Extracellular Vesicles: A Possible Link between HIV and Alzheimer’s Disease-Like Pathology in HIV Subjects?

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

(2019) Matt Kaeberlein et al.   Science Translational Medicine

Does HIV infection contribute to increased beta-amyloid synthesis and plaque formation leading to neurodegeneration and Alzheimer’s disease?

(2019) Tamas Fulop et al.   JOURNAL OF NEUROVIROLOGY

Proteomic Profiling of Exosomes Derived from Plasma of HIV-Infected Alcohol Drinkers and Cigarette Smokers

(2019) Sunitha Kodidela et al.   Journal of Neuroimmune Pharmacology

Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies

(2019) Mohammad A. Rahman et al.   Journal of Neuroimmune Pharmacology

Associations of regional amyloid-β plaque and phospho-tau pathology with biological factors and neuropsychological functioning among HIV-infected adults

(2019) Virawudh Soontornniyomkij et al.   JOURNAL OF NEUROVIROLOGY

HIV and Alzheimer’s disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein

(2019) Alina Hategan et al.   JOURNAL OF NEUROVIROLOGY

A brief history of “Alzheimer disease”

(2019) David S. Knopman et al.   NEUROLOGY

Plasma exosomes exacerbate alcohol- and acetaminophen-induced toxicity via CYP2E1 pathway

(2019) Mohammad A. Rahman et al.   Scientific Reports

Profile of neuronal exosomes in HIV cognitive impairment exposes sex differences

(2019) Bing Sun et al.   AIDS

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

Mechanism of recipient cell-dependent differences in exosome uptake

(2018) Sayo Horibe et al.   BMC CANCER

Neprilysin in the Cerebrospinal Fluid and Serum of Patients Infected With HIV1-Subtypes C and B

(2018) Sérgio M. de Almeida et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exosomes as possible spread factor and potential biomarkers in Alzheimer's disease: current concepts

(2018) Ryszard Pluta et al.   Biomarkers in Medicine

Evidence that the Amyloid-β Protein Precursor Intracellular Domain, AICD, Derives From β-Secretase-Generated C-Terminal Fragment

(2018) Brice Flammang et al.   JOURNAL OF ALZHEIMERS DISEASE

Nrf2-Mediated System xc− Activation in Astroglial Cells Is Involved in HIV-1 Tat-Induced Neurotoxicity

(2018) Roberta Mastrantonio et al.   MOLECULAR NEUROBIOLOGY

Exosome Drug Delivery through the Blood–Brain Barrier: Experimental Approaches and Potential Applications

(2018) T. A. Druzhkova et al.   Neurochemical Journal

Cytokine profiling of exosomes derived from the plasma of HIV-infected alcohol drinkers and cigarette smokers

(2018) Sunitha Kodidela et al.   PLoS One

HIV Neuroinfection and Alzheimer’s Disease: Similarities and Potential Links?

(2018) Geoffrey Canet et al.   Frontiers in Cellular Neuroscience

From Inflammasome to Exosome—Does Extracellular Vesicle Secretion Constitute an Inflammasome-Dependent Immune Response?

(2018) Wojciech Cypryk et al.   Frontiers in Immunology

The role of exosomal transport of viral agents in persistent HIV pathogenesis

(2018) Benjamin J. Patters et al.   Retrovirology

Exosome: a novel mediator in drug resistance of cancer cells

(2018) He-da Zhang et al.   Epigenomics

The Ambiguous Roles of Extracellular Vesicles in HIV Replication and Pathogenesis

(2018) Marcos V. S. Dias et al.   Frontiers in Microbiology

Recent advancements in the use of exosomes as drug delivery systems

(2018) Edwin J. Bunggulawa et al.   JOURNAL OF NANOBIOTECHNOLOGY

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation

(2017) Ernest T. Chivero et al.   JOURNAL OF NEUROSCIENCE

The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration

(2017) Jerel A. Fields et al.   JOURNAL OF NEUROVIROLOGY

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease

(2017) Jun Yin et al.   MOLECULAR NEUROBIOLOGY

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Curcumin-primed and curcumin-loaded exosomes: potential neural therapy

(2017) Anuradha Kalani et al.   Neural Regeneration Research

Increased brain-predicted aging in treated HIV disease

(2017) James H. Cole et al.   NEUROLOGY

Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence

(2017) Mona Hersi et al.   NEUROTOXICOLOGY

HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway

(2017) Wenlin Jiang et al.   Oxidative Medicine and Cellular Longevity

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

(2017) Qingqing Chai et al.   Nature Communications

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication

(2017) Sanjana Haque et al.   Scientific Reports

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

(2017) Anush Arakelyan et al.   Scientific Reports

Plasma Exosomes Spread and Cluster Around β-Amyloid Plaques in an Animal Model of Alzheimer’s Disease

(2017) Tingting Zheng et al.   Frontiers in Aging Neuroscience

Differentiating HIV-Associated Neurocognitive Disorders From Alzheimer’s Disease: an Emerging Issue in Geriatric NeuroHIV

(2017) Benedetta Milanini et al.   Current HIV/AIDS Reports

Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

(2017) Sayad Kocahan et al.   Clinical Psychopharmacology and Neuroscience

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Caffeine as a Protective Factor in Dementia and Alzheimer's Disease

(2017) Marjo H. Eskelinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Life expectancy of HIV-positive people after starting combination antiretroviral therapy: a meta-analysis

(2016) S Teeraananchai et al.   HIV MEDICINE

Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury

(2016) Anuradha Kalani et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation

(2016) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein

(2016) Pejman Rahimian et al.   JOURNAL OF NEUROVIROLOGY

HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment

(2016) Deanna Saylor et al.   Nature Reviews Neurology

HIV-1 Tat Regulates Occludin and AβTransfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway

(2016) Yanlan Chen et al.   Oxidative Medicine and Cellular Longevity

Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications

(2016) Guoku Hu et al.   Cell Death & Disease

Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice

(2016) Vir B. Singh et al.   Scientific Reports

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Curcumin inhibits HIV-1 by promoting Tat protein degradation

(2016) Amjad Ali et al.   Scientific Reports

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Using exosomes, naturally-equipped nanocarriers, for drug delivery

(2015) Elena V. Batrakova et al.   JOURNAL OF CONTROLLED RELEASE

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Exosomes: Implications in HIV-1 Pathogenesis

(2015) Marisa Madison et al.   Viruses-Basel

HIV effects on age-associated neurocognitive dysfunction: premature cognitive aging or neurodegenerative disease?

(2015) Ronald A Cohen et al.   Alzheimers Research & Therapy

The cerebrospinal fluid biomarker profile in an HIV-infected subject with Alzheimer’s disease

(2015) Signar Mäkitalo et al.   AIDS Research and Therapy

The impact of HIV-1 on neurogenesis: implications for HAND

(2014) Darren Ferrell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A potential function for neuronal exosomes: Sequestering intracerebral amyloid-β peptide

(2014) Kohei Yuyama et al.   FEBS LETTERS

The metabolic response to excitotoxicity – lessons from single-cell imaging

(2014) Niamh M. C. Connolly et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice

(2014) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Exosomes as mediators of neuroinflammation

(2014) Archana Gupta et al.   Journal of Neuroinflammation

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity

(2013) Caterina Capone et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

(2013) Stacey S. Willard et al.   International Journal of Biological Sciences

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

(2013) Michelle C. Potter et al.   Journal of Neuroimmune Pharmacology

HIV-associated neurocognitive disorder

(2013) David B Clifford et al.   LANCET INFECTIOUS DISEASES

The effects of aging and Alzheimer's disease on cerebral cortical anatomy: Specificity and differential relationships with cognition

(2013) Akram Bakkour et al.   NEUROIMAGE

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein

(2013) Jiyoung Kim et al.   PLoS One

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The Neuropsychological Profile of Alzheimer Disease

(2013) S. Weintraub et al.   Cold Spring Harbor Perspectives in Medicine

Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load

(2012) Michael J. Peluso et al.   AIDS

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical and Biologic Characterization of Exosomes and Microvesicles as Facilitators of HIV-1 Infection in Macrophages

(2012) I. Kadiu et al.   JOURNAL OF IMMUNOLOGY

Effect of Aging and Human Immunodeficiency Virus Infection on Cognitive Abilities

(2012) Nicoletta Ciccarelli et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells

(2012) Ming Li et al.   PROTEOMICS

Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir

(2012) Adriano Ferrucci et al.   VIRUS RESEARCH

Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease

(2012) Valérie Vingtdeux et al.   Frontiers in Physiology

Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease Brain

(2011) Katherine J. Kopeikina et al.   AMERICAN JOURNAL OF PATHOLOGY

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

(2011) Seng Chuan Tang et al.   INTERNATIONAL JOURNAL OF CANCER

HIV-1 gp120-Induced Axonal Injury Detected by Accumulation of β-Amyloid Precursor Protein in Adult Rat Corpus Callosum

(2011) Jingdong Zhang et al.   Journal of Neuroimmune Pharmacology

Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

(2010) Ana Canestri et al.   CLINICAL INFECTIOUS DISEASES

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

(2010) Robert K. Heaton et al.   JOURNAL OF NEUROVIROLOGY

Neurodegeneration and the neurovascular unit

(2010) Berislav V Zlokovic   NATURE MEDICINE

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures

(2010) M.Y. Aksenov et al.   NEUROSCIENCE LETTERS

Leukocyte transmigration across the blood-brain barrier: perspectives on neuroAIDS

(2009) Toni Kay Roberts   Frontiers in Bioscience-Landmark

Mitochondria Influence Fas Expression in GP120-Induced Apoptosis of Neuronal Cells

(2009) Sunil Thomas et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

Acquired immunodeficiency syndrome and the blood-brain barrier

(2009) Nathan S Ivey et al.   JOURNAL OF NEUROVIROLOGY

Beta-Amyloid Deposition and the Aging Brain

(2009) Karen M. Rodrigue et al.   NEUROPSYCHOLOGY REVIEW

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

The Comorbidity of HIV-Associated Neurocognitive Disorders and Alzheimer’s Disease: A Foreseeable Medical Challenge in Post-HAART Era

(2008) Jiqing Xu et al.   Journal of Neuroimmune Pharmacology

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

(2007) Andrew J. Farrall et al.   NEUROBIOLOGY OF AGING