway in Hippocampal Neurons

(2014) Ikram Ullah et al.   CNS Neuroscience & Therapeutics

Dietary Polyphenols and Type 2 Diabetes: Current Insights and Future Perspectives

(2014) J.B. Xiao et al.   CURRENT MEDICINAL CHEMISTRY

Emerging Targets in Neurodegeneration: New Opportunities for Alzheimer's Disease Treatment?

(2014) Angela Rampa et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The green tea polyphenol (−)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios

(2014) Heike J. Wobst et al.   FEBS LETTERS

Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

(2014) Irundika H.K. Dias et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular insight into the interaction mechanisms of amino-2H-imidazole derivatives with BACE1 protease: A QM/MM and QTAIM study

(2014) Esteban Gabriel Vega-Hissi et al.   INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY

The Phytoestrogen Genistein Modulates Lysosomal Metabolism and Transcription Factor EB (TFEB) Activation

(2014) Marta Moskot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

(2014) Luiza M.F. Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Decreased γ-aminobutyric acid levels in the parietal region of patients with Alzheimer's disease

(2014) Xue Bai et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Protective Mechanisms of Acacetin against d-Galactosamine and Lipopolysaccharide-Induced Fulminant Hepatic Failure in Mice

(2014) Hong-Ik Cho et al.   JOURNAL OF NATURAL PRODUCTS

Extra virgin olive oil phenols down-regulate lipid synthesis in primary-cultured rat-hepatocytes

(2014) Paola Priore et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Understanding Zinc(II) Chelation with Quercetin and Luteolin: A Combined NMR and Theoretical Study

(2014) Alexandra Primikyri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates Hepatic Autophagy and Lipid Clearance

(2014) Jin Zhou et al.   PLoS One

Resveratrol encapsulation: Designing delivery systems to overcome solubility, stability and bioavailability issues

(2014) Gabriel Davidov-Pardo et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

(2014) S-Y Kook et al.   Cell Death & Disease

First-in-man tau vaccine targeting structural determinants essential for pathological tau–tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer’s disease model

(2014) Eva Kontsekova et al.   Alzheimers Research & Therapy

β-secretase inhibitor; a promising novel therapeutic drug in Alzheimer’s disease

(2014) Kelly Willemijn Menting et al.   Frontiers in Aging Neuroscience

New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate

(2014) Hae-Suk Kim et al.   Redox Biology

Autophagy in ageing and ageing-associated diseases

(2013) Li-qiang He et al.   ACTA PHARMACOLOGICA SINICA

New Insights on NOX Enzymes in the Central Nervous System

(2013) Zeynab Nayernia et al.   ANTIOXIDANTS & REDOX SIGNALING

Reactive Oxygen Species in Inflammation and Tissue Injury

(2013) Manish Mittal et al.   ANTIOXIDANTS & REDOX SIGNALING

Protective effect of curcuminoids on age-related mitochondrial impairment in female Wistar rat brain

(2013) Manisha Rastogi et al.   BIOGERONTOLOGY

Apolipoprotein E, gender, and Alzheimer’s disease: an overlooked, but potent and promising interaction

(2013) Leo Ungar et al.   Brain Imaging and Behavior

Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat

(2013) Lan Zhang et al.   BRAIN RESEARCH BULLETIN

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro

(2013) Emelie Janefjord et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Lipophilic Bullet Hits the Targets: Medicinal Chemistry of Adamantane Derivatives

(2013) Lukas Wanka et al.   CHEMICAL REVIEWS

Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells

(2013) Markus Karlsson et al.   EXPERIMENTAL EYE RESEARCH

Heat-Stable Components of Wood Ear Mushroom, Auricularia polytricha (Higher Basidiomycetes), Inhibit In Vitro Activity of Beta Secretase (BACE1)

(2013) Louise Bennett et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men

(2013) E Konings et al.   INTERNATIONAL JOURNAL OF OBESITY

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

(2013) WEN-WEN HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Green Tea Polyphenols Alleviate Obesity in Broiler Chickens through the Regulation of Lipid-Metabolism-Related Genes and Transcription Factor Expression

(2013) Jinbao Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model

(2013) She-Qing Zhang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Amyloid beta immunization worsens iron deposits in the choroid plexus and cerebral microbleeds

(2013) Nelly Joseph-Mathurin et al.   NEUROBIOLOGY OF AGING

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells

(2013) Chiao-Wen Lin et al.   PLoS One

Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-  species

(2013) S.-J. Hyung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylcholinesterase Inhibitory Activities of Flavonoids from the Leaves ofGinkgo bilobaagainst Brown Planthopper

(2013) Xiao Ding et al.   Journal of Chemistry

Autophagy, polyphenols and healthy ageing

(2012) Kathrin Pallauf et al.   AGEING RESEARCH REVIEWS

Targeting Tumor Ubiquitin-Proteasome Pathway with Polyphenols for Chemosensitization

(2012) Min Shen et al.   Anti-Cancer Agents in Medicinal Chemistry

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

(2012) Jingyi Zhou et al.   Autophagy

Ferulic Acid Induces Mammalian Target of Rapamycin Inactivation in Cultured Mammalian Cells

(2012) Zehua Bian et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protective Effects of Ferulic Acid in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mouse Model of Alzheimer Disease

