Inhibition of amyloid oligomerization into different supramolecular architectures by small molecules: mechanistic insights and design rules

Scrutiny of the mechanism of small molecule inhibitor preventing conformational transition of amyloid-β42 monomer: insights from molecular dynamics simulations

(2017) Suniba Shuaib et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

(2017) Michele Perni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics

(2017) Ashim Paul et al.   Scientific Reports

Increase of Positive Net Charge and Conformational Rigidity Enhances the Efficacy of d-Enantiomeric Peptides Designed to Eliminate Cytotoxic Aβ Species

(2016) Tamar Ziehm et al.   ACS Chemical Neuroscience

Natural Tripeptide-Based Inhibitor of Multifaceted Amyloid β Toxicity

(2016) K. Rajasekhar et al.   ACS Chemical Neuroscience

Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer′s Disease

(2016) Federica Prati et al.   ChemMedChem

Molecular Simulations of Amyloid Structures, Toxicity, and Inhibition

(2016) Mingzhen Zhang et al.   ISRAEL JOURNAL OF CHEMISTRY

Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity

(2016) Moran Frenkel-Pinter et al.   JOURNAL OF ALZHEIMERS DISEASE

Hematoxylin Inhibits Amyloid β-Protein Fibrillation and Alleviates Amyloid-Induced Cytotoxicity

(2016) Yilong Tu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

QSAR, docking, and Molecular dynamic studies on the polyphenolic as inhibitors of β-amyloid aggregation

(2016) Najmeh Mahmoodabadi et al.   MEDICINAL CHEMISTRY RESEARCH

Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity

(2016) Moran Frenkel-Pinter et al.   Neurodegenerative Diseases

Design of LVFFARK and LVFFARK-Functionalized Nanoparticles for Inhibiting Amyloid β-Protein Fibrillation and Cytotoxicity

(2015) Neng Xiong et al.   ACS Applied Materials & Interfaces

Tabersonine Inhibits Amyloid Fibril Formation and Cytotoxicity of Aβ(1–42)

(2015) Tianhan Kai et al.   ACS Chemical Neuroscience

Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice

(2015) David I. Finkelstein et al.   ACS Chemical Neuroscience

Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide

(2015) Ashim Paul et al.   CHEMICAL COMMUNICATIONS

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Neurodegenerative diseases and therapeutic strategies using iron chelators

(2015) Roberta J. Ward et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Edaravone alleviates Alzheimer’s disease-type pathologies and cognitive deficits

(2015) Shu-Sheng Jiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity

(2015) Wen-Jie Du et al.   Scientific Reports

Reversal of Aggregation Using β-Breaker Dipeptide Containing Peptides: Application to Aβ(1–40) Self-Assembly and Its Inhibition

(2014) Krishna Chaitanya Nadimpally et al.   ACS Chemical Neuroscience

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained fromcyclo[-Lys-Leu-Val-Phe-Phe-]

(2014) Tadamasa Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Activity Relationships for a Series of Compounds that Inhibit Aggregation of the Alzheimer's Peptide, Aβ42

(2014) Angela F. McKoy et al.   Chemical Biology & Drug Design

Biological metals and metal-targeting compounds in major neurodegenerative diseases

(2014) Kevin J. Barnham et al.   CHEMICAL SOCIETY REVIEWS

Back Cover: Multifunctional 8-Hydroxyquinoline-Appended Cyclodextrins as New Inhibitors of Metal-Induced Protein Aggregation (Chem. Eur. J. 29/2014)

(2014) Valentina Oliveri et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structure–activity relationships of sugar-based peptidomimetics as modulators of amyloid β-peptide early oligomerization and fibrillization

(2014) Julia Kaffy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

8-Hydroxyquinoline Schiff-base compounds as antioxidants and modulators of copper-mediated Aβ peptide aggregation

(2014) Luiza M.F. Gomes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

General Amyloid Inhibitors? A Critical Examination of the Inhibition of IAPP Amyloid Formation by Inositol Stereoisomers

(2014) Hui Wang et al.   PLoS One

Feasibility of β-Sheet Breaker Peptide-H102 Treatment for Alzheimer's Disease Based on β-Amyloid Hypothesis

(2014) Lai-xiang Lin et al.   PLoS One

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

Effects of several quinones on insulin aggregation

(2014) Hao Gong et al.   Scientific Reports

Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells

(2013) Qiuming Wang et al.   ACS Chemical Neuroscience

Structure–Activity Relationship for (+)-Taxifolin Isolated from Silymarin as an Inhibitor of Amyloid β Aggregation

