HIV and Alzheimer’s disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer’s disease

(2019) Lynn Pulliam et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 increases extracellular amyloid-beta levels through neprilysin regulation in primary cultures of human astrocytes

(2018) Marta Martínez-Bonet et al.   JOURNAL OF CELLULAR PHYSIOLOGY

High resolution crystal structure of substrate-free human neprilysin

(2018) Stephen Moss et al.   JOURNAL OF STRUCTURAL BIOLOGY

Blood-derived amyloid-β protein induces Alzheimer’s disease pathologies

(2017) X-L Bu et al.   MOLECULAR PSYCHIATRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Self-aggregation propensity of the Tat peptide revealed by UV-Vis, NMR and MD analyses

(2017) Sara Macchi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity

(2017) Alina Hategan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Testing the Neurovascular Hypothesis of Alzheimer's Disease: LRP-1 Antisense Reduces Blood-brain Barrier Clearance, Increases Brain Levels of Amyloid-β Protein, and Impairs Cognition

(2017) Laura B. Jaeger et al.   JOURNAL OF ALZHEIMERS DISEASE

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Caffeine Blocks HIV-1 Tat-Induced Amyloid Beta Production and Tau Phosphorylation

(2016) Mahmoud L. Soliman et al.   Journal of Neuroimmune Pharmacology

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The uptake of HIV Tat peptide proceeds via two pathways which differ from macropinocytosis

(2015) Nadav Ben-Dov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mechanisms of HIV-1 Tat Neurotoxicity via CDK5 Translocation and Hyper-Activation: Role in HIV-Associated Neurocognitive Disorders

(2015) Jerel Fields et al.   CURRENT HIV RESEARCH

HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase

(2015) Ferdous Kadri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-Tat Protein Forms Phosphoinositide-dependent Membrane Pores Implicated in Unconventional Protein Secretion

(2015) Marcel Zeitler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders

(2015) J. Fields et al.   JOURNAL OF NEUROSCIENCE

Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer’s mice

(2015) Song Li et al.   Scientific Reports

The impact of HIV-1 on neurogenesis: implications for HAND

(2014) Darren Ferrell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PPAR Agonist-Mediated Protection against HIV Tat-Induced Cerebrovascular Toxicity is Enhanced in MMP-9-Deficient Mice

(2014) Wen Huang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Comparison of Structure Determination Methods for Intrinsically Disordered Amyloid-β Peptides

(2014) K. Aurelia Ball et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Synaptodendritic injury with HIV-Tat protein: What is the therapeutic target?

(2013) Avindra Nath et al.   EXPERIMENTAL NEUROLOGY

Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production

(2013) Xuesong Chen et al.   NEUROBIOLOGY OF AGING

A Novel Retro-Inverso Peptide Inhibitor Reduces Amyloid Deposition, Oxidation and Inflammation and Stimulates Neurogenesis in the APPswe/PS1ΔE9 Mouse Model of Alzheimer’s Disease

(2013) Vadivel Parthsarathy et al.   PLoS One

HIV-1 Tat Interacts with and Regulates the Localization and Processing of Amyloid Precursor Protein

(2013) Jiyoung Kim et al.   PLoS One

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles and functions of HIV-1 Tat protein in the CNS: an overview

(2013) Asen Bagashev et al.   Virology Journal

Role of Endolysosomes in HIV-1 Tat-Induced Neurotoxicity

(2012) Liang Hui et al.   ASN Neuro

Amyloid beta accumulation in HIV-1-infected brain: The role of the blood brain barrier

(2012) Ibolya E. András et al.   IUBMB LIFE

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

HIV-1 Tat-induced cerebrovascular toxicity is enhanced in mice with amyloid deposits

(2011) Lei Chen et al.   NEUROBIOLOGY OF AGING

Effect of Surfaces on Amyloid Fibril Formation

(2011) Bradley Moores et al.   PLoS One

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

(2011) Brian Giunta et al.   Molecular Brain

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Structural conversion of neurotoxic amyloid-β1–42 oligomers to fibrils

(2010) Mahiuddin Ahmed et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HIV-1 protein-mediated amyloidogenesis in rat hippocampal cell cultures

(2010) M.Y. Aksenov et al.   NEUROSCIENCE LETTERS

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

Intrinsic Disorder and Function of the HIV-1 Tat Protein

(2010) Shaheen Shojania et al.   PROTEIN AND PEPTIDE LETTERS

Attenuated neurotoxicity of the transactivation-defective HIV-1 Tat protein in hippocampal cell cultures

(2009) Michael Y. Aksenov et al.   EXPERIMENTAL NEUROLOGY

Mechanism for HIV-1 Tat Insertion into the Endosome Membrane

(2009) Hocine Yezid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV Regulation of Amyloid Beta Production

(2009) Lynn Pulliam   Journal of Neuroimmune Pharmacology

Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients

(2009) Cristian L. Achim et al.   Journal of Neuroimmune Pharmacology

HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin

(2009) Ibolya E. András et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Role of Tat Protein in HIV Neuropathogenesis

(2009) Wenxue Li et al.   NEUROTOXICITY RESEARCH

HIV TAT Forms Pores in Membranes by Inducing Saddle-Splay Curvature: Potential Role of Bidentate Hydrogen Bonding

(2008) Abhijit Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Simvastatin Protects against Amyloid   and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells

(2008) I. E. Andras et al.   MOLECULAR PHARMACOLOGY