(2012) Ji-Jing Yan et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Development and evaluation of multifunctional agents for potential treatment of Alzheimer’s disease: Application to a pyrimidine-2,4-diamine template

(2012) Tarek Mohamed et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oleuropein, an Anti-oxidant Polyphenol Constituent of Olive Promotes α-Secretase Cleavage of the Amyloid Precursor Protein (AβPP)

(2012) Myrta Kostomoiri et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Phenolic, Polysaccharidic, and Lipidic Fractions of Mushrooms from Northeastern Portugal: Chemical Compounds with Antioxidant Properties

(2012) Sandrina A. Heleno et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Design and Synthesis of Potent, Orally Efficacious Hydroxyethylamine Derived β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors

(2012) Thomas A. Dineen et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

(2012) María Isabel Fernández-Bachiller et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: A randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg

(2012) Horst Herrschaft et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy

(2012) Robert Nisticò et al.   MOLECULAR NEUROBIOLOGY

Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy

(2012) Shang-Ming Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Selective inhibition of MMP-9 gene expression by mangiferin in PMA-stimulated human astroglioma cells: Involvement of PI3K/Akt and MAPK signaling pathways

(2012) Ji-Sun Jung et al.   PHARMACOLOGICAL RESEARCH

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Synthesis and characterization of ligational behavior of curcumin drug towards some transition metal ions: Chelation effect on their thermal stability and biological activity

(2012) Moamen S. Refat   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2–NFκB pathways

(2012) Joydeep Das et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Baicalein Inhibits Formation of α-Synuclein Oligomers within Living Cells and Prevents Aβ Peptide Fibrillation and Oligomerisation

(2011) Jia-Hong Lu et al.   CHEMBIOCHEM

Hydroxytyrosol reduces intracellular reactive oxygen species levels in vascular endothelial cells by upregulating catalase expression through the AMPK–FOXO3a pathway

(2011) Houda Zrelli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Effect of food on the pharmacokinetic profile of trans-resveratrol

(2011) M. Vaz-da-Silva et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Quercetin and rutin exhibit antiamyloidogenic and fibril-disaggregating effects in vitro and potent antioxidant activity in APPswe cells

(2011) Karim Jiménez-Aliaga et al.   LIFE SCIENCES

Modulation of Nrf2/ARE Pathway by Food Polyphenols: A Nutritional Neuroprotective Strategy for Cognitive and Neurodegenerative Disorders

(2011) Giovanni Scapagnini et al.   MOLECULAR NEUROBIOLOGY

Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK/p38 MAPK and p53 activity

(2011) Wei-Wei Li et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Luteolin Inhibits Apoptosis and Improves Cardiomyocyte Contractile Function through the PI3K/Akt Pathway in Simulated Ischemia/Reperfusion

(2011) Fang Fang et al.   PHARMACOLOGY

Efficacy and Tolerability of a Once Daily Formulation of Ginkgo biloba Extract EGb 761® in Alzheimer's Disease and Vascular Dementia: Results from a Randomised Controlled Trial

(2011) R. Ihl et al.   PHARMACOPSYCHIATRY

Regulation of SIRT1 in cellular functions: Role of polyphenols

(2010) Sangwoon Chung et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

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(2010) Joshua D Grill et al.   Expert Review of Neurotherapeutics

Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids

(2010) Dharmendra Kumar Maurya et al.   FOOD AND CHEMICAL TOXICOLOGY

Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression

(2010) Yong Pil Hwang et al.   FOOD AND CHEMICAL TOXICOLOGY

Lipofuscin inhibits the proteasome by binding to surface motifs

(2010) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

(2010) J. D. Brioni et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance

(2010) Laura Bravo   NUTRITION REVIEWS

Resveratrol Induces Growth Arrest and Apoptosis through Activation of FOXO Transcription Factors in Prostate Cancer Cells

(2010) Qinghe Chen et al.   PLoS One

Alzheimer's Disease: From Pathology to Therapeutic Approaches

(2009) Roland Jakob-Roetne et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and β-secretase

(2009) Yiping Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Progress in the Development of Nonpeptidomimetic BACE 1 Inhibitors for Alzheimers Disease

(2009) Wen-Hai Huang et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidants in Wild Mushrooms

(2009) Isabel Ferreira et al.   CURRENT MEDICINAL CHEMISTRY

Resveratrol and Neurodegenerative Diseases: Activation of SIRT1 as the Potential Pathway towards Neuroprotection

(2009) Merce Pallas et al.   CURRENT NEUROVASCULAR RESEARCH

Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1

(2009) Lin Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited

(2009) Allana M. Mancino et al.   INORGANIC CHEMISTRY

Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway

(2009) Chao Liu et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

(2009) Luis Almeida et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

Phenolic Compound Concentration and Antioxidant Activities of Edible and Medicinal Mushrooms from Korea

(2008) Min-Young Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron-binding and anti-Fenton properties of baicalein and baicalin

(2008) Carlos A. Perez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

(2008) Scott C. Mayer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Dietary activators of Sirt1

(2008) Joanne S. Allard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy inhibition enhances anthocyanin-induced apoptosis in hepatocellular carcinoma

(2008) L. Longo et al.   MOLECULAR CANCER THERAPEUTICS

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal

(2008) Domenico Praticò   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

(2008) A. Rajeswari et al.   INFLAMMOPHARMACOLOGY