Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

Signaling Mechanism of HIV-1 gp120 and Virion-Induced IL-1  Release in Primary Human Macrophages

(2014) R. Cheung et al.   JOURNAL OF IMMUNOLOGY

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

(2012) Sylvia Fitting et al.   BIOLOGICAL PSYCHIATRY

Glutamate Carboxypeptidase II in Diagnosis and Treatment of Neurologic Disorders and Prostate Cancer

(2012) C. Barinka et al.   CURRENT MEDICINAL CHEMISTRY

Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis

(2012) L. B. Jaeger et al.   Disease Models & Mechanisms

Interferon-α Regulates Glutaminase 1 Promoter through STAT1 Phosphorylation: Relevance to HIV-1 Associated Neurocognitive Disorders

(2012) Lixia Zhao et al.   PLoS One

Rodent models for HIV-associated neurocognitive disorders

(2012) Santhi Gorantla et al.   TRENDS IN NEUROSCIENCES

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse

(2011) Amanda N. Carey et al.   BEHAVIOURAL BRAIN RESEARCH

Structure–activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators

(2011) Xuechao Xing et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat

(2011) AH Shin et al.   BRITISH JOURNAL OF PHARMACOLOGY

HIV-Associated Neurological Disorders

(2011) Ik L. Tan et al.   CNS DRUGS

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

(2011) Mary Ann Checkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Delineating HIV-Associated Neurocognitive Disorders Using Transgenic Models: The Neuropathogenic Actions of Vpr

(2011) Christopher Power et al.   Journal of Neuroimmune Pharmacology

Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

(2011) Y. Huang et al.   JOURNAL OF NEUROSCIENCE

The Ins and Outs of HIV-1 Tat

(2011) Solène Debaisieux et al.   TRAFFIC

Targeting Mitochondrial Glutaminase Activity Inhibits Oncogenic Transformation

(2010) Jian-Bin Wang et al.   CANCER CELL

MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival

(2010) Farshid Noorbakhsh et al.   FASEB JOURNAL

Memantine for AIDS Dementia Complex: Open-Label Report of ACTG 301

(2010) Yu Zhao et al.   HIV CLINICAL TRIALS

Ca2+-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X7receptor-mediated phosphoinositide 3-kinase signaling

(2010) Yu-Peng Liu et al.   JOURNAL OF NEUROCHEMISTRY

HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine–glutamate antiporter

(2010) Sunita Gupta et al.   NEUROSCIENCE LETTERS

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Corneal Stromal Bed Quality Obtained With Mechanical Microkeratome and Femtosecond Laser

(2009) Sathish Srinivasan et al.   CORNEA

Oral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats

(2009) Xiao-Qing Peng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

In vitroglutaminase regulation and mechanisms of glutamate generation in HIV-1-infected macrophage

(2009) Nathan Erdmann et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism

(2009) Zheng-Xiong Xi et al.   JOURNAL OF NEUROCHEMISTRY

GCP II inhibition rescues neurons from gp120IIIB-induced neurotoxicity

(2009) Ajit G Thomas et al.   JOURNAL OF NEUROVIROLOGY

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

(2009) Mayte Coiras et al.   NATURE REVIEWS MICROBIOLOGY

Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR

(2009) Anne-Cécile Fricker et al.   NEUROPHARMACOLOGY

Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

(2009) Y. Pang et al.   NEUROSCIENCE

Glutamate Carboxypeptidase Inhibition Reduces the Severity of Chemotherapy-Induced Peripheral Neurotoxicity in Rat

(2009) Valentina A. Carozzi et al.   NEUROTOXICITY RESEARCH

Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV-1 tat transgenic mice

(2008) Annadora J. Bruce-Keller et al.   GLIA

HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase

(2008) Changhai Tian et al.   JOURNAL OF NEUROCHEMISTRY

Further characterization of the spatial learning deficit in the human immunodeficiency virus-1 transgenic rat

(2008) Abigail L Lashomb et al.   JOURNAL OF NEUROVIROLOGY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

(2007) Marcus Kaul   Frontiers in Bioscience-Landmark