Extracellular Vesicles: Intercellular Mediators in Alcohol-Induced Pathologies

ACG Clinical Guideline: Alcoholic Liver Disease

(2018) Ashwani K Singal et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice

(2018) Samir M. Amer et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90

(2018) Banishree Saha et al.   HEPATOLOGY

An Aspartyl Cathepsin Targeted PET Agent: Application in an Alzheimer’s Disease Mouse Model

(2018) Jonatan A. Snir et al.   JOURNAL OF ALZHEIMERS DISEASE

Role of Exosomes in Human Retroviral Mediated Disorders

(2018) Monique Anderson et al.   Journal of Neuroimmune Pharmacology

Extracellular vesicles as potential biomarkers for alcohol- and drug-induced liver injury and their therapeutic applications

(2018) Young-Eun Cho et al.   PHARMACOLOGY & THERAPEUTICS

In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication

(2018) Mohammad A. Rahman et al.   TOXICOLOGY LETTERS

Brain Pyroglutamate Amyloid-β is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimer's Disease Therapeutic

(2018) Gregory Hook et al.   JOURNAL OF ALZHEIMERS DISEASE

Cytokine profiling of exosomes derived from the plasma of HIV-infected alcohol drinkers and cigarette smokers

(2018) Sunitha Kodidela et al.   PLoS One

Exogenous exosomes from mice with acetaminophen-induced liver injury promote toxicity in the recipient hepatocytes and mice

(2018) Young-Eun Cho et al.   Scientific Reports

The role of exosomal transport of viral agents in persistent HIV pathogenesis

(2018) Benjamin J. Patters et al.   Retrovirology

Receptor-Ligand Interaction Mediates Targeting of Endothelial Colony Forming Cell-derived Exosomes to the Kidney after Ischemic Injury

(2018) Jose L. Viñas et al.   Scientific Reports

A Comparison of Lysosomal Enzymes Expression Levels in Peripheral Blood of Mild- and Severe-Alzheimer’s Disease and MCI Patients: Implications for Regenerative Medicine Approaches

(2017) Francesco Morena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

(2017) Yiwen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrogen Peroxide Stimulates Exosomal Cathepsin B Regulation of the Receptor for Advanced Glycation End-Products (RAGE)

(2017) Charles A. Downs et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker

(2017) Alessandra Santangelo et al.   JOURNAL OF NEURO-ONCOLOGY

Extracellular vesicles in renal disease

(2017) Diana Karpman et al.   Nature Reviews Nephrology

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

(2017) Shengli Li et al.   NUCLEIC ACIDS RESEARCH

Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells

(2017) Narasimha M. Midde et al.   PLoS One

Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs

(2017) Tek N. Lamichhane et al.   Scientific Reports

Processing of miR17-92 Cluster in Hepatic Stellate Cells Promotes Hepatic Fibrogenesis During Alcohol-Induced Injury

(2016) Elizabeth Brandon-Warner et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Inhibition of miR-21 rescues liver regeneration after partial hepatectomy in ethanol-fed rats

(2016) Egle Juskeviciute et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Exosomes as new diagnostic tools in CNS diseases

(2016) Katja M. Kanninen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Infection and Alcoholic Liver Disease

(2016) Christine Chan et al.   Clinics in Liver Disease

Cathepsin D as a therapeutic target in Alzheimer’s disease

(2016) Fabio Di Domenico et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

HIV-1 Tat Promotes Lysosomal Exocytosis in Astrocytes and Contributes to Astrocyte-mediated Tat Neurotoxicity

(2016) Yan Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress in retinal pigment epithelium cells increases exosome secretion and promotes angiogenesis in endothelial cells

(2016) Sandra Atienzar-Aroca et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Alcohol stimulates macrophage activation through caspase-dependent hepatocyte derived release of CD40L containing extracellular vesicles

(2016) Vikas K. Verma et al.   JOURNAL OF HEPATOLOGY

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

(2016) Christine M Embury et al.   Journal of Neuroimmune Pharmacology

Oxidative Stress during HIV Infection: Mechanisms and Consequences

(2016) Alexander V. Ivanov et al.   Oxidative Medicine and Cellular Longevity

Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method

(2016) Narasimha M. Midde et al.   PLoS One

Association between alcohol and Alzheimer's disease

(2016) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes

(2016) Hiroyuki Nojima et al.   PLoS One

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages

(2015) Banishree Saha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Do Circulating Tumor Cells, Exosomes, and Circulating Tumor Nucleic Acids Have Clinical Utility?