(2013) Mizuho SATO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Conformationally restricted short peptides inhibit human islet amyloid polypeptide (hIAPP) fibrillization

(2013) Aseem Mishra et al.   CHEMICAL COMMUNICATIONS

Inhibiting and Reversing Amyloid-β Peptide (1-40) Fibril Formation with Gramicidin S and Engineered Analogues

(2013) Jinghui Luo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design, Synthesis, and Evaluation of Multitarget-Directed Resveratrol Derivatives for the Treatment of Alzheimer’s Disease

(2013) Chuanjun Lu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Toward the Molecular Mechanism(s) by Which EGCG Treatment Remodels Mature Amyloid Fibrils

(2013) Fernando L. Palhano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry Reveals the Mechanism of Amyloid Formation of Aβ(25–35) and Its Modulation by Inhibitors at the Molecular Level: Epigallocatechin Gallate and Scyllo-inositol

(2013) Christian Bleiholder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A novel hybrid of 6-chlorotacrine and metal–amyloid-β modulator for inhibition of acetylcholinesterase and metal-induced amyloid-β aggregation

(2013) Akiko Kochi et al.   Chemical Science

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs

(2012) Valentina Oliveri et al.   DALTON TRANSACTIONS

Modulating metals as a therapeutic strategy for Alzheimer’s disease

(2012) Lin W Hung et al.   Future Medicinal Chemistry

Tannic Acid Is a Natural β-Secretase Inhibitor That Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice

(2012) Takashi Mori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation

(2012) Heiko Kroth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model

(2012) R. Scherzer-Attali et al.   NEUROBIOLOGY OF DISEASE

Structural Basis for Inhibiting β-Amyloid Oligomerization by a Non-coded β-Breaker-Substituted Endomorphin Analogue

(2011) Anat Frydman-Marom et al.   ACS Chemical Biology

The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide

(2011) Anat Frydman-Marom et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Disassembly of preformed amyloid beta fibrils by small organofluorine molecules

(2011) Abha Sood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Shedding Light on Alzheimer's β-Amyloid Aggregation with Chemical Tools

(2011) Aphrodite Kapurniotu   CHEMBIOCHEM

Natural polyphenols inhibit different steps of the process of transthyretin (TTR) amyloid fibril formation

(2011) Nelson Ferreira et al.   FEBS LETTERS

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

Structure−Activity Relationships in Peptide Modulators of β-Amyloid Protein Aggregation: Variation in α,α-Disubstitution Results in Altered Aggregate Size and Morphology

(2010) Cyrus K. Bett et al.   ACS Chemical Neuroscience

Dopamine quinones interact with α-synuclein to form unstructured adducts

(2010) Marco Bisaglia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clioquinol: Review of its Mechanisms of Action and Clinical Uses in Neurodegenerative Disorders

(2010) Silvio R. Bareggi et al.   CNS Neuroscience & Therapeutics

Small moleculeβ-amyloid inhibitors that stabilize protofibrillar structuresin vitroimprove cognition and pathology in a mouse model of Alzheimer’s disease

(2010) Cheryl A. Hawkes et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins

(2010) Jihoon Kim et al.   Prion

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of chirality of small molecule organofluorine inhibitors of amyloid self-assembly on inhibitor potency

(2009) Abha Sood et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protective effect of pyrroloquinoline quinone against Aβ-induced neurotoxicity in human neuroblastoma SH-SY5Y cells

(2009) Jun-Jing Zhang et al.   NEUROSCIENCE LETTERS

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

(2009) Ying Feng et al.   NEUROTOXICOLOGY

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility

(2009) Li Ling Lee et al.   PROTEIN SCIENCE

Amyloids: Not Only Pathological Agents but Also Ordered Nanomaterials

(2008) Izhack Cherny et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cognitive-Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies

(2008) Anat Frydman-Marom et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Influence of fluorinated and hydrogenated nanoparticles on the structure and fibrillogenesis of amyloid beta-peptide

(2008) Sandra Rocha et al.   BIOPHYSICAL CHEMISTRY

Green tea extracts interfere with the stress-protective activity of PrPCand the formation of PrPSc

(2008) Angelika S. Rambold et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Escaping amyloid fate

(2008) Blake E Roberts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Amyloid Fibrillization of Hen Egg-White Lysozymes by Rifampicin and p-Benzoquinone

(2007) Valerie H. Lieu et al.   BIOTECHNOLOGY PROGRESS