(2015) Bert Gold et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis

(2015) Fatemeh Momen-Heravi et al.   Journal of Translational Medicine

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

The role of exosomes in tumor progression and metastasis (Review)

(2015) WIKTORIA M. SUCHORSKA et al.   ONCOLOGY REPORTS

Exosomes: Implications in HIV-1 Pathogenesis

(2015) Marisa Madison et al.   Viruses-Basel

Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

(2015) Rui Shi et al.   Oncotarget

MiR-21 in Extracellular Vesicles Leads to Neurotoxicity via TLR7 Signaling in SIV Neurological Disease

(2015) Sowmya V. Yelamanchili et al.   PLoS Pathogens

Enhanced oxidative stress by alcohol use in HIV+ patients: possible involvement of cytochrome P450 2E1 and antioxidant enzymes

(2015) Anusha Ande et al.   AIDS Research and Therapy

Diagnostic and Prognostic Potential of Extracellular Vesicles in Peripheral Blood

(2014) Anne Louise Schacht Revenfeld et al.   CLINICAL THERAPEUTICS

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

Exosomal Proteins in the Aqueous Humor as Novel Biomarkers in Patients with Neovascular Age-related Macular Degeneration

(2014) Gum-Yong Kang et al.   JOURNAL OF PROTEOME RESEARCH

miR-21 improves the neurological outcome after traumatic brain injury in rats

(2014) Xin-Tong Ge et al.   Scientific Reports

Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes

(2014) Alyssa Charrier et al.   Journal of Cell Communication and Signaling

HIV-1 and Alcohol: Interactions in the Central Nervous System

(2013) Peter S. Silverstein et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Cardiac myocyte exosomes: stability, HSP60, and proteomics

(2013) Z. A. Malik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alcohol and toxicity

(2013) Ivan Rusyn et al.   JOURNAL OF HEPATOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Expression of 19 microRNAs in glioblastoma and comparison with other brain neoplasia of grades I-III

(2013) Michela Visani et al.   Molecular Oncology

Chronic ethanol feeding enhances miR-21 induction during liver regeneration while inhibiting proliferation in rats

(2012) Rachael P. Dippold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammation in Alcoholic Liver Disease

(2012) H. Joe Wang et al.   Annual Review of Nutrition

Alcohol Metabolism

(2012) Arthur I. Cederbaum   Clinics in Liver Disease

Alcohol consumption effect on antiretroviral therapy and HIV-1 pathogenesis: role of cytochrome P450 isozymes

(2012) Santosh Kumar et al.   Expert Opinion on Drug Metabolism & Toxicology

Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases

(2012) Shashi Bala et al.   HEPATOLOGY

Role of Cathepsin D in U18666A-induced Neuronal Cell Death

(2012) Asha Amritraj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42-Dependent Activation of NADPH Oxidase Is Involved in Ethanol-Induced Neuronal Oxidative Stress

(2012) Xin Wang et al.   PLoS One

Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes

(2012) Deyi Xiao et al.   PLoS One

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MicroRNAs: Master Regulators of Ethanol Abuse and Toxicity?

(2010) Rajesh C. Miranda et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce β-amyloid related to Alzheimer's disease

(2010) Vivian Hook et al.   BIOLOGICAL CHEMISTRY

Connective tissue growth factor production by activated pancreatic stellate cells in mouse alcoholic chronic pancreatitis

(2010) Alyssa L Charrier et al.   LABORATORY INVESTIGATION

Tau Phosphorylation and Cleavage in Ethanol-Induced Neurodegeneration in the Developing Mouse Brain

(2010) Mariko Saito et al.   NEUROCHEMICAL RESEARCH

The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element

(2010) Karine Gendron et al.   NUCLEIC ACIDS RESEARCH

Acetaldehyde Adducts in Alcoholic Liver Disease

(2010) Mashiko Setshedi et al.   Oxidative Medicine and Cellular Longevity

Working and Episodic Memory in HIV Infection, Alcoholism, and Their Comorbidity: Baseline and 1-Year Follow-Up Examinations

(2009) Rosemary Fama et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Ethanol enhances tau accumulation in neuroblastoma cells that inducibly express tau

(2008) Tania F. Gendron et al.   NEUROSCIENCE LETTERS

The function of the NADPH oxidase of phagocytes and its relationship to other NOXs in plants, invertebrates, and mammals

(2007) Anthony W. Segal   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY